Rumela Chakrabarti

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. doi request reprint Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, NJ 08554, USA
    Stem Cells 30:1496-508. 2012
  2. pmc ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Cell Biol 16:1004-15, 1-13. 2014
  3. pmc Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    Nat Cell Biol 14:1212-22. 2012
  4. pmc MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors
    Liling Wan
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 26:92-105. 2014
  5. pmc Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity
    Rommel A Mathias
    Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, 3086, Australia
    Cell 159:1615-25. 2014
  6. doi request reprint Transplantable mouse tumor models of breast cancer metastasis
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Washington Road, LTL 255, Princeton, NJ, 08544, USA
    Methods Mol Biol 1267:367-80. 2015
  7. pmc Genome-wide search identifies Ccnd2 as a direct transcriptional target of Elf5 in mouse mammary gland
    Rosalba Escamilla-Hernandez
    Department of Biochemistry, State University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA
    BMC Mol Biol 11:68. 2010

Collaborators

  • Yibin Kang
  • Toni Ibrahim
  • Hao Wu
  • Dino Amadori
  • Qifeng Yang
  • Marc S Halfon
  • Liling Wan
  • Rommel A Mathias
  • Rosalba Escamilla-Hernandez
  • Salina Yuan
  • Bruce G Haffty
  • Roderick T Bronson
  • Min Yuan
  • Yuling Hua
  • Elizabeth A Rowland
  • Marina Chekmareva
  • Yong Wei
  • Heath A Smith
  • Xin Lu
  • Todd M Greco
  • Feng Guo
  • Minhong Shen
  • Thomas Shenk
  • Ileana M Cristea
  • Yongna Xing
  • Adam Oberstein
  • Mario Andres Blanco
  • Hanna G Budayeva
  • Kirsten Smalley
  • Qianqian Zhu
  • Michael J Buck
  • Satrajit Sinha
  • Rose Anne Romano
  • William Lai

Detail Information

Publications7

  1. doi request reprint Elf5 regulates mammary gland stem/progenitor cell fate by influencing notch signaling
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, NJ 08554, USA
    Stem Cells 30:1496-508. 2012
    ....
  2. pmc ΔNp63 promotes stem cell activity in mammary gland development and basal-like breast cancer by enhancing Fzd7 expression and Wnt signalling
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08544, USA
    Nat Cell Biol 16:1004-15, 1-13. 2014
    ..These findings establish ΔNp63 as a key regulator of stem cells in both normal and malignant mammary tissues and provide direct evidence that breast cancer TICs and normal MaSCs share common regulatory mechanisms. ..
  3. pmc Elf5 inhibits the epithelial-mesenchymal transition in mammary gland development and breast cancer metastasis by transcriptionally repressing Snail2
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Princeton, New Jersey 08540, USA
    Nat Cell Biol 14:1212-22. 2012
    ..These findings establish Elf5 not only as a key cell lineage regulator during normal mammary gland development, but also as a suppressor of EMT and metastasis in breast cancer...
  4. pmc MTDH-SND1 interaction is crucial for expansion and activity of tumor-initiating cells in diverse oncogene- and carcinogen-induced mammary tumors
    Liling Wan
    Department of Molecular Biology, Princeton University, Princeton, NJ 08544, USA
    Cancer Cell 26:92-105. 2014
    ..This functional significance of MTDH-SND1 interaction is further supported by clinical analysis of human breast cancer samples. ..
  5. pmc Sirtuin 4 is a lipoamidase regulating pyruvate dehydrogenase complex activity
    Rommel A Mathias
    Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA Department of Biochemistry, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, 3086, Australia
    Cell 159:1615-25. 2014
    ..Furthermore, metabolic flux switching via glutamine stimulation induces SIRT4 lipoamidase activity to inhibit PDH, highlighting SIRT4 as a guardian of cellular metabolism. ..
  6. doi request reprint Transplantable mouse tumor models of breast cancer metastasis
    Rumela Chakrabarti
    Department of Molecular Biology, Princeton University, Washington Road, LTL 255, Princeton, NJ, 08544, USA
    Methods Mol Biol 1267:367-80. 2015
    ..In this chapter, we describe transplantable xenograft and allograft methods to introduce human or mouse breast tumor cells into mice in order to generate spontaneous and experimental metastasis. ..
  7. pmc Genome-wide search identifies Ccnd2 as a direct transcriptional target of Elf5 in mouse mammary gland
    Rosalba Escamilla-Hernandez
    Department of Biochemistry, State University of New York at Buffalo, Center for Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA
    BMC Mol Biol 11:68. 2010
    ..To address this shortcoming, in this study we have performed ChIP-cloning experiments to identify the specific genomic segments that are occupied by Elf5 in pregnant mouse mammary glands...