David Gresham

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. ncbi request reprint Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Science 311:1932-6. 2006
  2. doi request reprint Comparing whole genomes using DNA microarrays
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Department of Molecular Biology, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Genet 9:291-302. 2008
  3. pmc Rise of the machines
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 4:e1000134. 2008
  4. pmc Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains
    Joseph Schacherer
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 2:e322. 2007
  5. pmc Dissection of genetically complex traits with extremely large pools of yeast segregants
    Ian M Ehrenreich
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 464:1039-42. 2010
  6. pmc Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes
    David Gresham
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 107:1482-7. 2010
  7. pmc The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    PLoS Genet 4:e1000303. 2008
  8. pmc Predicting cellular growth from gene expression signatures
    Edoardo M Airoldi
    Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, United States of America
    PLoS Comput Biol 5:e1000257. 2009
  9. pmc Global mapping of transposon location
    Abram Gabriel
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS Genet 2:e212. 2006
  10. pmc Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast
    Matthew J Brauer
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 19:352-67. 2008

Collaborators

Detail Information

Publications13

  1. ncbi request reprint Genome-wide detection of polymorphisms at nucleotide resolution with a single DNA microarray
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Science 311:1932-6. 2006
    ..We applied this approach to elucidate the genetic basis of phenotypic variants and to identify the small number of single-base pair changes accumulated during experimental evolution of yeast...
  2. doi request reprint Comparing whole genomes using DNA microarrays
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Department of Molecular Biology, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Genet 9:291-302. 2008
    ....
  3. pmc Rise of the machines
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 4:e1000134. 2008
  4. pmc Genome-wide analysis of nucleotide-level variation in commonly used Saccharomyces cerevisiae strains
    Joseph Schacherer
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 2:e322. 2007
    ..These data and new visualization tools are accessible online in a new resource: the Yeast SNPs Browser (YSB; http://gbrowse.princeton.edu/cgi-bin/gbrowse/yeast_strains_snps) that is available to all researchers...
  5. pmc Dissection of genetically complex traits with extremely large pools of yeast segregants
    Ian M Ehrenreich
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 464:1039-42. 2010
    ..Our method should have broad applications in yeast and can be extended to other organisms...
  6. pmc Optimized detection of sequence variation in heterozygous genomes using DNA microarrays with isothermal-melting probes
    David Gresham
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 107:1482-7. 2010
    ..Moreover, designing microarray probes with optimized sensitivity to mismatches should increase the accuracy of standard microarray applications such as copy-number variation detection and gene expression analysis...
  7. pmc The repertoire and dynamics of evolutionary adaptations to controlled nutrient-limited environments in yeast
    David Gresham
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ, USA
    PLoS Genet 4:e1000303. 2008
    ..Thus, in addition to answering basic mechanistic questions about evolutionary mechanisms, our work suggests that experimental evolution can also shed light on the function and regulation of individual metabolic pathways...
  8. pmc Predicting cellular growth from gene expression signatures
    Edoardo M Airoldi
    Lewis Sigler Institute for Integrative Genomics, Carl Icahn Laboratory, Princeton University, Princeton, New Jersey, United States of America
    PLoS Comput Biol 5:e1000257. 2009
    ..Data and tools enabling others to apply our methods are available at http://function.princeton.edu/growthrate...
  9. pmc Global mapping of transposon location
    Abram Gabriel
    Department of Molecular Biology and Biochemistry, Rutgers University, Piscataway, New Jersey, United States of America
    PLoS Genet 2:e212. 2006
    ..This unique whole genome view of transposon location will facilitate our exploration of transposon dynamics, as well as defining bases for individual differences and adaptive potential...
  10. pmc Coordination of growth rate, cell cycle, stress response, and metabolic activity in yeast
    Matthew J Brauer
    Lewis Sigler Institute for Integrative Genomics and Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Biol Cell 19:352-67. 2008
    ..This concept is useful in interpreting the system-level connections among growth rate, metabolism, stress, and the cell cycle...
  11. pmc Accumulation of recessive lethal mutations in Saccharomyces cerevisiae mlh1 mismatch repair mutants is not associated with gross chromosomal rearrangements
    Julie Akiko Heck
    Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York 14853 2703, USA
    Genetics 174:519-23. 2006
    ....
  12. pmc Mutation history of the roma/gypsies
    Bharti Morar
    Laboratory of Molecular Genetics, Western Australian Institute for Medical Research and UWA Centre for Medical Research, University of Western Australia, Perth, Australia
    Am J Hum Genet 75:596-609. 2004
    ....
  13. pmc The effective mutation rate at Y chromosome short tandem repeats, with application to human population-divergence time
    Lev A Zhivotovsky
    N I Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, Russia
    Am J Hum Genet 74:50-61. 2004
    ..This value is used to estimate the times of the African Bantu expansion, the divergence of Polynesian populations (the Maoris, Cook Islanders, and Samoans), and the origin of Gypsy populations from Bulgaria...