Research Topics
| E GouldSummaryAffiliation: Princeton University Country: USA Publications
Research Grants
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Detail Information
Publications
Early NMDA receptor blockade impairs defensive behavior and increases cell proliferation in the dentate gyrus of developing ratsE Gould
Laboratory of Neuroendocrinology, Rockefeller University
Behav Neurosci 111:49-56. 1997....- Is there a link between adult neurogenesis and learning?Benedetta Leuner
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
Hippocampus 16:216-24. 2006..This review discusses both sides of this issue, considering the effects of learning on the production of new neurons in the dentate gyrus and the question of whether newly born cells participate in learning and memory... - Neurogenesis in adult mammals: some progress and problemsElizabeth Gould
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
J Neurosci 22:619-23. 2002 - How widespread is adult neurogenesis in mammals?Elizabeth Gould
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
Nat Rev Neurosci 8:481-8. 2007..The discrepancies may be due to variations in the sensitivity of the methods used to detect new neurons... - Neurogenesis in the neocortex of adult primatesE Gould
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Science 286:548-52. 1999..These new neurons, which are continually added in adulthood, may play a role in the functions of association neocortex... 
Hippocampal neurogenesis in adult Old World primatesE Gould
Department of Psychology, Princeton University, Princeton NJ 08544, USA
Proc Natl Acad Sci U S A 96:5263-7. 1999..These results indicate that the adult brains of Old World monkeys produce new hippocampal neurons. Adult macaque monkeys may provide a useful primate model for studying the functional significance of adult neurogenesis...- Proliferation of granule cell precursors in the dentate gyrus of adult monkeys is diminished by stressE Gould
Department of Psychology, Princeton University, Green Hall, Princeton, NJ 08544, USA
Proc Natl Acad Sci U S A 95:3168-71. 1998..Our results suggest that neurons are produced in the dentate gyrus of adult monkeys and that the rate of precursor cell proliferation can be affected by a stressful experience... - Adrenal steroids suppress granule cell death in the developing dentate gyrus through an NMDA receptor-dependent mechanismE Gould
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
Brain Res Dev Brain Res 103:91-3. 1997..This finding suggests that adrenal steroids naturally promote granule cell survival via NMDA receptor activation... - Activation of the type 2 adrenal steroid receptor can rescue granule cells from death during developmentE Gould
Laboratory of Neuroendocrinology, Rockefeller University, New York, NY 10021, USA
Brain Res Dev Brain Res 101:265-8. 1997..RU28362 administration decreased the numbers of degenerating granule cells suggesting that type 2 receptor activation can rescue granule cells from degeneration... - Adult-generated hippocampal and neocortical neurons in macaques have a transient existenceE Gould
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Proc Natl Acad Sci U S A 98:10910-7. 2001..Five adult rats were injected with BrdUrd, and after a 3-wk survival time, there were cells double-labeled for BrdUrd and either TuJ1 or neuronal nuclei in the anterior neocortex as well as the dentate gyrus... - Rapid extension of axons into the CA3 region by adult-generated granule cellsN B Hastings
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
J Comp Neurol 413:146-54. 1999..Collectively these results suggest that adult-generated granule neurons may influence normal hippocampal function, even at a very early stage after their production... - Exposure to fox odor inhibits cell proliferation in the hippocampus of adult rats via an adrenal hormone-dependent mechanismP Tanapat
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
J Comp Neurol 437:496-504. 2001..These findings suggest that stressful experiences rapidly diminish cell proliferation by increasing adrenal hormone levels, resulting in a transient decrease in the number of adult-generated immature granule neurons... - Stress and adult neurogenesisChristian Mirescu
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
Hippocampus 16:233-8. 2006..This review considers the growing literature on this subject with specific emphasis on paradoxical findings and the role of glucocorticoids in modulating adult neurogenesis... - Thymidine analog methods for studies of adult neurogenesis are not equally sensitiveBenedetta Leuner
Department of Psychology, Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
J Comp Neurol 517:123-33. 2009.... - Social isolation delays the positive effects of running on adult neurogenesisAlexis M Stranahan
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Nat Neurosci 9:526-33. 2006..These results suggest that, in the absence of social interaction, a normally beneficial experience can exert a potentially deleterious influence on the brain... - Ovarian steroids influence cell proliferation in the dentate gyrus of the adult female rat in a dose- and time-dependent mannerPatima Tanapat
Department of Psychology and Program in Neuroscience, Princeton University, Princeton, New Jersey 08544, USA
J Comp Neurol 481:252-65. 2005.... - Maternal experience inhibits the production of immature neurons in the hippocampus during the postpartum period through elevations in adrenal steroidsBenedetta Leuner
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
Hippocampus 17:434-42. 2007..These findings indicate that offspring interactions inhibit adult neurogenesis through changes in adrenal steroids, and further suggest a potential mechanism for alterations in hippocampal function during the postpartum period... - Early life experience alters response of adult neurogenesis to stressChristian Mirescu
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
Nat Neurosci 7:841-6. 2004..Our results suggest that early adverse experience inhibits structural plasticity via hypersensitivity to glucocorticoids and diminishes the ability of the hippocampus to respond to stress in adulthood... - Diminished adult neurogenesis in the marmoset brain precedes old ageBenedetta Leuner
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Proc Natl Acad Sci U S A 104:17169-73. 2007..These data demonstrate that a substantial decrease in neurogenesis occurs before the onset of old age in the adult marmoset brain, suggesting the possibility that similar alterations occur in the human brain... - Adult neurogenesis: a mechanism for brain repair?Yevgenia Kozorovitskiy
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
J Clin Exp Neuropsychol 25:721-32. 2003..This review considers the evidence for compensatory neurogenesis in the adult mammalian brain with a view toward applying information from the undamaged brain to studies of regeneration... 
Blockade of insulin-like growth factor-I has complex effects on structural plasticity in the hippocampusErica R Glasper
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
Hippocampus 20:706-12. 2010..These results suggest that IGF-I exerts a complex influence over hippocampal structure and that its effects are not restricted to those induced by running...- Granule neurons generated during development extend divergent axon collaterals to hippocampal area CA3Nicholas B Hastings
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
J Comp Neurol 452:324-33. 2002..We conclude that a proportion of the hippocampal mossy fiber projection extends septotemporally divergent axon collaterals to hippocampal area CA3... - Adrenal steroid receptor immunoreactivity in cells born in the adult rat dentate gyrusH A Cameron
Laboratory of Neuroendocrinology, Rockefeller University, NY 10021
Brain Res 611:342-6. 1993..These results suggest that adrenal steroids do not act directly on granule cell progenitors in the adult rat dentate gyrus... - Structural plasticity and hippocampal functionBenedetta Leuner
Department of Psychology, Neuroscience Institute, Princeton University, Princeton, New Jersey 08544, USA
Annu Rev Psychol 61:111-40, C1-3. 2010..Although significant progress has been made in many of these areas, we highlight some of the outstanding issues that remain... - Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoidsChristian Mirescu
Department of Psychology, Princeton University, Princeton, NJ 08544
Proc Natl Acad Sci U S A 103:19170-5. 2006..Collectively, these findings suggest that, although sleep deprivation inhibits adult neurogenesis by acting as a stressor, its compensatory aftereffects involve glucocorticoid-independent factors... - Sexual experience promotes adult neurogenesis in the hippocampus despite an initial elevation in stress hormonesBenedetta Leuner
Department of Psychology, Neuroscience Institute, Princeton University, Princeton, New Jersey, USA
PLoS ONE 5:e11597. 2010..These findings suggest that a rewarding experience not only buffers against the deleterious actions of early elevated glucocorticoids but actually promotes neuronal growth and reduces anxiety... - Dominance hierarchy influences adult neurogenesis in the dentate gyrusYevgenia Kozorovitskiy
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
J Neurosci 24:6755-9. 2004.... - Dendritic growth in medial prefrontal cortex and cognitive flexibility are enhanced during the postpartum periodBenedetta Leuner
Princeton University, Department of Psychology, Neuroscience Institute, Princeton, New Jersey 08544, USA
J Neurosci 30:13499-503. 2010..These findings suggest that the postpartum period is associated with promotion of neuronal growth in the mPFC and enhanced cognitive function... - Temporal discontiguity is neither necessary nor sufficient for learning-induced effects on adult neurogenesisBenedetta Leuner
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
J Neurosci 26:13437-42. 2006..Together, these results demonstrate that associative learning increases the survival of new neurons in the adult hippocampus, regardless of temporal contiguity... - Running induces widespread structural alterations in the hippocampus and entorhinal cortexAlexis M Stranahan
Department of Psychology, Princeton University, Princeton, New Jersey 08544, USA
Hippocampus 17:1017-22. 2007..These structural changes may contribute to running-induced changes in cognitive function... - Experience induces structural and biochemical changes in the adult primate brainYevgenia Kozorovitskiy
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Proc Natl Acad Sci U S A 102:17478-82. 2005..For adult primates, living in standard laboratory housing may induce reversible dendritic spine and synapse decreases in brain regions important for cognition... - Learning enhances the survival of new neurons beyond the time when the hippocampus is required for memoryBendetta Leuner
Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854, USA
J Neurosci 24:7477-81. 2004.... - Neurogenesis may relate to some but not all types of hippocampal-dependent learningTracey J Shors
Department of Psychology and Center for Collaborative Neuroscience, Rutgers University, Piscataway, New Jersey 08854 8020, USA
Hippocampus 12:578-84. 2002..Nor did MAM treatment affect exploration in the elevated plus maze. These results combined with previous ones suggest that neurogenesis may be associated with the formation of some but not all types of hippocampal-dependent memories... - Prenatal stress diminishes neurogenesis in the dentate gyrus of juvenile rhesus monkeysChristopher L Coe
Harlow Primate Laboratory (CLC, University of Wisconsin, Madison, Wisconsin, USA
Biol Psychiatry 54:1025-34. 2003..CONCLUSIONS: These findings indicate that the prenatal environment can alter behavior, dysregulate neuroendocrine systems, and affect the hippocampal structure of primates in a persistent manner... - From neurotoxin to neurotrophinChristian Mirescu
Nat Neurosci 7:899-900. 2004 - Stem cell fusion in the brainYevgenia Kozorovitskiy
Nat Cell Biol 5:952-4. 2003 - Neurons inhibit neurogenesisNicholas B Hastings
Nat Med 9:264-6. 2003 - Preclinical models: status of basic research in depressionEric J Nestler
Department of Psychiatry and Center for Basic Neuroscience, The University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA
Biol Psychiatry 52:503-28. 2002....
Research Grants
- ESTROGEN, HIPPOCAMPAL NEUROGENESIS AND LEARNINGElizabeth Gould; Fiscal Year: 2001..This proposal is relevant to disorders or age- and disease-related cognitive decline which can be ameliorated by ovarian steroids. In addition, these studies may provide insight into mechanisms of neuronal regeneration. ..
- Hormones, Experience and Hippocampal NeurogenesisElizabeth Gould; Fiscal Year: 2009..abstract_text> ..