Joshua S Bloom

Summary

Affiliation: Princeton University
Country: USA

Publications

  1. pmc Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays
    Joshua S Bloom
    Lewis Sigler Institute of Integrative Genomics, Princeton University, New Jersey, USA
    BMC Genomics 10:221. 2009
  2. pmc Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS
    Zia Khan
    Department of Computer Science, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 8:602. 2012
  3. doi request reprint Genetics of single-cell protein abundance variation in large yeast populations
    Frank W Albert
    1 Department of Human Genetics, University of California, Los Angeles, California 90095, USA 2 Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 506:494-7. 2014
  4. pmc Accurate proteome-wide protein quantification from high-resolution 15N mass spectra
    Zia Khan
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Washington Rd, Princeton, NJ 08544, USA
    Genome Biol 12:R122. 2011
  5. pmc A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays
    Zia Khan
    Department of Computer Science, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Bioinformatics 25:1609-16. 2009
  6. pmc Protein quantification across hundreds of experimental conditions
    Zia Khan
    Department of Computer Science, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA
    Proc Natl Acad Sci U S A 106:15544-8. 2009
  7. pmc A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology
    Erik C Andersen
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 10:e1004156. 2014
  8. pmc Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown
    Mariana D Plazas-Mayorca
    Department of Chemistry, Princeton University, Princeton, NJ 08540, USA
    Mol Biosyst 6:1719-29. 2010
  9. pmc Finding the sources of missing heritability in a yeast cross
    Joshua S Bloom
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 494:234-7. 2013
  10. pmc Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity
    Erik C Andersen
    Lewis Sigler Institute for Integrative Genomics, Princeton University, New Jersey, USA
    Nat Genet 44:285-90. 2012

Detail Information

Publications10

  1. pmc Measuring differential gene expression by short read sequencing: quantitative comparison to 2-channel gene expression microarrays
    Joshua S Bloom
    Lewis Sigler Institute of Integrative Genomics, Princeton University, New Jersey, USA
    BMC Genomics 10:221. 2009
    ..High-throughput cDNA synthesis and sequencing of poly(A)-enriched RNA is rapidly emerging as a technology competing to replace microarrays as a quantitative platform for measuring gene expression...
  2. pmc Quantitative measurement of allele-specific protein expression in a diploid yeast hybrid by LC-MS
    Zia Khan
    Department of Computer Science, Princeton University, Princeton, NJ 08544, USA
    Mol Syst Biol 8:602. 2012
    ..Our results provide the first analysis of the relative contribution of cis-acting and trans-acting regulatory differences to protein expression divergence between yeast species...
  3. doi request reprint Genetics of single-cell protein abundance variation in large yeast populations
    Frank W Albert
    1 Department of Human Genetics, University of California, Los Angeles, California 90095, USA 2 Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08544, USA
    Nature 506:494-7. 2014
    ..The variants that underlie these hotspots have profound effects on the gene regulatory network and provide insights into genetic variation in cell physiology between yeast strains. ..
  4. pmc Accurate proteome-wide protein quantification from high-resolution 15N mass spectra
    Zia Khan
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Washington Rd, Princeton, NJ 08544, USA
    Genome Biol 12:R122. 2011
    ..Application of this method to an Escherichia coli growth transition reveals significant improvement in quantification accuracy over previous methods...
  5. pmc A practical algorithm for finding maximal exact matches in large sequence datasets using sparse suffix arrays
    Zia Khan
    Department of Computer Science, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA
    Bioinformatics 25:1609-16. 2009
    ....
  6. pmc Protein quantification across hundreds of experimental conditions
    Zia Khan
    Department of Computer Science, Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08540, USA
    Proc Natl Acad Sci U S A 106:15544-8. 2009
    ..We demonstrate the scalability of these techniques by applying them to a large dataset that comprises a total of 472 experimental conditions and replicates...
  7. pmc A variant in the neuropeptide receptor npr-1 is a major determinant of Caenorhabditis elegans growth and physiology
    Erik C Andersen
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey, United States of America
    PLoS Genet 10:e1004156. 2014
    ..These results suggest that variation in npr-1 has broad pleiotropic effects mediated by altered exposure to bacterial food. ..
  8. pmc Quantitative proteomics reveals direct and indirect alterations in the histone code following methyltransferase knockdown
    Mariana D Plazas-Mayorca
    Department of Chemistry, Princeton University, Princeton, NJ 08540, USA
    Mol Biosyst 6:1719-29. 2010
    ..Our results provide new insights into the intra- and inter- histone cross-regulation of histone K9 methylation and its potential downstream gene targets...
  9. pmc Finding the sources of missing heritability in a yeast cross
    Joshua S Bloom
    Lewis Sigler Institute for Integrative Genomics, Princeton University, Princeton, New Jersey 08540, USA
    Nature 494:234-7. 2013
    ..These results substantially advance our understanding of the missing heritability problem and have important implications for future studies of complex and quantitative traits...
  10. pmc Chromosome-scale selective sweeps shape Caenorhabditis elegans genomic diversity
    Erik C Andersen
    Lewis Sigler Institute for Integrative Genomics, Princeton University, New Jersey, USA
    Nat Genet 44:285-90. 2012
    ..These sweeps, which we hypothesize to be a result of human activity, have drastically reshaped the global C. elegans population in the recent past...