E Gould

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. ncbi request reprint Early NMDA receptor blockade impairs defensive behavior and increases cell proliferation in the dentate gyrus of developing rats
    E Gould
    Laboratory of Neuroendocrinology, Rockefeller University
    Behav Neurosci 111:49-56. 1997
  2. ncbi request reprint Is there a link between adult neurogenesis and learning?
    Benedetta Leuner
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Hippocampus 16:216-24. 2006
  3. ncbi request reprint Neurogenesis in adult mammals: some progress and problems
    Elizabeth Gould
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    J Neurosci 22:619-23. 2002
  4. ncbi request reprint How widespread is adult neurogenesis in mammals?
    Elizabeth Gould
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Neurosci 8:481-8. 2007
  5. ncbi request reprint Neurogenesis in the neocortex of adult primates
    E Gould
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Science 286:548-52. 1999
  6. pmc Hippocampal neurogenesis in adult Old World primates
    E Gould
    Department of Psychology, Princeton University, Princeton NJ 08544, USA
    Proc Natl Acad Sci U S A 96:5263-7. 1999
  7. pmc Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
    E Gould
    Department of Psychology, Princeton University, Green Hall, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 95:3168-71. 1998
  8. ncbi request reprint Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism
    E Gould
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Brain Res Dev Brain Res 103:91-3. 1997
  9. ncbi request reprint Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development
    E Gould
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Brain Res Dev Brain Res 101:265-8. 1997
  10. pmc Adult-generated hippocampal and neocortical neurons in macaques have a transient existence
    E Gould
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 98:10910-7. 2001

Research Grants

  1. ESTROGEN, HIPPOCAMPAL NEUROGENESIS AND LEARNING
    Elizabeth Gould; Fiscal Year: 2001
  2. Hormones, Experience and Hippocampal Neurogenesis
    Elizabeth Gould; Fiscal Year: 2009

Detail Information

Publications38

  1. ncbi request reprint Early NMDA receptor blockade impairs defensive behavior and increases cell proliferation in the dentate gyrus of developing rats
    E Gould
    Laboratory of Neuroendocrinology, Rockefeller University
    Behav Neurosci 111:49-56. 1997
    ....
  2. ncbi request reprint Is there a link between adult neurogenesis and learning?
    Benedetta Leuner
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Hippocampus 16:216-24. 2006
    ..This review discusses both sides of this issue, considering the effects of learning on the production of new neurons in the dentate gyrus and the question of whether newly born cells participate in learning and memory...
  3. ncbi request reprint Neurogenesis in adult mammals: some progress and problems
    Elizabeth Gould
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    J Neurosci 22:619-23. 2002
  4. ncbi request reprint How widespread is adult neurogenesis in mammals?
    Elizabeth Gould
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Rev Neurosci 8:481-8. 2007
    ..The discrepancies may be due to variations in the sensitivity of the methods used to detect new neurons...
  5. ncbi request reprint Neurogenesis in the neocortex of adult primates
    E Gould
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Science 286:548-52. 1999
    ..These new neurons, which are continually added in adulthood, may play a role in the functions of association neocortex...
  6. pmc Hippocampal neurogenesis in adult Old World primates
    E Gould
    Department of Psychology, Princeton University, Princeton NJ 08544, USA
    Proc Natl Acad Sci U S A 96:5263-7. 1999
    ..These results indicate that the adult brains of Old World monkeys produce new hippocampal neurons. Adult macaque monkeys may provide a useful primate model for studying the functional significance of adult neurogenesis...
  7. pmc Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stress
    E Gould
    Department of Psychology, Princeton University, Green Hall, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 95:3168-71. 1998
    ..Our results suggest that neurons are produced in the dentate gyrus of adult monkeys and that the rate of precursor cell proliferation can be affected by a stressful experience...
  8. ncbi request reprint Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanism
    E Gould
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Brain Res Dev Brain Res 103:91-3. 1997
    ..This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation...
  9. ncbi request reprint Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during development
    E Gould
    Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
    Brain Res Dev Brain Res 101:265-8. 1997
    ..RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration...
  10. pmc Adult-generated hippocampal and neocortical neurons in macaques have a transient existence
    E Gould
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 98:10910-7. 2001
    ..Five adult rats were injected with BrdUrd, and after a 3-wk survival time, there were cells double-labeled for BrdUrd and either TuJ1 or neuronal nuclei in the anterior neocortex as well as the dentate gyrus...
  11. ncbi request reprint Rapid extension of axons into the CA3 region by adult-generated granule cells
    N B Hastings
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    J Comp Neurol 413:146-54. 1999
    ..Collectively these results suggest that adult-generated granule neurons may influence normal hippocampal function, even at a very early stage after their production...
  12. ncbi request reprint Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanism
    P Tanapat
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    J Comp Neurol 437:496-504. 2001
    ..These findings suggest that stressful experiences rapidly diminish cell proliferation by increasing adrenal hormone levels, resulting in a transient decrease in the number of adult-generated immature granule neurons...
  13. ncbi request reprint Stress and adult neurogenesis
    Christian Mirescu
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Hippocampus 16:233-8. 2006
    ..This review considers the growing literature on this subject with specific emphasis on paradoxical findings and the role of glucocorticoids in modulating adult neurogenesis...
  14. pmc Thymidine analog methods for studies of adult neurogenesis are not equally sensitive
    Benedetta Leuner
    Department of Psychology, Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
    J Comp Neurol 517:123-33. 2009
    ....
  15. pmc Social isolation delays the positive effects of running on adult neurogenesis
    Alexis M Stranahan
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Nat Neurosci 9:526-33. 2006
    ..These results suggest that, in the absence of social interaction, a normally beneficial experience can exert a potentially deleterious influence on the brain...
  16. ncbi request reprint Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent manner
    Patima Tanapat
    Department of Psychology and Program in Neuroscience, Princeton University, Princeton, New Jersey 08544, USA
    J Comp Neurol 481:252-65. 2005
    ....
  17. ncbi request reprint Maternal experience inhibits the production of immature neurons in the hippocampus during the postpartum period through elevations in adrenal steroids
    Benedetta Leuner
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Hippocampus 17:434-42. 2007
    ..These findings indicate that offspring interactions inhibit adult neurogenesis through changes in adrenal steroids, and further suggest a potential mechanism for alterations in hippocampal function during the postpartum period...
  18. ncbi request reprint Early life experience alters response of adult neurogenesis to stress
    Christian Mirescu
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Neurosci 7:841-6. 2004
    ..Our results suggest that early adverse experience inhibits structural plasticity via hypersensitivity to glucocorticoids and diminishes the ability of the hippocampus to respond to stress in adulthood...
  19. pmc Diminished adult neurogenesis in the marmoset brain precedes old age
    Benedetta Leuner
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 104:17169-73. 2007
    ..These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain...
  20. ncbi request reprint Adult neurogenesis: a mechanism for brain repair?
    Yevgenia Kozorovitskiy
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    J Clin Exp Neuropsychol 25:721-32. 2003
    ..This review considers the evidence for compensatory neurogenesis in the adult mammalian brain with a view toward applying information from the undamaged brain to studies of regeneration...
  21. doi request reprint Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampus
    Erica R Glasper
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Hippocampus 20:706-12. 2010
    ..These results suggest that IGF-I exerts a complex influence over hippocampal structure and that its effects are not restricted to those induced by running...
  22. ncbi request reprint Granule neurons generated during development extend divergent axon collaterals to hippocampal area CA3
    Nicholas B Hastings
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    J Comp Neurol 452:324-33. 2002
    ..We conclude that a proportion of the hippocampal mossy fiber projection extends septotemporally divergent axon collaterals to hippocampal area CA3...
  23. ncbi request reprint Adrenal steroid receptor immunoreactivity in cells born in the adult rat dentate gyrus
    H A Cameron
    Laboratory of Neuroendocrinology, Rockefeller University, NY 10021
    Brain Res 611:342-6. 1993
    ..These results suggest that adrenal steroids do not act directly on granule cell progenitors in the adult rat dentate gyrus...
  24. pmc Structural plasticity and hippocampal function
    Benedetta Leuner
    Department of Psychology, Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
    Annu Rev Psychol 61:111-40, C1-3. 2010
    ..Although significant progress has been made in many of these areas, we highlight some of the outstanding issues that remain...
  25. pmc Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids
    Christian Mirescu
    Department of Psychology, Princeton University, Princeton, NJ 08544
    Proc Natl Acad Sci U S A 103:19170-5. 2006
    ..Collectively, these findings suggest that, although sleep deprivation inhibits adult neurogenesis by acting as a stressor, its compensatory aftereffects involve glucocorticoid-independent factors...
  26. pmc Sexual experience promotes adult neurogenesis in the hippocampus despite an initial elevation in stress hormones
    Benedetta Leuner
    Department of Psychology, Neuroscience Institute, Princeton University, Princeton, New Jersey, USA
    PLoS ONE 5:e11597. 2010
    ..These findings suggest that a rewarding experience not only buffers against the deleterious actions of early elevated glucocorticoids but actually promotes neuronal growth and reduces anxiety...
  27. ncbi request reprint Dominance hierarchy influences adult neurogenesis in the dentate gyrus
    Yevgenia Kozorovitskiy
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    J Neurosci 24:6755-9. 2004
    ....
  28. pmc Dendritic growth in medial prefrontal cortex and cognitive flexibility are enhanced during the postpartum period
    Benedetta Leuner
    Princeton University, Department of Psychology, Neuroscience Institute, Princeton, New Jersey 08544, USA
    J Neurosci 30:13499-503. 2010
    ..These findings suggest that the postpartum period is associated with promotion of neuronal growth in the mPFC and enhanced cognitive function...
  29. pmc Temporal discontiguity is neither necessary nor sufficient for learning-induced effects on adult neurogenesis
    Benedetta Leuner
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    J Neurosci 26:13437-42. 2006
    ..Together, these results demonstrate that associative learning increases the survival of new neurons in the adult hippocampus, regardless of temporal contiguity...
  30. pmc Running induces widespread structural alterations in the hippocampus and entorhinal cortex
    Alexis M Stranahan
    Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
    Hippocampus 17:1017-22. 2007
    ..These structural changes may contribute to running-induced changes in cognitive function...
  31. pmc Experience induces structural and biochemical changes in the adult primate brain
    Yevgenia Kozorovitskiy
    Department of Psychology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 102:17478-82. 2005
    ..For adult primates, living in standard laboratory housing may induce reversible dendritic spine and synapse decreases in brain regions important for cognition...
  32. pmc Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memory
    Bendetta Leuner
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
    J Neurosci 24:7477-81. 2004
    ....
  33. pmc Neurogenesis may relate to some but not all types of hippocampal-dependent learning
    Tracey J Shors
    Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8020, USA
    Hippocampus 12:578-84. 2002
    ..Nor did MAM treatment affect exploration in the elevated plus maze. These results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal-dependent memories...
  34. ncbi request reprint Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeys
    Christopher L Coe
    Harlow Primate Laboratory CLC, University of Wisconsin, Madison, Wisconsin, USA
    Biol Psychiatry 54:1025-34. 2003
    ..Early life stress, including during fetal development, has been hypothesized to predispose individuals to several illnesses and psychiatric disorders later in adulthood...
  35. ncbi request reprint From neurotoxin to neurotrophin
    Christian Mirescu
    Nat Neurosci 7:899-900. 2004
  36. ncbi request reprint Stem cell fusion in the brain
    Yevgenia Kozorovitskiy
    Nat Cell Biol 5:952-4. 2003
  37. ncbi request reprint Neurons inhibit neurogenesis
    Nicholas B Hastings
    Nat Med 9:264-6. 2003
  38. ncbi request reprint Preclinical models: status of basic research in depression
    Eric J Nestler
    Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
    Biol Psychiatry 52:503-28. 2002
    ....

Research Grants9

  1. ESTROGEN, HIPPOCAMPAL NEUROGENESIS AND LEARNING
    Elizabeth Gould; Fiscal Year: 2001
    ..This proposal is relevant to disorders or age- and disease-related cognitive decline which can be ameliorated by ovarian steroids. In addition, these studies may provide insight into mechanisms of neuronal regeneration. ..
  2. Hormones, Experience and Hippocampal Neurogenesis
    Elizabeth Gould; Fiscal Year: 2009
    ..abstract_text> ..