Thomas Gregor

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Diffusion and scaling during early embryonic pattern formation
    Thomas Gregor
    Howard Hughes Medical Institute, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 102:18403-7. 2005
  2. pmc Probing the limits to positional information
    Thomas Gregor
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Cell 130:153-64. 2007
  3. pmc Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryos
    Thomas Gregor
    Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Dev Biol 316:350-8. 2008
  4. pmc The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA
    Shawn C Little
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Biol 9:e1000596. 2011
  5. pmc Morphogenesis at criticality
    Dmitry Krotov
    Joseph Henry Laboratories of Physics, Lewis Sigler Institute for Integrative Genomics, and Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544
    Proc Natl Acad Sci U S A 111:3683-8. 2014
  6. pmc Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network
    Feng Liu
    Joseph Henry Laboratories of Physics and the Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 110:6724-9. 2013
  7. pmc Stability and nuclear dynamics of the bicoid morphogen gradient
    Thomas Gregor
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Cell 130:141-52. 2007
  8. pmc Precise developmental gene expression arises from globally stochastic transcriptional activity
    Shawn C Little
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Cell 154:789-800. 2013
  9. pmc Positional information, in bits
    Julien O Dubuis
    Joseph Henry Laboratories of Physics, Lewis Sigler Institute for Integrative Genomics, and Department of Molecular Biology, Princeton University, Princeton, NJ 08544
    Proc Natl Acad Sci U S A 110:16301-8. 2013
  10. pmc Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning
    Hernan G Garcia
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 23:2140-5. 2013

Collaborators

Detail Information

Publications15

  1. pmc Diffusion and scaling during early embryonic pattern formation
    Thomas Gregor
    Howard Hughes Medical Institute, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 102:18403-7. 2005
    ..Our results, together with constraints imposed by the time scales of development, suggest that the mechanism for scaling is a species-specific adaptation of the Bcd lifetime...
  2. pmc Probing the limits to positional information
    Thomas Gregor
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Cell 130:153-64. 2007
    ....
  3. pmc Shape and function of the Bicoid morphogen gradient in dipteran species with different sized embryos
    Thomas Gregor
    Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Dev Biol 316:350-8. 2008
    ..However, a shallow gradient was observed using eGFP-NLS, suggesting nuclear localization may be necessary but not sufficient for gradient formation...
  4. pmc The formation of the Bicoid morphogen gradient requires protein movement from anteriorly localized mRNA
    Shawn C Little
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Biol 9:e1000596. 2011
    ..We conclude that the spatial distribution of bicoid mRNA contributes to, but cannot account for, protein gradient formation, and therefore that protein movement, either active or passive, is required for gradient formation...
  5. pmc Morphogenesis at criticality
    Dmitry Krotov
    Joseph Henry Laboratories of Physics, Lewis Sigler Institute for Integrative Genomics, and Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544
    Proc Natl Acad Sci U S A 111:3683-8. 2014
    ..Although there might be other explanations for these individual phenomena, the confluence of evidence suggests that this genetic network is tuned to criticality. ..
  6. pmc Dynamic interpretation of maternal inputs by the Drosophila segmentation gene network
    Feng Liu
    Joseph Henry Laboratories of Physics and the Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 110:6724-9. 2013
    ....
  7. pmc Stability and nuclear dynamics of the bicoid morphogen gradient
    Thomas Gregor
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Cell 130:141-52. 2007
    ..A new model is presented emphasizing the possible role of nuclear dynamics in shaping and scaling the gradient...
  8. pmc Precise developmental gene expression arises from globally stochastic transcriptional activity
    Shawn C Little
    Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Cell 154:789-800. 2013
    ..The findings shed light on how the apparent paradox between stochastic transcription and developmental precision is resolved...
  9. pmc Positional information, in bits
    Julien O Dubuis
    Joseph Henry Laboratories of Physics, Lewis Sigler Institute for Integrative Genomics, and Department of Molecular Biology, Princeton University, Princeton, NJ 08544
    Proc Natl Acad Sci U S A 110:16301-8. 2013
    ..We argue that this constancy is a signature of optimality in the transmission of information from primary morphogen inputs to the output of the gap gene network...
  10. pmc Quantitative imaging of transcription in living Drosophila embryos links polymerase activity to patterning
    Hernan G Garcia
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 23:2140-5. 2013
    ..Thus, developmental patterns are not just the consequence of reproducible transcriptional dynamics in individual nuclei, but are the result of averaging expression over space and time...
  11. pmc Accurate measurements of dynamics and reproducibility in small genetic networks
    Julien O Dubuis
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 9:639. 2013
    ....
  12. pmc The role of input noise in transcriptional regulation
    Gasper Tkacik
    Joseph Henry Laboratories of Physics, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 3:e2774. 2008
    ....
  13. pmc Maternal origins of developmental reproducibility
    Mariela D Petkova
    Joseph Henry Laboratories of Physics, Princeton University, Princeton, NJ 08544, USA
    Curr Biol 24:1283-8. 2014
    ..Our results indicate that the reproducibility of the morphological structures of embryos originates during oogenesis, which is when the expression of maternally provided patterning factors is precisely controlled. ..
  14. ncbi request reprint Fly wing vein patterns have spatial reproducibility of a single cell
    Laurent Abouchar
    Joseph Henry Laboratories of Physics, and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    J R Soc Interface 11:20140443. 2014
    ..Could development be operating at the physical limit of what a biological system can achieve? ..
  15. pmc Sorting sloppy Sonic
    Shawn C Little
    Department of Molecular Biology and Howard Hughes Medical Institute, Princeton University, Princeton, NJ 08544, USA
    Cell 153:509-10. 2013
    ..Xiong et al. now provide evidence for an alternate strategy-cells of the zebrafish neural tube actively sort to their correct positions following disordered specification by Sonic hedgehog...