Research Topics
| J D CohenSummaryAffiliation: Princeton University Country: USA Publications
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Publications
Computational perspectives on dopamine function in prefrontal cortexJonathan D Cohen
Department of Psychology, Princeton University, Princeton, New Jersey 08540, USA
Curr Opin Neurobiol 12:223-9. 2002..Recently, computational models have tried to elucidate the specific and intricate roles of dopamine in the prefrontal cortex, at the neurophysiological, system and behavioral levels, with varying degrees of success...
Should I stay or should I go? How the human brain manages the trade-off between exploitation and explorationJonathan D Cohen
Department of Psychology and Center for the Study of Brain, Mind and Behaviour, Princeton University, Princeton, NJ 08540, USA
Philos Trans R Soc Lond B Biol Sci 362:933-42. 2007..Here, we provide a brief review of this work, discuss how exploration and exploitation may be mediated in the brain and highlight some promising future directions for research...- Context-processing deficits in schizophrenia: converging evidence from three theoretically motivated cognitive tasksJ D Cohen
Department of Psychiatry, University of Pittsburgh, USA
J Abnorm Psychol 108:120-33. 1999..The significance of these findings is discussed with regard to the specificity of deficits in schizophrenia and the hypothesis concerning the neural and cognitive mechanisms that underlie these deficits... - Reward and decisionJonathan D Cohen
Department of Psychology and Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
Neuron 36:193-8. 2002 - Cognitive neuroscience and schizophrenia: translational research in need of a translatorJonathan D Cohen
Department of Psychology and Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA
Biol Psychiatry 64:2-3. 2008 - Dissociating working memory from task difficulty in human prefrontal cortexD M Barch
Department of Psychiatry, University of Pittsburgh, PA 15213, USA
Neuropsychologia 35:1373-80. 1997..Thus, this study established a double-dissociation between regions responsive to WM versus task difficulty, indicating a specific involvement of DLPFC and related structures in WM function... - Anterior cingulate gyrus dysfunction and selective attention deficits in schizophrenia: [15O]H2O PET study during single-trial Stroop task performanceC S Carter
Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, PA 15213, USA
Am J Psychiatry 154:1670-5. 1997..The authors investigated the function of the anterior cingulate gyrus and the related neural systems that are associated with selective attention in patients with schizophrenia... - Selective deficits in prefrontal cortex function in medication-naive patients with schizophreniaD M Barch
Department of Psychology, Campus Box 1125, 1 Brookings Dr, Washington University, St Louis, MO 63130, USA
Arch Gen Psychiatry 58:280-8. 2001..We use functional magnetic resonance imaging to examine PFC activation in medication-naive, first-episode patients with schizophrenia during a WM, task-isolating context processing... - Anterior cingulate cortex, error detection, and the online monitoring of performanceC S Carter
Western Psychiatric Institute and Clinic, School of Medicine, University of Pittsburgh, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Science 280:747-9. 1998..This suggests that the ACC detects conditions under which errors are likely to occur rather than errors themselves... - Specificity of prefrontal dysfunction and context processing deficits to schizophrenia in never-medicated patients with first-episode psychosisAngus W MacDonald
Department of Psychology, University of Minnesota, N219 Elliott Hall, 75 E River Rd, Minneapolis, MN 55455, USA
Am J Psychiatry 162:475-84. 2005.... 
Distinct neural substrates for deductive and mathematical processingJames K Kroger
Department of Psychology, New Mexico State University, 220 Science Hall, Las Cruces, NM 88003, USA
Brain Res 1243:86-103. 2008..Different sorts of thinking recruit separate neural substrates, and logical reasoning goes beyond linguistic regions of the brain...- Do humans produce the speed-accuracy trade-off that maximizes reward rate?Rafal Bogacz
Center for the Study of Brain, Mind and Behavior, and Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ, USA
Q J Exp Psychol (Hove) 63:863-91. 2010.... - Lateral and medial hypofrontality in first-episode schizophrenia: functional activity in a medication-naive state and effects of short-term atypical antipsychotic treatmentBeth E Snitz
Department of Psychiatry, University of Pittsburgh Medical School, USA
Am J Psychiatry 162:2322-9. 2005..These findings are consistent with an emerging literature documenting short-term benefits of atypical antipsychotic medication for the neural circuitry underlying cognitive deficits in schizophrenia... - Semantic priming in schizophrenia: an examination of spreading activation using word pronunciation and multiple SOAsD M Barch
Department of Psychiatry, Western Psychiatric Institute and Clinic, Pittsburgh, Pennsylvania 15213, USA
J Abnorm Psychol 105:592-601. 1996..The failure of SCZ to display significant priming at the 950-ms SOA is consistent with a hypothesized disturbance in higher level processes... - Temporal dynamics of brain activation during a working memory taskJ D Cohen
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Nature 386:604-8. 1997..We used the temporal resolution of this technique to examine the dynamics of regional activation, and to show that prefrontal cortex along with parietal cortex appears to play a role in active maintenance... - Resting anterior cingulate activity and abnormal responses to errors in subjects with elevated depressive symptoms: a 128-channel EEG studyDiego A Pizzagalli
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138, USA
Hum Brain Mapp 27:185-201. 2006..Because rostral ACC regions have been implicated in treatment response in depression, our findings provide initial insight into putative mechanisms fostering treatment response... - Increased stroop facilitation effects in schizophrenia are not due to increased automatic spreading activationD M Barch
Department of Psychiatry, University of Pittsburgh Medical School, PA 15213, USA
Schizophr Res 39:51-64. 1999..These results are inconsistent with the spreading activation hypothesis. Alternative hypotheses regarding the source of Stroop task performance deficits in schizophrenia are discussed... - Functional hypofrontality and working memory dysfunction in schizophreniaC S Carter
Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinic, PA 15213, USA
Am J Psychiatry 155:1285-7. 1998..Inconsistencies in the literature may reflect, in part, the fact that abnormal physiological responses in the prefrontal cortex are best identified under conditions that place well-specified functional demands on this region... - The neural basis of error detection: conflict monitoring and the error-related negativityNick Yeung
Department of Psychology, Princeton University, Princeton, NJ, USA
Psychol Rev 111:931-59. 2004..It is concluded that the ERN can be explained in terms of response conflict and that monitoring for conflict may provide a simple mechanism for detecting errors... - Sensitivity of electrophysiological activity from medial frontal cortex to utilitarian and performance feedbackSander Nieuwenhuis
Department of Psychology, Princeton University, NJ, USA
Cereb Cortex 14:741-7. 2004..The results are consistent with the view that the two components are manifestations of the same underlying cognitive and neural process... - Altered emotional interference processing in affective and cognitive-control brain circuitry in major depressionChristina L Fales
Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, USA
Biol Psychiatry 63:377-84. 2008.... - The neural basis of economic decision-making in the Ultimatum GameAlan G Sanfey
Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
Science 300:1755-8. 2003..Further, significantly heightened activity in anterior insula for rejected unfair offers suggests an important role for emotions in decision-making... - Conflict monitoring and cognitive controlM M Botvinick
Department of Psychology, Carnegie Mellon University, Pennsylvania, USA
Psychol Rev 108:624-52. 2001..The second study implements a feedback loop connecting conflict monitoring to cognitive control, using this to simulate a number of important behavioral phenomena... - Pupil diameter tracks changes in control state predicted by the adaptive gain theory of locus coeruleus functionMark S Gilzenrat
Princeton University, Princeton, New Jersey
Cogn Affect Behav Neurosci 10:252-69. 2010..Findings in three experiments were consistent with these predictions, suggesting that pupillometry may be useful as an index of both control state and, indirectly, locus coeruleus function... - Prefrontal cortex and dynamic categorization tasks: representational organization and neuromodulatory controlRandall C O'Reilly
Department of Psychology, University of Colorado, Boulder, CO 80309, USA
Cereb Cortex 12:246-57. 2002..with orbital versus dorsolateral lesions supports the validity of these principles, many of which have also been useful in accounting for other frontal phenomena... - ERP correlates of feedback and reward processing in the presence and absence of response choiceNick Yeung
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Cereb Cortex 15:535-44. 2005.... - Between-task competition and cognitive control in task switchingNick Yeung
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
J Neurosci 26:1429-38. 2006..These findings provide support for theories that propose a control hierarchy comprising regions responsible for maintaining task-specific information about rules or goals, and regions involved in the coordination of these goals... - Stimulus modality, perceptual overlap, and the go/no-go N2Sander Nieuwenhuis
Department of Psychology, Princeton University, Princeton, New Jersey, USA
Psychophysiology 41:157-60. 2004..These findings are discussed in terms of existing hypotheses of the N2, and clarify why previous studies have not found an N2 modulation in auditory go/no-go tasks... - Mechanisms underlying dependencies of performance on stimulus history in a two-alternative forced-choice taskRaymond Y Cho
Princeton University, Princeton, New Jersey, USA
Cogn Affect Behav Neurosci 2:283-99. 2002.... - Updating of context in working memory: an event-related potential studyAgatha Lenartowicz
Princeton University, Princeton, New Jersey, USA
Cogn Affect Behav Neurosci 10:298-315. 2010..We propose that the effect of context on P2 is consistent with the onset of context updating in the PFC. Subsequent components may be indicative of activation of task-relevant posterior regions and context maintenance... - Parsing executive processes: strategic vs. evaluative functions of the anterior cingulate cortexC S Carter
Department of Psychiatry, University of Pittsburgh, Western Psychiatric Institute and Clinics, 3811 O Hara Street, Pittsburgh, PA 15213, USA
Proc Natl Acad Sci U S A 97:1944-8. 2000..Instead, it suggests that the ACC serves an evaluative function, detecting cognitive states such as response competition, which may lead to poor performance, and representing the knowledge that strategic processes need to be engaged... - Independent component analysis for brain fMRI does not select for independenceI DAUBECHIES
Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
Proc Natl Acad Sci U S A 106:10415-22. 2009..The mathematical design of better analysis tools for brain fMRI should thus emphasize other mathematical characteristics than independence... - An fMRI investigation of emotional engagement in moral judgmentJ D Greene
Center for the Study of Brain, Mind, and Behavior, Department of Philosophy, 1879 Hall, Princeton University, Princeton, NJ 08544, USA
Science 293:2105-8. 2001..These results may shed light on some puzzling patterns in moral judgment observed by contemporary philosophers... - Sequential effects in two-choice reaction time tasks: decomposition and synthesis of mechanismsJuan Gao
Department of Mechanical and Aerospace Engineering and Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA
Neural Comput 21:2407-36. 2009..The results also suggest that practice speeds up all the mechanisms rather than adjusting their relative strengths... - The MATRICS Consensus Cognitive Battery, part 1: test selection, reliability, and validityKeith H Nuechterlein
Department of Psychology, UCLA Semel Institute for Neuroscience and Human Behavior, 300 Medical Plaza, Rm 2251, Los Angeles, CA 90095 6968, USA
Am J Psychiatry 165:203-13. 2008.... - Distinct and independent correlates of attention and awareness in a hemianopic patientAaron Schurger
Department of Psychology, Princeton University, Princeton, NJ, USA
Neuropsychologia 46:2189-97. 2008..The finding of a significant awareness-independent effect in the area of 40Hz implies that a stimulus-induced modulation of power in the canonical gamma band is not a sufficient condition for sensory awareness... - BOLD responses reflecting dopaminergic signals in the human ventral tegmental areaKimberlee D'Ardenne
Department of Chemistry, Princeton University, Princeton, NJ 08544, USA
Science 319:1264-7. 2008..When monetary gains and losses were used, VTA BOLD responses reflected positive reward prediction errors modulated by the probability of winning. We detected no significant VTA BOLD response to nonrewarding events... - Theta phase resetting and the error-related negativityNick Yeung
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania, USA
Psychophysiology 44:39-49. 2007..These findings suggest that the proposed analysis methods cannot provide unambiguous evidence that the ERN is generated by phase resetting of ongoing oscillations... - Time discounting for primary rewardsSamuel M McClure
Center for the Study of Brain, Mind, and Behavior and Department of Psychology, Princeton University, Princeton, New Jersey 08540, USA
J Neurosci 27:5796-804. 2007..We discuss implications of this finding for differences between primary and secondary rewards... - Regions of the MPFC differentially tuned to social and nonsocial affective evaluationLasana T Harris
Princeton University, Princeton, New Jersey, USA
Cogn Affect Behav Neurosci 7:309-16. 2007..Affective evaluation may be a general function of the MPFC, with some regions being tuned to more specific domains of information (e.g., social) than are others... - A neural network model of the Eriksen task: reduction, analysis, and data fittingYuan Sophie Liu
Department of Physics, Princeton University, Princeton, NJ 08544, USA
Neural Comput 20:345-73. 2008..We compare our results with numerical simulations of the full nonlinear model and with empirical data and show good fits to both with fewer parameters... - Rapid decision threshold modulation by reward rate in a neural networkPatrick Simen
Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
Neural Netw 19:1013-26. 2006..The model makes predictions regarding optimal performance and provides a benchmark against which actual performance can be compared, as well as testable predictions about the way in which reward rate may be encoded by neural mechanisms... - Acquisition of decision making criteria: reward rate ultimately beats accuracyFuat Balci
Princeton Neuroscience Institute, Princeton University, Green Hall, Princeton, NJ 08544, USA
Atten Percept Psychophys 73:640-57. 2011..The residual discrepancy between optimal and observed performance can be explained by an adaptive response to uncertainty in time estimation... - Explicit melioration by a neural diffusion modelPatrick Simen
Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA
Brain Res 1299:95-117. 2009..Results suggest that melioration and matching may derive from synapses that estimate reward rates by a process of leaky integration, and that link together the input and output stages of a two-stage stimulus-response mechanism... - Opposing BOLD responses to reciprocated and unreciprocated altruism in putative reward pathwaysJames K Rilling
Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
Neuroreport 15:2539-43. 2004..Our results are consistent with the hypothesis that mesencephalic dopamine projection sites carry information about errors in reward prediction that allow us to learn who can and cannot be trusted to reciprocate favors... - The neural correlates of theory of mind within interpersonal interactionsJames K Rilling
Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ 08544, USA
Neuroimage 22:1694-703. 2004..Although computer partners elicited activation in some of the same areas activated by human partners, most of these activations were stronger for human partners... - Reproducibility distinguishes conscious from nonconscious neural representationsAaron Schurger
Department of Psychology, Princeton University, Princeton, NJ 08540, USA
Science 327:97-9. 2010..This is not adequately explained by a difference in signal-to-noise ratio... - Dorsal anterior cingulate cortex shows fMRI response to internal and external error signalsClay B Holroyd
Department of Psychology, Green Hall, Princeton University, Princeton, New Jersey 08544, USA
Nat Neurosci 7:497-8. 2004.... - Simplified dynamics in a model of noradrenergic modulation of cognitive performanceMark S Gilzenrat
Center for the Study of Brain, Mind, and Behavior, Princeton University, NJ 08544, USA
Neural Netw 15:647-63. 2002..These results suggest a reverse sigmoidal relationship between false alarm rate and coherence, and a more complex, non-monotonic relationship between response time and coherence... - Context dependence of the event-related brain potential associated with reward and punishmentClay B Holroyd
Department of Psychology, Princeton University, Princeton, New Jersey 08540, USA
Psychophysiology 41:245-53. 2004..This result is discussed in terms of a recent theory that holds that the ERN reflects a reward prediction error signal associated with a neural system for reinforcement learning... - Placebo-induced changes in FMRI in the anticipation and experience of painTor D Wager
Department of Psychology, University of Michigan, 525 East University, Ann Arbor, MI 48109 1109, USA
Science 303:1162-7. 2004.... - Reward rate optimization in two-alternative decision making: empirical tests of theoretical predictionsPatrick Simen
Princeton Neuroscience Institute, Princeton University, USA
J Exp Psychol Hum Percept Perform 35:1865-97. 2009..We tested the resulting quantitative predictions regarding response time, accuracy, and response bias under these task manipulations and found that grouped data conformed well to the predictions of an optimally parameterized DDM... - Errors in reward prediction are reflected in the event-related brain potentialClay B Holroyd
Department of Psychology, Princeton University, NJ 08544, USA
Neuroreport 14:2481-4. 2003..Consistent with the theory, we found that larger ERNs were elicited by unexpected absences of reward... - Optimal performance in a countermanding saccade taskKongfatt Wong-Lin
Program in Applied and Computational Mathematics, Princeton University, Princeton, NJ 08544, USA
Brain Res 1318:178-87. 2010..We propose experiments to test these predictions regarding optimal behavior... - The neural bases of cognitive conflict and control in moral judgmentJoshua D Greene
Department of Psychology, Princeton University, Princeton, NJ 08544, USA
Neuron 44:389-400. 2004..We speculate that the controversy surrounding utilitarian moral philosophy reflects an underlying tension between competing subsystems in the brain... - Context-processing deficits in schizophrenia: diagnostic specificity, 4-week course, and relationships to clinical symptomsDeanna M Barch
Department of Psychology, St Louis, Missouri 63130 4899, USA
J Abnorm Psychol 112:132-43. 2003..However, context-processing deficits improved in the psychotic comparison group at 4 weeks but did not improve in patients with schizophrenia... - Phasic activation of monkey locus ceruleus neurons by simple decisions in a forced-choice taskEdwin C Clayton
Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Neurosci 24:9914-20. 2004..This role of the LC in regulating the behavioral outcome of decisional processes contrasts with more traditional views of LC responses as primarily related to sensory processes... - Generalized signaling for control: evidence from postconflict and posterror performance adjustmentsRaymond Y Cho
Department of Psychiatry, Western Psychiatric Institue and Clinic, University of Pittsburg, 3811 O Hara Street, Oxford 454, Pittsburg, PA 15213, USA
J Exp Psychol Hum Percept Perform 35:1161-77. 2009..The results showed that trial-to-trial adjustments exist for both direction-repeat and direction-switch trials, demonstrating that signaling for control adjustments can extend beyond the task context within which they arise... - Separate neural systems value immediate and delayed monetary rewardsSamuel M McClure
Department of Psychology and Center for the Study of Brain, Mind, and Behavior, Princeton University, Princeton, NJ 08544, USA
Science 306:503-7. 2004..Furthermore, the relative engagement of the two systems is directly associated with subjects' choices, with greater relative fronto-parietal activity when subjects choose longer term options... - Errors without conflict: implications for performance monitoring theories of anterior cingulate cortexVincent van Veen
Department of Psychology, University of Pittsburgh, PA, USA
Brain Cogn 56:267-76. 2004..These results question involvement of the ACC in the detection of errors per se when controlling for conflict... - Parameterization of connectionist modelsRafal Bogacz
Princeton University, Princeton, New Jersey, USA
Behav Res Methods Instrum Comput 36:732-41. 2004..The method has been implemented in Matlab, is fully documented, and is available for free download from the Psychonomic Society Web archive at www.psychonomic.org/archive/... - A mechanism for error detection in speeded response time tasksClay B Holroyd
Department of Psychology, Princeton University, NJ, USA
J Exp Psychol Gen 134:163-91. 2005..B. Holroyd & M. G. H. Coles, 2002). The model is used to simulate behavioral and event-related brain potential data in a speeded response time task, and the results of the simulation are compared with empirical data... - Prefrontal cortex and flexible cognitive control: rules without symbolsNicolas P Rougier
Department of Psychology, University of Colorado, 345 UCB, Boulder, CO 80309, USA
Proc Natl Acad Sci U S A 102:7338-43. 2005..The same model is shown to apply to benchmark PFC tasks (Stroop and Wisconsin card sorting), accurately simulating the behavior of neurologically intact and frontally damaged people... - Neuroeconomics: cross-currents in research on decision-makingAlan G Sanfey
Department of Psychology, University of Arizona, Tucson, AZ 85721, USA
Trends Cogn Sci 10:108-16. 2006..The integration of these disparate theoretical approaches and methodologies offers exciting potential for the construction of more accurate models of decision-making... - Prefrontal functioning during context processing in schizophrenia and major depression: an event-related fMRI studyAvram J Holmes
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
Schizophr Res 76:199-206. 2005..The imaging data replicate previous results in showing abnormal activity in the right middle frontal gyrus (BA9) in schizophrenia patients related to context processing... - Neural and behavioral substrates of mood and mood regulationRichard J Davidson
Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin 53706, USA
Biol Psychiatry 52:478-502. 2002..Training interdisciplinary clinical scientists who meaningfully draw upon both behavioral and neuroscientific literatures and methods is critically required for the realization of these goals... - The role of the locus coeruleus in mediating the attentional blink: a neurocomputational theorySander Nieuwenhuis
Department of Psychology, Princeton University, NJ, USA
J Exp Psychol Gen 134:291-307. 2005..Finally, the relationship between the authors' neurocomputational theory and existing cognitive theories of the attentional blink is discussed... - Context processing in older adults: evidence for a theory relating cognitive control to neurobiology in healthy agingT S Braver
Department of Psychology, Washington University, St Louis, Missouri 63130, USA
J Exp Psychol Gen 130:746-63. 2001..Older adults exhibited both performance decrements and, counterintuitively, performance improvements that are in close agreement with model predictions... - Conflict monitoring versus selection-for-action in anterior cingulate cortexM Botvinick
Department of Psychology, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Nature 402:179-81. 1999.... - Anterior cingulate cortex, conflict monitoring, and levels of processingV van Veen
Department of Psychology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Neuroimage 14:1302-8. 2001..These results suggest a highly specific contribution of the ACC to executive functions, through the detection of conflicts occurring at later or response-related levels of processing... - The physics of optimal decision making: a formal analysis of models of performance in two-alternative forced-choice tasksRafal Bogacz
Center for the Study of Brain, Mind and Behavior, Princeton University, Princeton, NJ, USA
Psychol Rev 113:700-65. 2006..They use these findings to address empirical data and make novel predictions about performance under optimality... - Automatic activation of the semantic network in schizophrenia: evidence from event-related brain potentialsRuth Condray
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
Biol Psychiatry 54:1134-48. 2003..Pharmacologic agents, such as haloperidol, might enhance automatic activation of the semantic network in this patient population, as indexed by the N400 component of the ERP... - Adaptive gain and the role of the locus coeruleus-norepinephrine system in optimal performanceGary Aston-Jones
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
J Comp Neurol 493:99-110. 2005..We propose that these prefrontal areas produce the above patterns of LC activity to optimize the utility of performance on both short and long time scales... - Is knowing always feeling?Alan G Sanfey
Department of Psychology, University of Arizona, Tuscon, AZ 85721, USA
Proc Natl Acad Sci U S A 101:16709-10. 2004 - Dynamics of attentional selection under conflict: toward a rational Bayesian accountAngela J Yu
Center for the Study of Brain, Mind, and Behavior, Princeton University, USA
J Exp Psychol Hum Percept Perform 35:700-17. 2009..The authors also consider how this conflict information might be disseminated and used to control processing... - An integrative theory of locus coeruleus-norepinephrine function: adaptive gain and optimal performanceGary Aston-Jones
Laboratory of Neuromodulation and Behavior, Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA
Annu Rev Neurosci 28:403-50. 2005..We propose that these frontal areas produce the above patterns of LC activity to optimize utility on both short and long timescales... - Detection of synchronized oscillations in the electroencephalogram: an evaluation of methodsNick Yeung
Department of Psychology, Princeton University, Princeton, New Jersey, USA
Psychophysiology 41:822-32. 2004..These findings suggest that proposed analysis methods may not effectively disambiguate competing views of ERP generation... - Category-specific cortical activity precedes retrieval during memory searchSean M Polyn
Department of Psychology, University of Pennsylvania, Philadelphia, PA 19104, USA
Science 310:1963-6. 2005..This result is consistent with the hypothesis that category-specific activity is cueing the memory system to retrieve studied items... - Functional imaging of decision conflictJean Baptiste Pochon
INSERM Avenir IFR70 and U610, Hopital Pitie Salpetriere, F 75103 Paris, France
J Neurosci 28:3468-73. 2008..Furthermore, we show that it does so for a complex decision task, one that requires the integration of beliefs and preferences and not just perceptual judgments... - Prefrontal cortex dysfunction mediates deficits in working memory and prepotent responding in schizophreniaWilliam M Perlstein
Department of Clinical and Health Psychology and the McKnight Brain Institute, University of Florida, Gainesville, 32610, USA
Biol Psychiatry 53:25-38. 2003..Findings are consistent with the operation of a single underlying PFC-mediated cognitive control mechanism and with physiologic dysfunction of the dorsolateral PFC in schizophrenic patients reflecting impairments in this mechanism... - A computational model of anterior cingulate function in speeded response tasks: effects of frequency, sequence, and conflictAndrew D Jones
Washington University, St. Louis, Missouri 63130, USA
Cogn Affect Behav Neurosci 2:300-17. 2002..The results indicate that the conflict-monitoring hypothesis, augmented by mechanisms for encoding stimulus history, can explain key phenomena associated with performance in sequential speeded response tasks... - COMT genotype influences prefrontal response to emotional distractionSonia J Bishop
MRC Wellcome Trust Behavioural and Clinical Neuroscience Institute, Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, England
Cogn Affect Behav Neurosci 6:62-70. 2006..These findings provide an initial step toward identifying genetic contributions to interindividual variability in recruitment of mechanisms that regulate affective processing... - Anterior cingulate conflict monitoring and adjustments in controlJohn G Kerns
Department of Psychological Sciences, University of Missouri-Columbia, Columbia, MO 65211, USA
Science 303:1023-6. 2004.... - Prefrontal cortex guides context-appropriate responding during language productionJohn G Kerns
Department of Psychological Sciences, University of Missouri-Columbia, 65211, USA
Neuron 43:283-91. 2004..Overall, as in other cognitive task domains, these results suggest that PFC context processing plays an important role in the control of language... - Cognitive load selectively interferes with utilitarian moral judgmentJoshua D Greene
Department of Psychology, Harvard University, 33 Kirkland St, Cambridge, MA 02138, United States
Cognition 107:1144-54. 2008..This interference effect provides direct evidence for the influence of controlled cognitive processes in moral judgment, and utilitarian moral judgment more specifically... - Computational roles for dopamine in behavioural controlP Read Montague
Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA
Nature 431:760-7. 2004..The application of such quantitative models has opened up new fields, ripe for attack by young synthesizers and theoreticians... - Conflict monitoring and anterior cingulate cortex: an updateMatthew M Botvinick
University of Pennsylvania, Center for Cognitive Neuroscience, 3720 Walnut Street, Philadelphia, PA 10104 6241, USA
Trends Cogn Sci 8:539-46. 2004..Recent research has also begun to shed light on the larger function of the ACC, suggesting some new possibilities concerning how conflict monitoring might fit into the cingulate's overall role in cognition and action... - Altering expectancy dampens neural response to aversive taste in primary taste cortexJack B Nitschke
Waisman Laboratory for Brain Imaging and Behavior, Waisman Center, Departments of Psychiatry and Psychology, University of Wisconsin, 1500 Highland Avenue, Madison, Wisconsin 53705 2274, USA
Nat Neurosci 9:435-42. 2006..In addition, the activation of the right insula and operculum tracked online ratings of the aversiveness for each taste. Such expectancy-driven modulation of primary sensory cortex may affect perceptions of external events... - Dissociating affective evaluation and social cognitive processes in the ventral medial prefrontal cortexWouter van den Bos
University of Amsterdam, Amsterdam, The Netherlands
Cogn Affect Behav Neurosci 7:337-46. 2007..These findings suggest that, within the vmPFC, the PACC subserves primarily an affective function, whereas in other regions social context can modulate affective responses... - Factors influencing Stroop performance in schizophreniaDeanna M Barch
Washington University, St Louis, MO 63130, USA
Neuropsychology 18:477-84. 2004.... - Cognitive neuroscience: decision amid uncertaintyJonathan D Cohen
Nature 436:471-2. 2005 - Decreased conflict- and error-related activity in the anterior cingulate cortex in subjects with schizophreniaJohn G Kerns
UC Davis Imaging Research Center, University of California-Davis, 4701 X Street, Sacramento, CA 95817, USA
Am J Psychiatry 162:1833-9. 2005..The current results suggest that impaired conflict monitoring by the anterior cingulate cortex might play an important role in contributing to cognitive control deficits in patients with schizophrenia... - NeuroeconomicsGeorge Loewenstein
Department of Social and Decision Sciences, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213, USA
Annu Rev Psychol 59:647-72. 2008..In addition to reviewing new economic models inspired by this research, we also discuss how neuroeconomics may influence future work in psychology...
Research Grants
- Functional MRI and Modeling Studies of Prefrontal CortexJonathan Cohen; Fiscal Year: 2007..abstract_text> ..
- Cognitive and Neural Mechanisms of Decision and ControlJonathan Cohen; Fiscal Year: 2007....
- Neural mechanisms and social influence in delay discounting and impulsive choiceJonathan Cohen; Fiscal Year: 2007....
- Mechanisms of Context Processing in SchizophreniaJonathan Cohen; Fiscal Year: 2009....
- NRSA Training Grant in Quantitative NeuroscienceJonathan Cohen; Fiscal Year: 2006....
- FUNCTIONAL MRI STUDIES OF PREFRONTAL CORTEXJonathan Cohen; Fiscal Year: 1999..A better understanding of PFC promises to provide important insights into the mechanisms underlying uniquely human cognitive abilities, such as problem solving and language, and their disturbance in diseases such as schizophrenia. ..
- MECHANISM OF CONTEXT PROCESSING IN SCHIZOPHRENIAJonathan Cohen; Fiscal Year: 2001....
- USABILITY AND INTEROPERABILITY OF NEUROIMAGING SOFTWAREJonathan Cohen; Fiscal Year: 2002..This Desktop will be written in Java and will use CORBA to manage the client/server interactions. ..
- Neural mechanisms and social influence in delay discounting and impulsive choiceJonathan D Cohen; Fiscal Year: 2010....