Lynn Enquist

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc UL54-null pseudorabies virus is attenuated in mice but productively infects cells in culture
    Jennifer A Schwartz
    Department of Microbiology, Columbia University, 701 W 168th St, New York, NY 10032, USA
    J Virol 80:769-84. 2006
  2. pmc Directional spread of alphaherpesviruses in the nervous system
    Tal Kramer
    Princeton University, Department of Molecular Biology, Princeton, NJ 08544, USA
    Viruses 5:678-707. 2013
  3. ncbi request reprint Recent advances in the use of neurotropic viruses for circuit analysis
    Lynn W Enquist
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Curr Opin Neurobiol 13:603-6. 2003
  4. pmc Alpha-herpesvirus infection induces the formation of nuclear actin filaments
    Becket Feierbach
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Pathog 2:e85. 2006
  5. ncbi request reprint Suprachiasmatic nucleus input to autonomic circuits identified by retrograde transsynaptic transport of pseudorabies virus from the eye
    Cynthia A Smeraski
    Department of Biomedical Sciences, Section of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Comp Neurol 471:298-313. 2004
  6. pmc Transcriptome signature of virulent and attenuated pseudorabies virus-infected rodent brain
    Christina Paulus
    Department of Molecular Biology, Princeton University, Princeton, NJ08544 1014, USA
    J Virol 80:1773-86. 2006
  7. ncbi request reprint Brainstem substrates of sympatho-motor circuitry identified using trans-synaptic tracing with pseudorabies virus recombinants
    Ilan A Kerman
    Department of Neuroscience University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:4657-66. 2003
  8. ncbi request reprint Pseudorabies virus-induced expression of nitric oxide synthase isoforms
    Faridis Serrano
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:557-63. 2002
  9. pmc Physical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49
    Walter Fuchs
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17498 Insel Riems, Germany
    J Virol 76:8208-17. 2002
  10. pmc Targeting of pseudorabies virus structural proteins to axons requires association of the viral Us9 protein with lipid rafts
    Mathew G Lyman
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 4:e1000065. 2008

Research Grants

  1. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2010
  2. Neuronal Spread of Herpesvirus Infection
    Lynn Enquist; Fiscal Year: 2009
  3. GENETIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCE
    Lynn Enquist; Fiscal Year: 2007
  4. GENERTIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCE
    Lynn Enquist; Fiscal Year: 2004
  5. Viruses And Cells Gordon Conference
    Lynn Enquist; Fiscal Year: 2003
  6. GENETIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCE
    Lynn Enquist; Fiscal Year: 1999
  7. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2010

Collaborators

Detail Information

Publications21

  1. pmc UL54-null pseudorabies virus is attenuated in mice but productively infects cells in culture
    Jennifer A Schwartz
    Department of Microbiology, Columbia University, 701 W 168th St, New York, NY 10032, USA
    J Virol 80:769-84. 2006
    ..Animals infected with vJSdelta54 survive twice as long as animals infected with wild-type virus, and this results in delayed accumulation of virus-specific antigens in skin, dorsal root ganglia, and spinal cord tissues...
  2. pmc Directional spread of alphaherpesviruses in the nervous system
    Tal Kramer
    Princeton University, Department of Molecular Biology, Princeton, NJ 08544, USA
    Viruses 5:678-707. 2013
    ..We focus on the molecular events that mediate long distance directional transport of viral particles in neurons during entry and egress...
  3. ncbi request reprint Recent advances in the use of neurotropic viruses for circuit analysis
    Lynn W Enquist
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Curr Opin Neurobiol 13:603-6. 2003
    ....
  4. pmc Alpha-herpesvirus infection induces the formation of nuclear actin filaments
    Becket Feierbach
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, USA
    PLoS Pathog 2:e85. 2006
    ..Our results suggest a mechanism by which assembly domains are organized within infected cells and provide insight into how the viral infectious cycle and host actin cytoskeleton are integrated to promote the infection process...
  5. ncbi request reprint Suprachiasmatic nucleus input to autonomic circuits identified by retrograde transsynaptic transport of pseudorabies virus from the eye
    Cynthia A Smeraski
    Department of Biomedical Sciences, Section of Anatomy and Neurobiology, Colorado State University, Fort Collins, Colorado 80523, USA
    J Comp Neurol 471:298-313. 2004
    ..The results indicate that in the rat, as in the hamster, SCN infection after intraocular PRV152 inoculation is by retrograde transsynaptic transport via autonomic pathways to the eye...
  6. pmc Transcriptome signature of virulent and attenuated pseudorabies virus-infected rodent brain
    Christina Paulus
    Department of Molecular Biology, Princeton University, Princeton, NJ08544 1014, USA
    J Virol 80:1773-86. 2006
    ..The differentially regulated genes reported here are likely to include potential diagnostic and therapeutic targets for viral encephalitides and other neurodegenerative or neuroinflammatory diseases...
  7. ncbi request reprint Brainstem substrates of sympatho-motor circuitry identified using trans-synaptic tracing with pseudorabies virus recombinants
    Ilan A Kerman
    Department of Neuroscience University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
    J Neurosci 23:4657-66. 2003
    ..These neurons are candidates for relaying central command signals to the spinal cord...
  8. ncbi request reprint Pseudorabies virus-induced expression of nitric oxide synthase isoforms
    Faridis Serrano
    Department of Neuroscience, University of Pittsburgh, 446 Crawford Hall, 15260, Pittsburgh, PA, USA
    Physiol Behav 77:557-63. 2002
    ..Collectively, these data suggest functionally diverse roles for NO in the brain response to PRV neuronal infection...
  9. pmc Physical interaction between envelope glycoproteins E and M of pseudorabies virus and the major tegument protein UL49
    Walter Fuchs
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17498 Insel Riems, Germany
    J Virol 76:8208-17. 2002
    ..In summary, we describe specific interactions between herpesvirus envelope and tegument proteins which may play a role in secondary envelopment during herpesvirus virion maturation...
  10. pmc Targeting of pseudorabies virus structural proteins to axons requires association of the viral Us9 protein with lipid rafts
    Mathew G Lyman
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 4:e1000065. 2008
    ....
  11. ncbi request reprint Functional integration of adult-born neurons
    Marie Carlen
    Department of Cell and Molecular Biology, Medical Nobel Institute, Stockholm, Sweden
    Curr Biol 12:606-8. 2002
    ..Here, we use virus-based transsynaptic neuronal tracing and c-Fos mapping of odor-induced neuronal activity to demonstrate that neurons generated in the adult functionally integrate into the synaptic circuitry of the brain...
  12. ncbi request reprint Intravitreal injection of the attenuated pseudorabies virus PRV Bartha results in infection of the hamster suprachiasmatic nucleus only by retrograde transsynaptic transport via autonomic circuits
    Gary E Pickard
    Department of Anatomy, Colorado State University, Fort Collins, Colorado 80523, USA
    J Neurosci 22:2701-10. 2002
    ..These results, taken together with other genetic data, indicate that the mutations in PRV Bartha render the virus incapable of anterograde transport. PRV Bartha is thus a retrograde transsynaptic marker in the CNS...
  13. pmc Herpes simplex virus type 1 glycoprotein e is required for axonal localization of capsid, tegument, and membrane glycoproteins
    Fushan Wang
    Department of Medicine, Division of Infectious Diseases, 502 Johnson Pavilion, University of Pennsylvania, Philadelphia, PA 19104 6073, USA
    J Virol 79:13362-72. 2005
    ..The requirement for gE in axonal targeting and retrograde spread highlights intriguing similarities and differences between HSV-1 and pseudorabies virus gE...
  14. ncbi request reprint Local retinal circuits of melanopsin-containing ganglion cells identified by transsynaptic viral tracing
    Tim James Viney
    Neural Circuit Laboratories, Friedrich Miescher Institute, Maulbeerstrasse 66, Basel 4058, Switzerland
    Curr Biol 17:981-8. 2007
    ..Second, we show evidence that dopaminergic interplexiform cells are synaptically connected to ipRGCs. The latter finding provides a circuitry link between light-dark adaptation and ipRGC function...
  15. ncbi request reprint New developments in tracing neural circuits with herpesviruses
    C Kay Song
    Department of Biology, Neurobiology and Behavior Program, Georgia State University, 24 Peachtree Center Ave NE, Atlanta, GA 30302 4010, USA
    Virus Res 111:235-49. 2005
    ..We provide examples of these combined application techniques within the context of an animal model to study the naturally occurring reversal of seasonal obesity in Siberian hamsters...
  16. ncbi request reprint The pseudorabies virus US3 protein kinase possesses anti-apoptotic activity that protects cells from apoptosis during infection and after treatment with sorbitol or staurosporine
    Kristin Geenen
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisbury laan 133, 9820 Merelbeke, East Flanders, Belgium
    Virology 331:144-50. 2005
    ....
  17. pmc Complete, annotated sequence of the pseudorabies virus genome
    Barbara G Klupp
    Institute of Molecular Biology, Friedrich Loeffler Institutes, Federal Research Centre for Virus Diseases of Animals, D 17493 Greifswald Insel Riems, Germany
    J Virol 78:424-40. 2004
    ..Many of these features are conserved in the alphaherpesvirus subfamily and have important implications for gene array analyses...
  18. ncbi request reprint Break ins and break outs: viral interactions with the cytoskeleton of Mammalian cells
    Gregory A Smith
    Department of Microbiology Immunology, Northwestern University Medical School, Chicago, Illinois 60611, USA
    Annu Rev Cell Dev Biol 18:135-61. 2002
    ..Understanding these interactions, and their orchestration during viral infections, is providing unexpected insights into basic virology, viral pathogenesis, and the biology of the cytoskeleton...
  19. pmc In vivo egress of an alphaherpesvirus from axons
    Mark J Tomishima
    Department of Molecular Biology, Princeton University, New Jersey 08544, USA
    J Virol 76:8310-7. 2002
    ..Taking these together with previous data, we suggest a model of viral egress from neurons that unifies previous apparently contradictory data...
  20. pmc A tyrosine-based motif in the cytoplasmic tail of pseudorabies virus glycoprotein B is important for both antibody-induced internalization of viral glycoproteins and efficient cell-to-cell spread
    Herman W Favoreel
    Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, 9820 Merelbeke, Belgium
    J Virol 76:6845-51. 2002
    ..Mutating the dileucine motif in the gB tail led to an increased cell-to-cell spread of the virus and the formation of large syncytia...
  21. pmc Construction of a self-excisable bacterial artificial chromosome containing the human cytomegalovirus genome and mutagenesis of the diploid TRL/IRL13 gene
    Dong Yu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544 1014, USA
    J Virol 76:2316-28. 2002
    ..This view is consistent with the presence of both TRL13 and -14 on all mRNAs that we have mapped from this region, an organization that would include the much longer strain Toledo TRL13 open reading frame on the mRNAs...

Research Grants19

  1. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2010
    ..These neural tracers would be powerful tools to elucidate brain micro-circuitry, providing a better understanding of nervous system functions. ..
  2. Neuronal Spread of Herpesvirus Infection
    Lynn Enquist; Fiscal Year: 2009
    ..These neural tracers would be powerful tools to elucidate brain micro-circuitry, providing a better understanding of nervous system functions. ..
  3. GENETIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCE
    Lynn Enquist; Fiscal Year: 2007
    ..The goal is to identify and characterize the PRV genes whose products stimulate abnormal and persistent neuronal firing of peripheral nervous system neurons. ..
  4. GENERTIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCE
    Lynn Enquist; Fiscal Year: 2004
    ..abstract_text> ..
  5. Viruses And Cells Gordon Conference
    Lynn Enquist; Fiscal Year: 2003
    ..This conference is one of the few smaller meetings in virology that encompasses a broad view of the field. Funding is requested to support the registration and travel of graduate students and postdoctoral fellows to this meeting. ..
  6. GENETIC ANALYSIS OF HERPESVIRUS TROPISM AND VIRULENCE
    Lynn Enquist; Fiscal Year: 1999
    ..A clear genetic definition of functional domains in the gE and gI proteins will give significant insight into molecular mechanisms of tropism and pathogenesis. ..
  7. Neuronal Spread of Herpesvirus Infection
    Lynn W Enquist; Fiscal Year: 2010
    ..These neural tracers would be powerful tools to elucidate brain micro-circuitry, providing a better understanding of nervous system functions. ..