HILARY COLLER

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival
    Daniel L Miller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Genome Biol 8:R58. 2007
  2. pmc Nearest Neighbor Networks: clustering expression data based on gene neighborhoods
    Curtis Huttenhower
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    BMC Bioinformatics 8:250. 2007
  3. pmc "Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron
    Hilary A Coller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 3:e146. 2007
  4. doi request reprint Genetics. It's the sequence, stupid!
    Hilary A Coller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 322:380-1. 2008
  5. ncbi request reprint What's taking so long? S-phase entry from quiescence versus proliferation
    Hilary A Coller
    Department of Molecular Biology, Lewis Thomas Laboratory, Room 140, Princeton University, Princeton, New Jersey 08544 1014, USA
    Nat Rev Mol Cell Biol 8:667-70. 2007
  6. pmc Detailing regulatory networks through large scale data integration
    Curtis Huttenhower
    Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08540, USA
    Bioinformatics 25:3267-74. 2009
  7. pmc A new description of cellular quiescence
    Hilary A Coller
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 4:e83. 2006
  8. ncbi request reprint Clustering of mutant mitochondrial DNA copies suggests stem cells are common in human bronchial epithelium
    Hilary A Coller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mutat Res 578:256-71. 2005
  9. pmc Exploring the human genome with functional maps
    Curtis Huttenhower
    Department of Computer Science, Princeton University, Princeton, New Jersey 08540, USA
    Genome Res 19:1093-106. 2009
  10. pmc let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts
    Aster Legesse-Miller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 284:6605-9. 2009

Collaborators

Detail Information

Publications18

  1. pmc Adenovirus type 5 exerts genome-wide control over cellular programs governing proliferation, quiescence, and survival
    Daniel L Miller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Genome Biol 8:R58. 2007
    ..However, a global view of the effects of Ad5 infection on such programs in normal human cells is not available, despite widespread efforts to develop adenoviruses for therapeutic applications...
  2. pmc Nearest Neighbor Networks: clustering expression data based on gene neighborhoods
    Curtis Huttenhower
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    BMC Bioinformatics 8:250. 2007
    ..g. ribosomes)...
  3. pmc "Myc'ed messages": myc induces transcription of E2F1 while inhibiting its translation via a microRNA polycistron
    Hilary A Coller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 3:e146. 2007
    ..We consider the possibility that members of this polycistronic microRNA cluster help cells to integrate signals from the environment and decide whether a signal should be interpreted as proliferative or apoptotic...
  4. doi request reprint Genetics. It's the sequence, stupid!
    Hilary A Coller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Science 322:380-1. 2008
  5. ncbi request reprint What's taking so long? S-phase entry from quiescence versus proliferation
    Hilary A Coller
    Department of Molecular Biology, Lewis Thomas Laboratory, Room 140, Princeton University, Princeton, New Jersey 08544 1014, USA
    Nat Rev Mol Cell Biol 8:667-70. 2007
    ..More than 20 years after this initial observation, we still do not understand what is taking so long...
  6. pmc Detailing regulatory networks through large scale data integration
    Curtis Huttenhower
    Department of Computer Science, Princeton University, 35 Olden Street, Princeton, NJ 08540, USA
    Bioinformatics 25:3267-74. 2009
    ..Part of this system can be modeled as a collection of regulatory modules: co-regulated genes, the conditions under which they are co-regulated and sequence-level regulatory motifs...
  7. pmc A new description of cellular quiescence
    Hilary A Coller
    Department of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    PLoS Biol 4:e83. 2006
    ..These studies form a basis for understanding the normal biology of cellular quiescence...
  8. ncbi request reprint Clustering of mutant mitochondrial DNA copies suggests stem cells are common in human bronchial epithelium
    Hilary A Coller
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Mutat Res 578:256-71. 2005
    ..These expanded turnover units suggest the bronchial epithelium may contain large clusters of cells with mutations, and possibly phenotypic alterations as well...
  9. pmc Exploring the human genome with functional maps
    Curtis Huttenhower
    Department of Computer Science, Princeton University, Princeton, New Jersey 08540, USA
    Genome Res 19:1093-106. 2009
    ..Our functional maps can be explored using HEFalMp (Human Experimental/Functional Mapper), a web interface allowing interactive visualization and investigation of this large body of information...
  10. pmc let-7 Overexpression leads to an increased fraction of cells in G2/M, direct down-regulation of Cdc34, and stabilization of Wee1 kinase in primary fibroblasts
    Aster Legesse-Miller
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    J Biol Chem 284:6605-9. 2009
    ..We conclude that Cdc34 is a functional target of let-7 and that let-7 induces down-regulation of Cdc34, stabilization of the Wee1 kinase, and an increased fraction of cells in G(2)/M in primary fibroblasts...
  11. pmc A search for conserved sequences in coding regions reveals that the let-7 microRNA targets Dicer within its coding sequence
    Joshua J Forman
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Proc Natl Acad Sci U S A 105:14879-84. 2008
    ..As more genomes are sequenced, the methodological approach that we used for identifying motifs with high sequence conservation will be increasingly valuable for detecting functional sequence motifs within coding regions...
  12. pmc Regulating the angiogenic balance in tissues
    Elizabeth A Pollina
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Cell Cycle 7:2056-70. 2008
    ..This work takes a new approach to the study of angiogenesis by examining the expression of multiple angiogenesis regulators secreted from a key stromal cell, the fibroblast...
  13. pmc Dynamics of the cellular metabolome during human cytomegalovirus infection
    Joshua Munger
    Department of Molecular Biology, Princeton University, Princeton, New Jersey, United States of America
    PLoS Pathog 2:e132. 2006
    ....
  14. pmc An immunohistochemical method for identifying fibroblasts in formalin-fixed, paraffin-embedded tissue
    Tracy Goodpaster
    Department of Molecular Biology, Lewis Thomas Laboratory, Room 140, Princeton University, Princeton, NJ 08544, USA
    J Histochem Cytochem 56:347-58. 2008
    ..We also present its staining patterns in normal tissue samples and in breast tumors...
  15. ncbi request reprint Telomerase modulates expression of growth-controlling genes and enhances cell proliferation
    Laura L Smith
    Howard Hughes Medical Institute and Dept of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Nat Cell Biol 5:474-9. 2003
    ..We conclude that telomerase may affect proliferation of epithelial cells not only by stabilizing telomeres, but also by affecting the expression of growth-promoting genes...
  16. pmc Control of the reversibility of cellular quiescence by the transcriptional repressor HES1
    Liyun Sang
    Division of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA
    Science 321:1095-100. 2008
    ..We conclude that HES1 safeguards against irreversible cell cycle exit both during normal cellular quiescence and pathologically in the setting of tumorigenesis...
  17. ncbi request reprint Origins of human mitochondrial point mutations as DNA polymerase gamma-mediated errors
    Weiming Zheng
    Biological Engineering Division, Massachusetts Institute of Technology, Cambridge, 02139, USA
    Mutat Res 599:11-20. 2006
    ..For the sequence studied, these data support the conclusion that, endogenous error mediated by DNA pol gamma constitutes the primary source of mitochondrial point mutations in human tissues...
  18. ncbi request reprint Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms
    Hilary A Coller
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98119, USA
    Ann N Y Acad Sci 959:434-47. 2002
    ..This suggests that the mechanisms of expansion in these tissues are different. In particular, we propose random segregation and positive selection models for epithelial and muscle cells, respectively...

Research Grants5

  1. A Combined Computational and Experimental Approach to Defining Mechanisms of micr
    HILARY COLLER; Fiscal Year: 2009
    ..We anticipate that these findings will be of great value to researchers in a wide range of fields working to identify miRNAs targets, and those designing miRNAs as therapeutics. ..
  2. The Role of MicroRNAs in Cellular Quiescence
    HILARY COLLER; Fiscal Year: 2009
    ..We propose here to characterize the role of one specific signaling pathway central to quiescence, and expect that the mechanisms identified will provide important insights into a wide range of medical conditions. ..
  3. A Combined Computational and Experimental Approach to Defining Mechanisms of micr
    Hilary A Coller; Fiscal Year: 2010
    ..We anticipate that these findings will be of great value to researchers in a wide range of fields working to identify miRNAs targets, and those designing miRNAs as therapeutics. ..
  4. The Role of MicroRNAs in Cellular Quiescence
    Hilary A Coller; Fiscal Year: 2010
    ..We propose here to characterize the role of one specific signaling pathway central to quiescence, and expect that the mechanisms identified will provide important insights into a wide range of medical conditions. ..