Barry L Jacobs

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. ncbi request reprint Adult brain neurogenesis and psychiatry: a novel theory of depression
    B L Jacobs
    Program in Neuroscience, Princeton University, Princeton, NJ 08544 1010, USA
    Mol Psychiatry 5:262-9. 2000
  2. ncbi request reprint Adult brain neurogenesis and depression
    Barry L Jacobs
    Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Brain Behav Immun 16:602-9. 2002
  3. ncbi request reprint Activity of medullary serotonergic neurons in freely moving animals
    Barry L Jacobs
    Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Brain Res Brain Res Rev 40:45-52. 2002
  4. ncbi request reprint "Fatigue" of medullary but not mesencephalic raphe serotonergic neurons during locomotion in cats
    Casimir A Fornal
    Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Brain Res 1072:55-61. 2006
  5. ncbi request reprint Circadian variation in mouse hippocampal cell proliferation
    Linda J Kochman
    Program in Neuroscience, Princeton University, Princeton, NJ 08540 1010, USA
    Neurosci Lett 406:256-9. 2006
  6. doi request reprint Effects of the hypnotic drug zolpidem on cell proliferation and survival in the dentate gyrus of young and old rats
    Luiz F Takase
    Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Brain Res 1259:26-31. 2009
  7. pmc Suppression of hippocampal cell proliferation by short-term stimulant drug administration in adult rats
    Linda J Kochman
    Program in Neuroscience, Princeton University, Princeton, NJ 08544, USA
    Eur J Neurosci 29:2157-65. 2009
  8. ncbi request reprint Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism
    Jason J Radley
    Program in Neuroscience, Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Brain Res 966:1-12. 2003
  9. pmc Delayed suppression of hippocampal cell proliferation in rats following inescapable shocks
    Casimir A Fornal
    Program in Neuroscience, Princeton University, Princeton, NJ 08544, USA
    Brain Res 1130:48-53. 2007
  10. ncbi request reprint Insulin-induced hypoglycemia decreases single-unit activity of serotonergic medullary raphe neurons in freely moving cats: relationship to sympathetic and motor output
    Francisco J Martin-Cora
    Program in Neuroscience, Princeton University, Princeton, New Jersey 08544, USA
    Eur J Neurosci 16:722-34. 2002

Research Grants

  1. NEURAL SUBSTRATES OF AROUSAL AND EMOTION
    Barry Jacobs; Fiscal Year: 2005
  2. Marijuana & Cytokine Actions on Rat Brain Mitogenesis
    Barry Jacobs; Fiscal Year: 2004
  3. NEURAL SUBSTRATES OF AROUSAL AND EMOTION
    Barry Jacobs; Fiscal Year: 1990
  4. NEURAL SUBSTRATES OF AROUSAL AND EMOTION
    Barry Jacobs; Fiscal Year: 1991
  5. NEURAL SUBSTRATES OF AROUSAL AND EMOTION
    Barry Jacobs; Fiscal Year: 1980

Detail Information

Publications18

  1. ncbi request reprint Adult brain neurogenesis and psychiatry: a novel theory of depression
    B L Jacobs
    Program in Neuroscience, Princeton University, Princeton, NJ 08544 1010, USA
    Mol Psychiatry 5:262-9. 2000
    ..Thus, we hypothesize that the waning and waxing of neurogenesis in the hippocampal formation are important causal factors, respectively, in the precipitation of, and recovery from, episodes of clinical depression...
  2. ncbi request reprint Adult brain neurogenesis and depression
    Barry L Jacobs
    Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Brain Behav Immun 16:602-9. 2002
    ..The possible interaction of immune system factors, especially the proinflammatory cytokines, with adult brain neurogenesis is discussed...
  3. ncbi request reprint Activity of medullary serotonergic neurons in freely moving animals
    Barry L Jacobs
    Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Brain Res Brain Res Rev 40:45-52. 2002
    ..We hypothesize that the primary functions of this motor-related activity are to facilitate motor output, suppress processing of some forms of afferent activity, and to coordinate autonomic functioning with the current motor demand...
  4. ncbi request reprint "Fatigue" of medullary but not mesencephalic raphe serotonergic neurons during locomotion in cats
    Casimir A Fornal
    Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Brain Res 1072:55-61. 2006
    ..Full recovery of single unit activity to a level approximating the baseline discharge rate required 30-45 min. Possible mechanisms underlying these changes are discussed as is the role of serotonin and fatigue in human pathology...
  5. ncbi request reprint Circadian variation in mouse hippocampal cell proliferation
    Linda J Kochman
    Program in Neuroscience, Princeton University, Princeton, NJ 08540 1010, USA
    Neurosci Lett 406:256-9. 2006
    ..Since it is generally believed that proliferating cells in the hilus and GCL/SGZ give rise primarily to glia and neurons, respectively, these data suggest a possible circadian influence on gliogenesis, rather than neurogenesis...
  6. doi request reprint Effects of the hypnotic drug zolpidem on cell proliferation and survival in the dentate gyrus of young and old rats
    Luiz F Takase
    Program in Neuroscience, Green Hall, Princeton University, Princeton, NJ 08544, USA
    Brain Res 1259:26-31. 2009
    ..To the extent that zolpidem improves sleep, these data suggest little or no benefit of hypnotic drug treatment on neurogenesis parameters in young or old rats...
  7. pmc Suppression of hippocampal cell proliferation by short-term stimulant drug administration in adult rats
    Linda J Kochman
    Program in Neuroscience, Princeton University, Princeton, NJ 08544, USA
    Eur J Neurosci 29:2157-65. 2009
    ....
  8. ncbi request reprint Pilocarpine-induced status epilepticus increases cell proliferation in the dentate gyrus of adult rats via a 5-HT1A receptor-dependent mechanism
    Jason J Radley
    Program in Neuroscience, Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Brain Res 966:1-12. 2003
    ....
  9. pmc Delayed suppression of hippocampal cell proliferation in rats following inescapable shocks
    Casimir A Fornal
    Program in Neuroscience, Princeton University, Princeton, NJ 08544, USA
    Brain Res 1130:48-53. 2007
    ..These data raise questions about the general nature of the relationship between CORT and CP. They also suggest that, under some conditions, changes in hippocampal CP may emerge only after an "incubation period"...
  10. ncbi request reprint Insulin-induced hypoglycemia decreases single-unit activity of serotonergic medullary raphe neurons in freely moving cats: relationship to sympathetic and motor output
    Francisco J Martin-Cora
    Program in Neuroscience, Princeton University, Princeton, New Jersey 08544, USA
    Eur J Neurosci 16:722-34. 2002
    ....
  11. ncbi request reprint Despite strong behavioral disruption, Delta9-tetrahydrocannabinol does not affect cell proliferation in the adult mouse dentate gyrus
    Linda J Kochman
    Program in Neuroscience, Department of Psychology, Princeton University, Green Hall, Washington Road, Princeton, NJ 08540 1010, USA
    Brain Res 1113:86-93. 2006
    ..These findings provide no evidence for an effect of THC on hippocampal cell proliferation, even at doses producing gross behavioral intoxication. Whether marijuana or THC affects neurogenesis remains to be explored...
  12. ncbi request reprint 5-HT1A receptor antagonist administration decreases cell proliferation in the dentate gyrus
    Jason J Radley
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Brain Res 955:264-7. 2002
    ..This suggests that 5-HT(1A) receptor activity is important during naturally occurring cell proliferation in the dentate gyrus, and perhaps neurogenesis, and is one of the many factors involved in its regulation...
  13. ncbi request reprint Repeated brief social defeat episodes in mice: effects on cell proliferation in the dentate gyrus
    Jasmine J Yap
    Department of Psychology, Tufts University, 530 Boston Avenue, Bacon Hall, Medford, MA 02155, USA
    Behav Brain Res 172:344-50. 2006
    ....
  14. ncbi request reprint Single-unit responses of serotonergic medullary raphe neurons to cardiovascular challenges in freely moving cats
    Francisco J Martin-Cora
    Department of Physiology, School of Medicine, USC, Santiago de Compostela, Galicia 15782, Spain
    Eur J Neurosci 22:3195-204. 2005
    ..Taken within the context of our previous work, the present data suggest that medullary serotonergic neurons may modulate autonomic outflow, but only in relation to their primary role in motor control...
  15. ncbi request reprint Effect of number of tailshocks on learned helplessness and activation of serotonergic and noradrenergic neurons in the rat
    Luiz F Takase
    Departmento de Anatomia, Instituto de Ciências Biomédicas Universidade de São Paulo, Sao Paulo SP, Brasil
    Behav Brain Res 162:299-306. 2005
    ..The relevance of these results for elucidating the neural bases of psychopathology is discussed...
  16. doi request reprint The effect of prolonged anesthesia with isoflurane, propofol, dexmedetomidine, or ketamine on neural cell proliferation in the adult rat
    Avery Tung
    Department of Anesthesia and Critical Care, University of Chicago, Chicago, Illinois, USA
    Anesth Analg 106:1772-7. 2008
    ..To test this hypothesis, we investigated the effects of prolonged anesthesia with four different anesthetics on hippocampal cell proliferation in young and older rats...
  17. doi request reprint Age-dependent decline in hippocampal neurogenesis is not altered by chronic treatment with fluoxetine
    Daniel S Cowen
    Department of Psychiatry, University of Medicine and Dentistry of New Jersey Robert Wood Johnson Medical School, New Brunswick, NJ 08901, USA
    Brain Res 1228:14-9. 2008
    ..In addition to finding no age-dependent effects, our data question the general reproducibility of previously reported fluoxetine effects in animals...
  18. ncbi request reprint Inescapable shock activates serotonergic neurons in all raphe nuclei of rat
    Luiz F Takase
    Departmento de Anatomia, Instituto de Ciencias Biomedicas, Universidade de Sao Paulo, Sao Paulo SP, Brazil
    Behav Brain Res 153:233-9. 2004
    ..This stimulus exerted a consistent and strong activation of the entire midline brain stem system of serotonergic neurons. The implications of these findings for animal models of human psychopathology are discussed...

Research Grants20

  1. NEURAL SUBSTRATES OF AROUSAL AND EMOTION
    Barry Jacobs; Fiscal Year: 2005
    ....
  2. Marijuana & Cytokine Actions on Rat Brain Mitogenesis
    Barry Jacobs; Fiscal Year: 2004
    ..It is further hypothesized that the actions of the two compounds will be at least additive in suppressing DG mitogenesis. ..
  3. NEURAL SUBSTRATES OF AROUSAL AND EMOTION
    Barry Jacobs; Fiscal Year: 1990
    ..I.M.H. because of the involvement of brain NE and 5HT neurons in arousal and emotionality, and more generally, because of the role of stress in the etiology of various forms of psychopathology...
  4. NEURAL SUBSTRATES OF AROUSAL AND EMOTION
    Barry Jacobs; Fiscal Year: 1991
    ....
  5. NEURAL SUBSTRATES OF AROUSAL AND EMOTION
    Barry Jacobs; Fiscal Year: 1980
    ..The present research program seeks to clarify the functional role of CNS serotonin through animal experiments which analyze the basic component of the system, serotonin-containing neurons of the raphe nuclei, in freely moving cats. ..