B D Levine

Summary

Affiliation: Presbyterian Hospital of Dallas
Country: USA

Publications

  1. pmc The effect of age-related differences in body size and composition on cardiovascular determinants of VO2max
    Graeme Carrick-Ranson
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Gerontol A Biol Sci Med Sci 68:608-16. 2013
  2. doi request reprint The effect of exercise training on left ventricular relaxation and diastolic suction at rest and during orthostatic stress after bed rest
    Graeme Carrick-Ranson
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    Exp Physiol 98:501-13. 2013
  3. pmc Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure
    Naoki Fujimoto
    University of Texas Southwestern Medical Center at Dallas
    Circulation 127:55-62. 2013
  4. pmc Short-term exercise training improves the cardiovascular response to exercise in the postural orthostatic tachycardia syndrome
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 590:3495-505. 2012
  5. pmc Cardiac output and sympathetic vasoconstrictor responses during upright tilt to presyncope in healthy humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    J Physiol 590:1839-48. 2012
  6. pmc Effect of ageing on left ventricular compliance and distensibility in healthy sedentary humans
    Naoki Fujimoto
    The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Physiol 590:1871-80. 2012
  7. pmc .VO2max: what do we know, and what do we still need to know?
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    J Physiol 586:25-34. 2008
  8. ncbi request reprint Intermittent hypoxic training: fact and fancy
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas University of Texas Southwestern Medical Center at Dallas, 75231, USA
    High Alt Med Biol 3:177-93. 2002
  9. pmc Neural and nonneural mechanisms for sex differences in elderly hypertension: can exercise training help?
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Hypertension 52:787-94. 2008
  10. ncbi request reprint Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center Dallas, Texas, USA
    J Appl Physiol 99:2053-5. 2005

Detail Information

Publications107 found, 100 shown here

  1. pmc The effect of age-related differences in body size and composition on cardiovascular determinants of VO2max
    Graeme Carrick-Ranson
    University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Gerontol A Biol Sci Med Sci 68:608-16. 2013
    ..It is also unclear to what extent scaling size-related cardiovascular determinants of VO2max affects the interpretation of age-related differences...
  2. doi request reprint The effect of exercise training on left ventricular relaxation and diastolic suction at rest and during orthostatic stress after bed rest
    Graeme Carrick-Ranson
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    Exp Physiol 98:501-13. 2013
    ..Therefore, the reduction in upright SV after HDBR is more influenced by changes in LV loading conditions, namely left atrial pressure in the setting of LV remodelling, rather than ventricular relaxation and diastolic suction...
  3. pmc Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure
    Naoki Fujimoto
    University of Texas Southwestern Medical Center at Dallas
    Circulation 127:55-62. 2013
    ..However, the normal hemodynamic response to a volume challenge and how age and sex affect this relationship remain unknown...
  4. pmc Short-term exercise training improves the cardiovascular response to exercise in the postural orthostatic tachycardia syndrome
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 590:3495-505. 2012
    ..023). There were no changes in any Doppler index after training. These results suggest that short-term exercise training improves physical fitness and cardiovascular responses during exercise in patients with POTS...
  5. pmc Cardiac output and sympathetic vasoconstrictor responses during upright tilt to presyncope in healthy humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    J Physiol 590:1839-48. 2012
    ..However, an intrinsic impairment of vasomotor responsiveness and sympathetic baroreflex function is not the cause of neurally mediated (pre)syncope in this population...
  6. pmc Effect of ageing on left ventricular compliance and distensibility in healthy sedentary humans
    Naoki Fujimoto
    The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Physiol 590:1871-80. 2012
    ..Thereafter, this LV stiffening is followed by LV volume contraction and remodelling after the age of 65...
  7. pmc .VO2max: what do we know, and what do we still need to know?
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    J Physiol 586:25-34. 2008
    ..The magnitude and mechanisms of cardiac phenotype plasticity remain uncertain and probably involve underlying genetic factors, as well as the length, duration, type, intensity and age of initiation of the training stimulus...
  8. ncbi request reprint Intermittent hypoxic training: fact and fancy
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas University of Texas Southwestern Medical Center at Dallas, 75231, USA
    High Alt Med Biol 3:177-93. 2002
    ....
  9. pmc Neural and nonneural mechanisms for sex differences in elderly hypertension: can exercise training help?
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Hypertension 52:787-94. 2008
  10. ncbi request reprint Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center Dallas, Texas, USA
    J Appl Physiol 99:2053-5. 2005
  11. ncbi request reprint Dose-response of altitude training: how much altitude is enough?
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, Dallas, TX 75231, USA
    Adv Exp Med Biol 588:233-47. 2006
    ....
  12. ncbi request reprint Effect of altitude on football performance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, Texas 75231, USA
    Scand J Med Sci Sports 18:76-84. 2008
    ....
  13. pmc Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231, USA
    J Physiol 538:331-40. 2002
    ..We conclude that after 16 days of spaceflight, muscle sympathetic nerve responses to upright tilt are normal...
  14. ncbi request reprint A 30-year follow-up of the Dallas Bedrest and Training Study: II. Effect of age on cardiovascular adaptation to exercise training
    D K McGuire
    Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 104:1358-66. 2001
    ..4 versus 21.7 L/min); submaximal heart rates also declined to a similar degree. Maximal AVDO(2) increased by 10% (13.8 versus 15.2 vol%) and accounted for the entire improvement of aerobic power associated with training...
  15. pmc Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 544:653-64. 2002
    ..We conclude that modulation of muscle sympathetic neural outflow by muscle metaboreceptors and skin nociceptors is preserved during short duration spaceflight...
  16. ncbi request reprint Effects of spaceflight on human calf hemodynamics
    D E Watenpaugh
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Appl Physiol 90:1552-8. 2001
    ..No calf hemodynamic result exhibited obvious mechanistic implications for postflight orthostatic intolerance...
  17. ncbi request reprint Vasoconstrictor reserve and sympathetic neural control of orthostasis
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, Dallas, Tex 75231, USA
    Circulation 110:2931-7. 2004
    ..We tested the hypothesis that individual variability in orthostatic tolerance is dependent on the degree of neural and vasomotor reserve available for vasoconstriction...
  18. ncbi request reprint Persistent sympathetic activation during chronic antihypertensive therapy: a potential mechanism for long term morbidity?
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    Hypertension 45:513-21. 2005
    ....
  19. ncbi request reprint The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, USA
    Adv Exp Med Biol 502:75-88. 2001
    ....
  20. ncbi request reprint Cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 291:H2142-51. 2006
    ..A cascade model of ventricular-arterial coupling with the arterial-cardiac baroreflex contributes to the genesis of cardiovascular variability at the respiratory frequency...
  21. ncbi request reprint A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise
    D K McGuire
    Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 104:1350-7. 2001
    ..Our study objective was to assess the effect of a 30-year interval on body composition and cardiovascular response to acute exercise in 5 healthy subjects originally evaluated in 1966...
  22. pmc Vasomotor sympathetic neural control is maintained during sustained upright posture in humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, TX 75231, USA
    J Physiol 577:679-87. 2006
    ..e. 45 min) orthostasis without obvious changes in vasomotor sympathetic neural control...
  23. ncbi request reprint Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: how much training for what benefit?
    Ken Ichi Iwasaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, and University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75231, USA
    J Appl Physiol (1985) 95:1575-83. 2003
    ....
  24. ncbi request reprint "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas 75231, Dallas, Texas 75235, USA
    J Appl Physiol (1985) 83:102-12. 1997
    ....
  25. ncbi request reprint Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Tex 75321, USA
    Circulation 96:517-25. 1997
    ..We hypothesized that this large fall in SV is due to a change in cardiac mechanics...
  26. pmc Evidence for unloading arterial baroreceptors during low levels of lower body negative pressure in humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, Texas, USA
    Am J Physiol Heart Circ Physiol 296:H480-8. 2009
    ..e., -10 and -15 mmHg) of LBNP in humans. Thus "selective" unloading of cardiopulmonary baroreceptors cannot be presumed to occur during these levels of mild LBNP...
  27. ncbi request reprint Cardiac atrophy after bed rest and spaceflight
    M A Perhonen
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA
    J Appl Physiol 91:645-53. 2001
    ..We suggest that cardiac atrophy is due to a physiological adaptation to reduced myocardial load and work in real or simulated microgravity and demonstrates the plasticity of cardiac muscle under different loading conditions...
  28. ncbi request reprint Effect of aging and physical activity on left ventricular compliance
    Armin Arbab-Zadeh
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, and University of Texas Southwestern Medical Center, Dallas, Tex 75231, USA
    Circulation 110:1799-805. 2004
    ..However, whether this change is an inevitable consequence of senescence or rather secondary to reduced physical activity is unknown...
  29. pmc 'Dynamic' Starling mechanism: effects of ageing and physical fitness on ventricular-arterial coupling
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    J Physiol 586:1951-62. 2008
    ..Life-long daily exercise training may minimize this impairment, although the effect may be limited particularly when started later in life...
  30. ncbi request reprint Effects of gender and hypovolemia on sympathetic neural responses to orthostatic stress
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, TX 75231, USA
    Am J Physiol Regul Integr Comp Physiol 289:R109-16. 2005
    ....
  31. ncbi request reprint Performance of runners and swimmers after four weeks of intermittent hypobaric hypoxic exposure plus sea level training
    Ferran A Rodríguez
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Dallas, TX 75231, USA
    J Appl Physiol 103:1523-35. 2007
    ..Whether there are potential benefits of this regimen for specific sports or training/tapering strategies may require further study...
  32. ncbi request reprint Nitric oxide synthase inhibition does not affect regulation of muscle sympathetic nerve activity during head-up tilt
    Jian Cui
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 285:H2105-10. 2003
    ..These results suggest that systemic inhibition of NO synthase with L-NMMA does not affect the regulation of sympathetic outflow and vascular resistance during head-up tilt in humans...
  33. ncbi request reprint Dose-response relationship of endurance training for autonomic circulatory control in healthy seniors
    Kazunobu Okazaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    J Appl Physiol 99:1041-9. 2005
    ..Seniors retain a similar degree of "trainability" as young subjects for cardiac autonomic function to dynamic exercise...
  34. pmc A forty-year follow-up of the Dallas Bed Rest and Training study: the effect of age on the cardiovascular response to exercise in men
    Jonathan M McGavock
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX 75231, USA
    J Gerontol A Biol Sci Med Sci 64:293-9. 2009
    ..The aim of the present study was to reexamine these same men 40 years following the original assessments...
  35. pmc Human cerebral autoregulation before, during and after spaceflight
    Ken Ichi Iwasaki
    Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 579:799-810. 2007
    ..We conclude that human cerebral autoregulation is preserved, and possibly even improved, by short-duration spaceflight...
  36. ncbi request reprint Effect of high-intensity hypoxic training on sea-level swimming performances
    M J Truijens
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center at Dallas, 75231, USA
    J Appl Physiol 94:733-43. 2003
    ..58). We conclude that 5 wk of high-intensity training in a flume improves sea-level swimming performances and Vo(2 max) in well-trained swimmers, with no additive effect of hypoxic training...
  37. ncbi request reprint Effects of whole body heating on dynamic baroreflex regulation of heart rate in humans
    C G Crandall
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231, USA
    Am J Physiol Heart Circ Physiol 279:H2486-92. 2000
    ..Reduced vagal baroreflex regulation of HR may contribute to reduced orthostatic tolerance known to occur in humans during heat stress...
  38. ncbi request reprint Effect of increasing central venous pressure during passive heating on skin blood flow
    C G Crandall
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231, Texas, USA
    J Appl Physiol (1985) 86:605-10. 1999
    ..05). These data suggest that cardiopulmonary baroreceptor unloading during passive heating may attenuate the elevation in SkBF in humans, whereas loading cardiopulmonary baroreceptors in normothermia has no effect on SkBF...
  39. ncbi request reprint Effect of high-altitude exposure in the elderly: the Tenth Mountain Division study
    B D Levine
    The Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and Division of Cardiology, University of Texas Southwestern Medical Center at Dallas, USA
    Circulation 96:1224-32. 1997
    ..We hypothesized that the elderly would exhibit an impaired functional capacity at altitude, with increased myocardial ischemia compared with sea level (SL)...
  40. ncbi request reprint Deterioration of left ventricular chamber performance after bed rest : "cardiovascular deconditioning" or hypovolemia?
    M A Perhonen
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital and University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Circulation 103:1851-7. 2001
    ..We studied whether the reduction in SV is due to a specific adaptation of the heart to head-down tilt bed rest (HDTBR) or acute hypovolemia alone...
  41. doi request reprint Comments on Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Autonomic control of the cerebral circulation is most important for dynamic cerebral autoregulation
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, UT Southwestern, TX, USA
    J Appl Physiol 105:1369-73. 2008
  42. pmc Cardiac origins of the postural orthostatic tachycardia syndrome
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas 75231, USA
    J Am Coll Cardiol 55:2858-68. 2010
    ..The purpose of this study was to test the hypothesis that a small heart coupled with reduced blood volume contributes to the postural orthostatic tachycardia syndrome (POTS) and that exercise training improves this syndrome...
  43. ncbi request reprint Hemodynamics of orthostatic intolerance: implications for gender differences
    Qi Fu
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 286:H449-57. 2004
    ..Thus cardiac mechanics and Frank-Starling relationship may be important mechanisms underlying the gender difference in orthostatic tolerance...
  44. ncbi request reprint Cerebral hemodynamics after short- and long-term reduction in blood pressure in mild and moderate hypertension
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, TX 75231, USA
    Hypertension 49:1149-55. 2007
    ....
  45. ncbi request reprint Intermittent hypobaric hypoxia exposure does not cause sustained alterations in autonomic control of blood pressure in young athletes
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1977-84. 2007
    ..In contrast to animal studies, we found no secondary evidence for sustained physiologically significant sympathoexcitation in this model...
  46. ncbi request reprint Cardiac atrophy in women following bed rest
    Todd A Dorfman
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    J Appl Physiol 103:8-16. 2007
    ..However, exercise training and, to a lesser extent, protein supplementation may be potential countermeasures to the cardiac atrophy associated with chronic unloading conditions such as in spaceflight and prolonged bed rest...
  47. pmc Cardiovascular effects of 1 year of progressive and vigorous exercise training in previously sedentary individuals older than 65 years of age
    Naoki Fujimoto
    Institute for Exercise and Environmental Medicine, Dallas, TX 75231, USA
    Circulation 122:1797-805. 2010
    ..However, it is unknown whether exercise training started later in life can reverse the effects of sedentary behavior on the heart...
  48. pmc Menstrual cycle effects on sympathetic neural responses to upright tilt
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    J Physiol 587:2019-31. 2009
    ..Thus, other factors rather than sympathetic baroreflex control mechanisms contribute to sex differences in orthostatic tolerance in young humans...
  49. pmc Dynamic pressure-flow relationship of the cerebral circulation during acute increase in arterial pressure
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    J Physiol 587:2567-77. 2009
    ..Thus, oscillations in CBFV are modulated not only by dynamic autoregulation, but also by changes in steady-state cerebrovascular resistance and/or vascular compliance...
  50. pmc Arterial-cardiac baroreflex function: insights from repeated squat-stand maneuvers
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center, Dallas, TX 75231, USA
    Am J Physiol Regul Integr Comp Physiol 297:R116-23. 2009
    ..Furthermore, baroreflex function can be assessed using the transfer function method during large perturbations in arterial pressure...
  51. pmc Autonomic circulatory control during pregnancy in humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Semin Reprod Med 27:330-7. 2009
    ....
  52. pmc Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, and University of Texas Southwestern Medical Center at Dallas, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    J Appl Physiol (1985) 108:1177-86. 2010
    ..This maintenance of orthostatic tolerance was achieved by neither exercise nor dextran infusion alone. Cardiac atrophy and hypovolemia are likely to contribute independently to orthostatic intolerance after bed rest...
  53. pmc Biological aortic age derived from the arterial pressure waveform
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, Dallas, Texas 75231, USA
    J Appl Physiol (1985) 110:981-7. 2011
    ....
  54. ncbi request reprint Autonomic ganglionic blockade does not prevent reduction in cerebral blood flow velocity during orthostasis in humans
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    Stroke 38:1238-44. 2007
    ..This study tested the hypothesis that sympathetic activation causes cerebral vasoconstriction leading to reductions in CBF during lower body negative pressure (LBNP)...
  55. ncbi request reprint Effect of skin surface cooling on central venous pressure during orthostatic challenge
    Jian Cui
    Inst for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 289:H2429-33. 2005
    ..These data indicate that skin surface cooling induced an upward shift in CVP throughout LBNP, which may be a key factor for preserving preload, stroke volume, and blood pressure and improving orthostatic tolerance...
  56. ncbi request reprint Inhibition of nitric oxide synthase does not alter dynamic cerebral autoregulation in humans
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231, USA
    Am J Physiol Heart Circ Physiol 286:H863-9. 2004
    ..These data suggest that inhibition of tonic production of NO does not appear to alter dynamic cerebral autoregulation in humans...
  57. ncbi request reprint Cerebral hemodynamics during the Valsalva maneuver: insights from ganglionic blockade
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and University of Texas Southwestern Medical Center, Dallas, Tex 75231, USA
    Stroke 35:843-7. 2004
    ..The aim of this study was to differentiate the mechanical effects of the Valsalva maneuver (VM) from the effects of changes in autonomic neural activity on cerebral hemodynamics in humans...
  58. pmc Menstrual cycle affects renal-adrenal and hemodynamic responses during prolonged standing in the postural orthostatic tachycardia syndrome
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Tex 75231, USA
    Hypertension 56:82-90. 2010
    ..The high estrogen and progesterone in the MLP are associated with greater increases in renal-adrenal hormones and presumably more volume retention, which improve late-standing tolerance in these patients...
  59. pmc White matter integrity in physically fit older adults
    B Y Tseng
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital, Dallas, TX, USA
    Neuroimage 82:510-6. 2013
    ..This study examined brain WM integrity in Masters athletes who have engaged in life-long aerobic exercise training. We tested the hypothesis that life-long aerobic training is associated with improved brain WM integrity in older adults...
  60. ncbi request reprint Determinants of erythropoietin release in response to short-term hypobaric hypoxia
    Ri Li Ge
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75231, USA
    J Appl Physiol 92:2361-7. 2002
    ....
  61. doi request reprint Altitude training considerations for the winter sport athlete
    Robert F Chapman
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    Exp Physiol 95:411-21. 2010
    ..For competitions at sea level, the 'live high-train low' model of altitude training can help athletes in endurance events to maximize performance...
  62. ncbi request reprint Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure
    Kazunobu Okazaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Suite 435, Dallas, Texas 75231, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1354-9. 2005
    ..Finally, from both techniques, we calculated that during venous congestion induced by limb dependency (calf), approximately 45% of the nonbaroreflex vasoconstriction is induced by the VAR and approximately 55% by the myogenic reflex...
  63. ncbi request reprint Prolonged head-down tilt exposure reduces maximal cutaneous vasodilator and sweating capacity in humans
    C G Crandall
    Institute for Exercise and Environmental Medicine at Presbyterian Hospital of Dallas, Dallas, Texas 75231, USA
    J Appl Physiol 94:2330-6. 2003
    ..These data suggest that 14 days of simulated microgravity exposure, using the HDT bed rest model, reduces cutaneous vasodilator and sweating capacity, whereas aerobic exercise training during HDT bed rest preserves these responses...
  64. ncbi request reprint Carotid sinus "irritability" rather than hypersensitivity: a new name for an old syndrome?
    C R Cole
    The Institute of Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA
    Clin Auton Res 11:109-13. 2001
    ....
  65. ncbi request reprint Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity
    Megan N Hawkins
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    Med Sci Sports Exerc 39:103-7. 2007
    ..This concept has recently been disputed because of the lack of published data reporting an unequivocal plateau in .VO2 during incremental exercise...
  66. ncbi request reprint Exercise throughout 6 degrees head-down tilt bed rest preserves thermoregulatory responses
    Manabu Shibasaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, Texas 75231, USA
    J Appl Physiol 95:1817-23. 2003
    ..These data suggest that dynamic exercise during this short period of HDT bed rest preserves thermoregulatory responses...
  67. pmc The effects of aging and physical activity on Doppler measures of diastolic function
    Anand Prasad
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital and University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 99:1629-36. 2007
    ....
  68. ncbi request reprint Ventilatory responses to exercise and hypercapnia following 18 days of head-down rest
    Helen E Wood
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center Dallas, Dallas, TX 75231, USA
    Aviat Space Environ Med 80:395-9. 2009
    ..Based on limited previous studies, we hypothesized that the ventilatory response to exercise would be increased, while the HCVR would be decreased after HDR...
  69. ncbi request reprint Coronary artery calcium score and coronary heart disease events in a large cohort of asymptomatic men and women
    Michael J LaMonte
    Centers for Integrated Health Research, The Cooper Institute, Dallas, TX 75230, USA
    Am J Epidemiol 162:421-9. 2005
    ..These findings show that CAC is associated with an increased risk of CHD events in asymptomatic women and men...
  70. doi request reprint Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting
    Todd A Dorfman
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    J Appl Physiol (1985) 104:1037-44. 2008
    ..We conclude that diastolic untwisting is impaired following sedentary bed rest. However, exercise training in bed can prevent the physiological cardiac remodeling associated with bed rest and preserve or even enhance diastolic suction...
  71. pmc Characterization of static and dynamic left ventricular diastolic function in patients with heart failure with a preserved ejection fraction
    Anand Prasad
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Dallas, Dallas, Tex 75231, USA
    Circ Heart Fail 3:617-26. 2010
    ....
  72. ncbi request reprint Cardiovascular response to exercise in women
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, USA
    Med Sci Sports Exerc 37:1433-5. 2005
  73. pmc Effects of pericardial constraint and ventricular interaction on left ventricular hemodynamics in the unloaded heart
    Naoki Fujimoto
    Institute for Exercise and Environmental Medicine, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 300:H1688-95. 2011
    ..These results suggest that the pericardium constrains LV filling during LBNP release, enough to cause a small but significant drop of SV, even at low cardiac filling pressure in healthy humans...
  74. pmc Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, Dallas, TX 75231, USA
    J Appl Physiol (1985) 110:964-71. 2011
    ....
  75. pmc Cardiac systolic and diastolic function during whole body heat stress
    R Matthew Brothers
    Presbyterian Hospital of Dallas, Institute of Exercise and Environmental Medicine, 7232 Greenville Ave, Ste 435, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 296:H1150-6. 2009
    ..Together these data support previous findings, which used the less precise measure of ejection fraction, that heat stress improves indexes of systolic function, while diastolic function is maintained...
  76. pmc The relationship of right- and left-sided filling pressures in patients with heart failure and a preserved ejection fraction
    Mark H Drazner
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex 75390 9047, USA
    Circ Heart Fail 3:202-6. 2010
    ..Although right-sided filling pressures often mirror left-sided filling pressures in systolic heart failure, it is not known whether a similar relationship exists in heart failure with preserved ejection fraction...
  77. ncbi request reprint Comparison of coronary artery calcium detected by electron beam tomography in patients with to those without symptomatic coronary heart disease
    Yiling J Cheng
    The Cooper Institute, Dallas, Texas, USA
    Am J Cardiol 92:498-503. 2003
    ..These observations support the potential of EBT as a sensitive test for detection of CHD...
  78. ncbi request reprint Effects of heat stress on thermoregulatory responses in congestive heart failure patients
    Jian Cui
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Circulation 112:2286-92. 2005
    ..However, thermoregulatory function during a controlled heat stress challenge in patients with CHF has not been studied...
  79. ncbi request reprint Obesity: associations with acute mountain sickness
    Ge Ri-Li
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA
    Ann Intern Med 139:253-7. 2003
    ..Although few retrospective studies of high altitude have reported that obesity might be associated with the development of acute mountain sickness (AMS), this association has not been studied prospectively...
  80. ncbi request reprint Abnormalities of Doppler measures of diastolic function in the healthy elderly are not related to alterations of left atrial pressure
    Anand Prasad
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital and the University of Texas Southwestern Medical Center at Dallas, TX 75231, USA
    Circulation 111:1499-503. 2005
    ..We sought to explore this issue directly by performing a detailed analysis of the pulmonary capillary wedge pressure waveform obtained by right-heart catheterization during 5 different loading conditions...
  81. ncbi request reprint Women have higher left ventricular ejection fractions than men independent of differences in left ventricular volume: the Dallas Heart Study
    Anne K Chung
    Donald W Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 113:1597-604. 2006
    ....
  82. pmc Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre
    James F Cox
    Department of Medicine and Physiology, Hunter Holmes McGuire Veterans Affairs Medical Center and Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia, USA 23249
    J Physiol 538:309-20. 2002
    ..This and earlier research suggest that exposure of healthy humans to microgravity augments arterial pressure and sympathetic responses to Valsalva straining and differentially reduces vagal, but not sympathetic baroreflex gain...
  83. pmc Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space
    Andrew C Ertl
    Vanderbilt University Medical Center, Nashville, TN, USA
    J Physiol 538:321-9. 2002
    ..Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels...
  84. ncbi request reprint Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect?
    James A Pawelczyk
    Noll Physiological Research Center and Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    J Appl Physiol (1985) 92:2105-13. 2002
    ..The relatively greater response to alpha1-adrenergic-receptor stimulation in the calf may represent an adaptive mechanism that limits blood pooling and capillary filtration in the legs during standing...
  85. ncbi request reprint Effects of 14 days of head-down tilt bed rest on cutaneous vasoconstrictor responses in humans
    Thad E Wilson
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    J Appl Physiol 94:2113-8. 2003
    ..It remains unclear whether attenuated venoarteriolar responses in the lower limbs contribute to reduced orthostatic tolerance after bed rest and spaceflight...
  86. pmc Mechanism of blood pressure and R-R variability: insights from ganglion blockade in humans
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    J Physiol 543:337-48. 2002
    ....
  87. ncbi request reprint Autonomic neural control of dynamic cerebral autoregulation in humans
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and The University of Texas Southwestern Medical Center at Dallas, Tex 75231, USA
    Circulation 106:1814-20. 2002
    ..The purpose of the present study was to determine the role of autonomic neural control of dynamic cerebral autoregulation in humans...
  88. ncbi request reprint Effect of hypoxic "dose" on physiological responses and sea-level performance
    Randall L Wilber
    Athlete Performance Laboratory, United States Olympic Committee, Colorado Springs, CO 80909, USA
    Med Sci Sports Exerc 39:1590-9. 2007
    ..d(-1)...
  89. ncbi request reprint Relationship among diastolic intraventricular pressure gradients, relaxation, and preload: impact of age and fitness
    Zoran B Popovic
    Cardiovascular Imaging Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 290:H1454-9. 2006
    ..The ability to regulate IVPGs during changes in preload is impaired with aging. Preserving ventricular compliance during aging by lifelong exercise training does not prevent this impairment...
  90. ncbi request reprint Hypertension and antihypertensive therapy in elderly women: how much do we really know?
    Qi Fu
    Hypertension 47:323-4. 2006
  91. ncbi request reprint Endothelin and aged blood vessels: one more reason to get off the couch?
    Dick H J Thijssen
    Hypertension 50:292-3. 2007
  92. ncbi request reprint Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin
    Thad E Wilson
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 289:H385-91. 2005
    ..Conversely, these data suggest that nonglabrous skin has diminished dynamic autoregulatory capabilities...
  93. ncbi request reprint The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners
    Martin J Truijens
    Faculty of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    J Appl Physiol (1985) 104:328-37. 2008
    ..No differences in submaximal HR, [La-], Ve, or velocity at V(.-)o2(max) were found between groups. It is concluded that 4 wk of intermittent hypobaric hypoxia did not improve submaximal economy in this group of well-trained athletes...
  94. ncbi request reprint Reduced baroreflex control of heart period after bed rest is normalized by acute plasma volume restoration
    Ken Ichi Iwasaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    Am J Physiol Regul Integr Comp Physiol 287:R1256-62. 2004
    ....
  95. ncbi request reprint Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4,000-5,500 m)
    Christopher J Gore
    Australian Institute of Sport, Canberra, Australia
    J Appl Physiol (1985) 101:1386-93. 2006
    ....
  96. ncbi request reprint Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners
    Colleen G Julian
    Sports Medicine Institute International, Palo Alto, California 94300, USA
    J Appl Physiol 96:1800-7. 2004
    ..Four weeks of a 5:5-min normobaric hypoxia exposure at rest for 70 min, 5 days/wk, is not a sufficient stimulus to elicit improved performance or change the normal level of erythropoiesis in highly trained runners...
  97. ncbi request reprint Cerebral hemodynamics during orthostatic stress assessed by nonlinear modeling
    Georgios D Mitsis
    Department of Biomedical Engineering, University of Southern California, Los Angeles, USA
    J Appl Physiol (1985) 101:354-66. 2006
    ....
  98. ncbi request reprint Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing
    Jurgen A H R Claassen
    Department of Geriatric Medicine, Radbound University Nijmegen Medical Center, The Netherlands
    J Appl Physiol 102:870-7. 2007
    ..Furthermore, quantification of the CVCi-Pet(CO(2)) relationship may minimize the effects of changes in ABP on the estimation of CVMR. The method developed provides insight into CVMR under transient breath-by-breath changes in CO(2)...
  99. ncbi request reprint Coronary artery calcium score, risk factors, and incident coronary heart disease events
    Timothy S Church
    The Cooper Institute, Dallas, TX 75230, United States
    Atherosclerosis 190:224-31. 2007
    ..We sought to identify a potential threshold of coronary artery calcium for clinical use and examine the predictive power of coronary artery calcium in individuals categorized using conventional coronary heart disease risk assessment...
  100. ncbi request reprint Urine acid-base compensation at simulated moderate altitude
    Ri Li Ge
    Research Center for High Altitude Medicine, Qinghai University, Xining, PR China
    High Alt Med Biol 7:64-71. 2006
    ....
  101. ncbi request reprint Scaling of diastolic intraventricular pressure gradients is related to filling time duration
    Zoran B Popovic
    Cardiovascular Imaging Center, The Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH 44195, USA
    Am J Physiol Heart Circ Physiol 291:H762-9. 2006
    ..65, P < 0.001). We conclude that IVPD decrease, while IVPG increase with decreasing animal size. High IVPG in small mammals may be an adaptive mechanism to short filling times...