Olivier Elemento

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Genome Biol 6:R18. 2005
  2. pmc A universal framework for regulatory element discovery across all genomes and data types
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 28:337-50. 2007
  3. pmc Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite
    Tracey L Campbell
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 6:e1001165. 2010
  4. ncbi request reprint Fastcompare: a nonalignment approach for genome-scale discovery of DNA and mRNA regulatory elements using network-level conservation
    Olivier Elemento
    Department of Molecular Biology, Princeton University, USA
    Methods Mol Biol 395:349-66. 2007
  5. pmc Revealing global regulatory perturbations across human cancers
    Hani Goodarzi
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 36:900-11. 2009
  6. pmc Large-scale discovery and characterization of protein regulatory motifs in eukaryotes
    Daniel S Lieber
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 5:e14444. 2010
  7. pmc Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo
    Stefano de Renzis
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey, United States of America
    PLoS Biol 5:e117. 2007
  8. pmc Revealing posttranscriptional regulatory elements through network-level conservation
    Chang S Chan
    Department of Molecular Biology and The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    PLoS Comput Biol 1:e69. 2005
  9. pmc let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts
    Aster Legesse-Miller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 284:6605-9. 2009
  10. pmc Developing a systems-level understanding of gene expression
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Genome Biol 8:304. 2007

Collaborators

Detail Information

Publications13

  1. pmc Fast and systematic genome-wide discovery of conserved regulatory elements using a non-alignment based approach
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Genome Biol 6:R18. 2005
    ..Many of these are validated by independent biological observations, have spatial and/or orientation biases, are co-conserved with other elements and show surprising conservation across large phylogenetic distances...
  2. pmc A universal framework for regulatory element discovery across all genomes and data types
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 28:337-50. 2007
    ....
  3. pmc Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite
    Tracey L Campbell
    Department of Molecular Biology and Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 6:e1001165. 2010
    ..Our results offer a detailed view of ApiAP2 DNA binding specificity and take the first step toward inferring comprehensive gene regulatory networks for P. falciparum...
  4. ncbi request reprint Fastcompare: a nonalignment approach for genome-scale discovery of DNA and mRNA regulatory elements using network-level conservation
    Olivier Elemento
    Department of Molecular Biology, Princeton University, USA
    Methods Mol Biol 395:349-66. 2007
    ....
  5. pmc Revealing global regulatory perturbations across human cancers
    Hani Goodarzi
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mol Cell 36:900-11. 2009
    ..Our study provides a systems-level dissection of regulatory perturbations in cancer-an essential component of a rational strategy for therapeutic intervention and drug-target discovery...
  6. pmc Large-scale discovery and characterization of protein regulatory motifs in eukaryotes
    Daniel S Lieber
    Department of Molecular Biology, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS ONE 5:e14444. 2010
    ..These predicted motifs, many of which display preferential association with specific biological pathways and non-random positioning in the linear protein sequence, provide focused hypotheses for experimental validation...
  7. pmc Unmasking activation of the zygotic genome using chromosomal deletions in the Drosophila embryo
    Stefano de Renzis
    Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University, New Jersey, United States of America
    PLoS Biol 5:e117. 2007
    ..We propose that this regulatory mode links morphogen gradients with temporal regulation during the maternal-to-zygotic transition...
  8. pmc Revealing posttranscriptional regulatory elements through network-level conservation
    Chang S Chan
    Department of Molecular Biology and The Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, USA
    PLoS Comput Biol 1:e69. 2005
    ..We also provide evidence that posttranscriptional networks have undergone extensive rewiring across distant phyla, despite strong conservation of regulatory elements themselves...
  9. pmc let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts
    Aster Legesse-Miller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 284:6605-9. 2009
    ..We conclude that Cdc34 is a functional target of let-7 and that let-7 induces down-regulation of Cdc34, stabilization of the Wee1 kinase, and an increased fraction of cells in G(2)/M in primary fibroblasts...
  10. pmc Developing a systems-level understanding of gene expression
    Olivier Elemento
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Genome Biol 8:304. 2007
  11. pmc Coupling of zygotic transcription to mitotic control at the Drosophila mid-blastula transition
    Xuemin Lu
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Development 136:2101-10. 2009
    ....
  12. pmc Ab initio genotype-phenotype association reveals intrinsic modularity in genetic networks
    Noam Slonim
    Department of Physics, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 2:2006.0005. 2006
    ....
  13. ncbi request reprint An efficient and accurate distance based algorithm to reconstruct tandem duplication trees
    Olivier Elemento
    D├ępartement d Informatique Fondamentale et Applications, LIRMM, Montpellier, France
    Bioinformatics 18:S92-9. 2002
    ..The results clearly show that DTSCORE is more accurate than all the other methods we studied. Finally, we report the results of DTSCORE on a real dataset. Supplementary information: http://www.lirmm.fr/w3ifa/MAAS/..