B D Levine

Summary

Affiliation: Presbyterian Hospital of Dallas
Country: USA

Publications

  1. ncbi The Effect of Age-related Differences in Body Size and Composition on Cardiovascular Determinants of VO2max
    Graeme Carrick-Ranson
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75321
    J Gerontol A Biol Sci Med Sci 68:608-16. 2013
  2. ncbi The effect of exercise training on left ventricular relaxation and diastolic suction at rest and during orthostatic stress after bed rest
    Graeme Carrick-Ranson
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    Exp Physiol 98:501-13. 2013
  3. ncbi Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure
    Naoki Fujimoto
    University of Texas Southwestern Medical Center at Dallas
    Circulation 127:55-62. 2013
  4. ncbi Short-term exercise training improves the cardiovascular response to exercise in the postural orthostatic tachycardia syndrome
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 590:3495-505. 2012
  5. ncbi Effect of ageing on left ventricular compliance and distensibility in healthy sedentary humans
    Naoki Fujimoto
    The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Physiol 590:1871-80. 2012
  6. ncbi Cardiac output and sympathetic vasoconstrictor responses during upright tilt to presyncope in healthy humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    J Physiol 590:1839-48. 2012
  7. ncbi Dose-response of altitude training: how much altitude is enough?
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, Dallas, TX 75231, USA
    Adv Exp Med Biol 588:233-47. 2006
  8. ncbi Effect of altitude on football performance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, Texas 75231, USA
    Scand J Med Sci Sports 18:76-84. 2008
  9. ncbi Intermittent hypoxic training: fact and fancy
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas University of Texas Southwestern Medical Center at Dallas, 75231, USA
    High Alt Med Biol 3:177-93. 2002
  10. ncbi Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center Dallas, Texas, USA
    J Appl Physiol 99:2053-5. 2005

Detail Information

Publications104 found, 100 shown here

  1. ncbi The Effect of Age-related Differences in Body Size and Composition on Cardiovascular Determinants of VO2max
    Graeme Carrick-Ranson
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75321
    J Gerontol A Biol Sci Med Sci 68:608-16. 2013
    ..It is also unclear to what extent scaling size-related cardiovascular determinants of VO2max affects the interpretation of age-related differences...
  2. ncbi The effect of exercise training on left ventricular relaxation and diastolic suction at rest and during orthostatic stress after bed rest
    Graeme Carrick-Ranson
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    Exp Physiol 98:501-13. 2013
    ..Therefore, the reduction in upright SV after HDBR is more influenced by changes in LV loading conditions, namely left atrial pressure in the setting of LV remodelling, rather than ventricular relaxation and diastolic suction...
  3. ncbi Hemodynamic responses to rapid saline loading: the impact of age, sex, and heart failure
    Naoki Fujimoto
    University of Texas Southwestern Medical Center at Dallas
    Circulation 127:55-62. 2013
    ..However, the normal hemodynamic response to a volume challenge and how age and sex affect this relationship remain unknown...
  4. ncbi Short-term exercise training improves the cardiovascular response to exercise in the postural orthostatic tachycardia syndrome
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 590:3495-505. 2012
    ..023). There were no changes in any Doppler index after training. These results suggest that short-term exercise training improves physical fitness and cardiovascular responses during exercise in patients with POTS...
  5. ncbi Effect of ageing on left ventricular compliance and distensibility in healthy sedentary humans
    Naoki Fujimoto
    The University of Texas Southwestern Medical Center at Dallas, Dallas, TX, USA
    J Physiol 590:1871-80. 2012
    ..Thereafter, this LV stiffening is followed by LV volume contraction and remodelling after the age of 65...
  6. ncbi Cardiac output and sympathetic vasoconstrictor responses during upright tilt to presyncope in healthy humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, TX 75231, USA
    J Physiol 590:1839-48. 2012
    ..However, an intrinsic impairment of vasomotor responsiveness and sympathetic baroreflex function is not the cause of neurally mediated (pre)syncope in this population...
  7. ncbi Dose-response of altitude training: how much altitude is enough?
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, Dallas, TX 75231, USA
    Adv Exp Med Biol 588:233-47. 2006
    ....
  8. ncbi Effect of altitude on football performance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, Texas 75231, USA
    Scand J Med Sci Sports 18:76-84. 2008
    ....
  9. ncbi Intermittent hypoxic training: fact and fancy
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas University of Texas Southwestern Medical Center at Dallas, 75231, USA
    High Alt Med Biol 3:177-93. 2002
    ....
  10. ncbi Point: positive effects of intermittent hypoxia (live high:train low) on exercise performance are mediated primarily by augmented red cell volume
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center Dallas, Texas, USA
    J Appl Physiol 99:2053-5. 2005
  11. ncbi Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, Dallas, TX 75231, USA
    J Physiol 538:331-40. 2002
    ..We conclude that after 16 days of spaceflight, muscle sympathetic nerve responses to upright tilt are normal...
  12. ncbi .VO2max: what do we know, and what do we still need to know?
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    J Physiol 586:25-34. 2008
    ..The magnitude and mechanisms of cardiac phenotype plasticity remain uncertain and probably involve underlying genetic factors, as well as the length, duration, type, intensity and age of initiation of the training stimulus...
  13. ncbi Neural and nonneural mechanisms for sex differences in elderly hypertension: can exercise training help?
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Hypertension 52:787-94. 2008
  14. ncbi A 30-year follow-up of the Dallas Bedrest and Training Study: II. Effect of age on cardiovascular adaptation to exercise training
    D K McGuire
    Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 104:1358-66. 2001
    ..The improved aerobic power after training was primarily the result of peripheral adaptation, with no effective improvement in maximal oxygen delivery...
  15. ncbi Cardiovascular and sympathetic neural responses to handgrip and cold pressor stimuli in humans before, during and after spaceflight
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 544:653-64. 2002
    ..We conclude that modulation of muscle sympathetic neural outflow by muscle metaboreceptors and skin nociceptors is preserved during short duration spaceflight...
  16. ncbi Vasoconstrictor reserve and sympathetic neural control of orthostasis
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, Dallas, Tex 75231, USA
    Circulation 110:2931-7. 2004
    ..Vasoconstrictor reserve therefore may be one mechanism underlying individual variability in orthostatic intolerance...
  17. ncbi Persistent sympathetic activation during chronic antihypertensive therapy: a potential mechanism for long term morbidity?
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    Hypertension 45:513-21. 2005
    ....
  18. ncbi Effects of spaceflight on human calf hemodynamics
    D E Watenpaugh
    Department of Physiology, University of Texas Southwestern Medical Center, Dallas, Texas 75235, USA
    J Appl Physiol 90:1552-8. 2001
    ..No calf hemodynamic result exhibited obvious mechanistic implications for postflight orthostatic intolerance...
  19. ncbi Cascade model of ventricular-arterial coupling and arterial-cardiac baroreflex function for cardiovascular variability in humans
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 291:H2142-51. 2006
    ..A cascade model of ventricular-arterial coupling with the arterial-cardiac baroreflex contributes to the genesis of cardiovascular variability at the respiratory frequency...
  20. ncbi A 30-year follow-up of the Dallas Bedrest and Training Study: I. Effect of age on the cardiovascular response to exercise
    D K McGuire
    Pauline and Adolph Weinberger Laboratory for Cardiopulmonary Research, University of Texas Southwestern Medical Center, Dallas, TX 75390 9047, USA
    Circulation 104:1350-7. 2001
    ..Our study objective was to assess the effect of a 30-year interval on body composition and cardiovascular response to acute exercise in 5 healthy subjects originally evaluated in 1966...
  21. ncbi The effects of altitude training are mediated primarily by acclimatization, rather than by hypoxic exercise
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, USA
    Adv Exp Med Biol 502:75-88. 2001
    ....
  22. ncbi Dose-response relationship of the cardiovascular adaptation to endurance training in healthy adults: how much training for what benefit?
    Ken Ichi Iwasaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, and University of Texas Southwestern Medical Center at Dallas, Dallas, Texas 75231, USA
    J Appl Physiol 95:1575-83. 2003
    ....
  23. ncbi Vasomotor sympathetic neural control is maintained during sustained upright posture in humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center at Dallas, TX 75231, USA
    J Physiol 577:679-87. 2006
    ..e. 45 min) orthostasis without obvious changes in vasomotor sympathetic neural control...
  24. ncbi "Living high-training low": effect of moderate-altitude acclimatization with low-altitude training on performance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas 75231, Dallas, Texas 75235, USA
    J Appl Physiol 83:102-12. 1997
    ....
  25. ncbi Cardiac atrophy after bed-rest deconditioning: a nonneural mechanism for orthostatic intolerance
    B D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Tex 75321, USA
    Circulation 96:517-25. 1997
    ..We hypothesized that this large fall in SV is due to a change in cardiac mechanics...
  26. ncbi Evidence for unloading arterial baroreceptors during low levels of lower body negative pressure in humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, Texas, USA
    Am J Physiol Heart Circ Physiol 296:H480-8. 2009
    ..e., -10 and -15 mmHg) of LBNP in humans. Thus "selective" unloading of cardiopulmonary baroreceptors cannot be presumed to occur during these levels of mild LBNP...
  27. ncbi Dose-response relationship of endurance training for autonomic circulatory control in healthy seniors
    Kazunobu Okazaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    J Appl Physiol 99:1041-9. 2005
    ..Seniors retain a similar degree of "trainability" as young subjects for cardiac autonomic function to dynamic exercise...
  28. ncbi Human cerebral autoregulation before, during and after spaceflight
    Ken Ichi Iwasaki
    Institute for Exercise and Environmental Medicine, 7232 Greenville Avenue, Suite 435, Dallas, TX 75231, USA
    J Physiol 579:799-810. 2007
    ..We conclude that human cerebral autoregulation is preserved, and possibly even improved, by short-duration spaceflight...
  29. ncbi Effect of aging and physical activity on left ventricular compliance
    Armin Arbab-Zadeh
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, and University of Texas Southwestern Medical Center, Dallas, Tex 75231, USA
    Circulation 110:1799-805. 2004
    ..Prolonged, sustained endurance training preserves ventricular compliance with aging and may help to prevent heart failure in the elderly...
  30. ncbi Performance of runners and swimmers after four weeks of intermittent hypobaric hypoxic exposure plus sea level training
    Ferran A Rodríguez
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Dallas, TX 75231, USA
    J Appl Physiol 103:1523-35. 2007
    ..Whether there are potential benefits of this regimen for specific sports or training/tapering strategies may require further study...
  31. ncbi Effects of gender and hypovolemia on sympathetic neural responses to orthostatic stress
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and the University of Texas Southwestern Medical Center at Dallas, TX 75231, USA
    Am J Physiol Regul Integr Comp Physiol 289:R109-16. 2005
    ....
  32. ncbi Nitric oxide synthase inhibition does not affect regulation of muscle sympathetic nerve activity during head-up tilt
    Jian Cui
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 285:H2105-10. 2003
    ..These results suggest that systemic inhibition of NO synthase with L-NMMA does not affect the regulation of sympathetic outflow and vascular resistance during head-up tilt in humans...
  33. ncbi A forty-year follow-up of the Dallas Bed Rest and Training study: the effect of age on the cardiovascular response to exercise in men
    Jonathan M McGavock
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, 7232 Greenville Ave, Dallas, TX 75231, USA
    J Gerontol A Biol Sci Med Sci 64:293-9. 2009
    ..The aim of the present study was to reexamine these same men 40 years following the original assessments...
  34. ncbi 'Dynamic' Starling mechanism: effects of ageing and physical fitness on ventricular-arterial coupling
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    J Physiol 586:1951-62. 2008
    ..Life-long daily exercise training may minimize this impairment, although the effect may be limited particularly when started later in life...
  35. ncbi Effect of high-altitude exposure in the elderly: the Tenth Mountain Division study
    B D Levine
    The Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and Division of Cardiology, University of Texas Southwestern Medical Center at Dallas, USA
    Circulation 96:1224-32. 1997
    ..We hypothesized that the elderly would exhibit an impaired functional capacity at altitude, with increased myocardial ischemia compared with sea level (SL)...
  36. ncbi Deterioration of left ventricular chamber performance after bed rest : "cardiovascular deconditioning" or hypovolemia?
    M A Perhonen
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital and University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Circulation 103:1851-7. 2001
    ..We studied whether the reduction in SV is due to a specific adaptation of the heart to head-down tilt bed rest (HDTBR) or acute hypovolemia alone...
  37. ncbi Effect of increasing central venous pressure during passive heating on skin blood flow
    C G Crandall
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231, Texas, USA
    J Appl Physiol 86:605-10. 1999
    ..05). These data suggest that cardiopulmonary baroreceptor unloading during passive heating may attenuate the elevation in SkBF in humans, whereas loading cardiopulmonary baroreceptors in normothermia has no effect on SkBF...
  38. ncbi Cardiac origins of the postural orthostatic tachycardia syndrome
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Texas 75231, USA
    J Am Coll Cardiol 55:2858-68. 2010
    ..The purpose of this study was to test the hypothesis that a small heart coupled with reduced blood volume contributes to the postural orthostatic tachycardia syndrome (POTS) and that exercise training improves this syndrome...
  39. ncbi Comments on Point:Counterpoint: Sympathetic activity does/does not influence cerebral blood flow. Autonomic control of the cerebral circulation is most important for dynamic cerebral autoregulation
    Benjamin D Levine
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital, UT Southwestern, TX, USA
    J Appl Physiol 105:1369-73. 2008
  40. ncbi Hemodynamics of orthostatic intolerance: implications for gender differences
    Qi Fu
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 286:H449-57. 2004
    ..Thus cardiac mechanics and Frank-Starling relationship may be important mechanisms underlying the gender difference in orthostatic tolerance...
  41. ncbi Cardiac atrophy after bed rest and spaceflight
    M A Perhonen
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA
    J Appl Physiol 91:645-53. 2001
    ..We suggest that cardiac atrophy is due to a physiological adaptation to reduced myocardial load and work in real or simulated microgravity and demonstrates the plasticity of cardiac muscle under different loading conditions...
  42. ncbi Effect of high-intensity hypoxic training on sea-level swimming performances
    M J Truijens
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center at Dallas, 75231, USA
    J Appl Physiol 94:733-43. 2003
    ..58). We conclude that 5 wk of high-intensity training in a flume improves sea-level swimming performances and Vo(2 max) in well-trained swimmers, with no additive effect of hypoxic training...
  43. ncbi Cerebral hemodynamics after short- and long-term reduction in blood pressure in mild and moderate hypertension
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center, TX 75231, USA
    Hypertension 49:1149-55. 2007
    ....
  44. ncbi Menstrual cycle effects on sympathetic neural responses to upright tilt
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    J Physiol 587:2019-31. 2009
    ..Thus, other factors rather than sympathetic baroreflex control mechanisms contribute to sex differences in orthostatic tolerance in young humans...
  45. ncbi Menstrual cycle affects renal-adrenal and hemodynamic responses during prolonged standing in the postural orthostatic tachycardia syndrome
    Qi Fu
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, Dallas, Tex 75231, USA
    Hypertension 56:82-90. 2010
    ..The high estrogen and progesterone in the MLP are associated with greater increases in renal-adrenal hormones and presumably more volume retention, which improve late-standing tolerance in these patients...
  46. ncbi Dynamic pressure-flow relationship of the cerebral circulation during acute increase in arterial pressure
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    J Physiol 587:2567-77. 2009
    ..Thus, oscillations in CBFV are modulated not only by dynamic autoregulation, but also by changes in steady-state cerebrovascular resistance and/or vascular compliance...
  47. ncbi Autonomic circulatory control during pregnancy in humans
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Semin Reprod Med 27:330-7. 2009
    ....
  48. ncbi Intermittent hypobaric hypoxia exposure does not cause sustained alterations in autonomic control of blood pressure in young athletes
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Am J Physiol Regul Integr Comp Physiol 292:R1977-84. 2007
    ..In contrast to animal studies, we found no secondary evidence for sustained physiologically significant sympathoexcitation in this model...
  49. ncbi Arterial-cardiac baroreflex function: insights from repeated squat-stand maneuvers
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas and University of Texas Southwestern Medical Center, Dallas, TX 75231, USA
    Am J Physiol Regul Integr Comp Physiol 297:R116-23. 2009
    ..Furthermore, baroreflex function can be assessed using the transfer function method during large perturbations in arterial pressure...
  50. ncbi Cardiac atrophy in women following bed rest
    Todd A Dorfman
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    J Appl Physiol 103:8-16. 2007
    ..However, exercise training and, to a lesser extent, protein supplementation may be potential countermeasures to the cardiac atrophy associated with chronic unloading conditions such as in spaceflight and prolonged bed rest...
  51. ncbi Cardiovascular effects of 1 year of progressive and vigorous exercise training in previously sedentary individuals older than 65 years of age
    Naoki Fujimoto
    Institute for Exercise and Environmental Medicine, Dallas, TX 75231, USA
    Circulation 122:1797-805. 2010
    ..However, it is unknown whether exercise training started later in life can reverse the effects of sedentary behavior on the heart...
  52. ncbi Biological aortic age derived from the arterial pressure waveform
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, Dallas, Texas 75231, USA
    J Appl Physiol 110:981-7. 2011
    ....
  53. ncbi Autonomic ganglionic blockade does not prevent reduction in cerebral blood flow velocity during orthostasis in humans
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, TX 75231, USA
    Stroke 38:1238-44. 2007
    ..This study tested the hypothesis that sympathetic activation causes cerebral vasoconstriction leading to reductions in CBF during lower body negative pressure (LBNP)...
  54. ncbi Effect of skin surface cooling on central venous pressure during orthostatic challenge
    Jian Cui
    Inst. for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 289:H2429-33. 2005
    ..These data indicate that skin surface cooling induced an upward shift in CVP throughout LBNP, which may be a key factor for preserving preload, stroke volume, and blood pressure and improving orthostatic tolerance...
  55. ncbi Inhibition of nitric oxide synthase does not alter dynamic cerebral autoregulation in humans
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231, USA
    Am J Physiol Heart Circ Physiol 286:H863-9. 2004
    ..These data suggest that inhibition of tonic production of NO does not appear to alter dynamic cerebral autoregulation in humans...
  56. ncbi Cerebral hemodynamics during the Valsalva maneuver: insights from ganglionic blockade
    Rong Zhang
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, and University of Texas Southwestern Medical Center, Dallas, Tex 75231, USA
    Stroke 35:843-7. 2004
    ..The aim of this study was to differentiate the mechanical effects of the Valsalva maneuver (VM) from the effects of changes in autonomic neural activity on cerebral hemodynamics in humans...
  57. ncbi Supine cycling plus volume loading prevent cardiovascular deconditioning during bed rest
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Hospital Dallas, and University of Texas Southwestern Medical Center at Dallas, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    J Appl Physiol 108:1177-86. 2010
    ..This maintenance of orthostatic tolerance was achieved by neither exercise nor dextran infusion alone. Cardiac atrophy and hypovolemia are likely to contribute independently to orthostatic intolerance after bed rest...
  58. ncbi Effects of whole body heating on dynamic baroreflex regulation of heart rate in humans
    C G Crandall
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas 75231, USA
    Am J Physiol Heart Circ Physiol 279:H2486-92. 2000
    ..Reduced vagal baroreflex regulation of HR may contribute to reduced orthostatic tolerance known to occur in humans during heat stress...
  59. ncbi Vasoconstriction during venous congestion: effects of venoarteriolar response, myogenic reflexes, and hemodynamics of changing perfusion pressure
    Kazunobu Okazaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Ave, Suite 435, Dallas, Texas 75231, USA
    Am J Physiol Regul Integr Comp Physiol 289:R1354-9. 2005
    ..Finally, from both techniques, we calculated that during venous congestion induced by limb dependency (calf), approximately 45% of the nonbaroreflex vasoconstriction is induced by the VAR and approximately 55% by the myogenic reflex...
  60. ncbi Altitude training considerations for the winter sport athlete
    Robert F Chapman
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    Exp Physiol 95:411-21. 2010
    ..For competitions at sea level, the 'live high-train low' model of altitude training can help athletes in endurance events to maximize performance...
  61. ncbi Carotid sinus "irritability" rather than hypersensitivity: a new name for an old syndrome?
    C R Cole
    The Institute of Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA
    Clin Auton Res 11:109-13. 2001
    ....
  62. ncbi The effects of aging and physical activity on Doppler measures of diastolic function
    Anand Prasad
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital and University of Texas Southwestern Medical Center, Dallas, Texas, USA
    Am J Cardiol 99:1629-36. 2007
    ....
  63. ncbi Ventilatory responses to exercise and hypercapnia following 18 days of head-down rest
    Helen E Wood
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, University of Texas Southwestern Medical Center Dallas, Dallas, TX 75231, USA
    Aviat Space Environ Med 80:395-9. 2009
    ..Based on limited previous studies, we hypothesized that the ventilatory response to exercise would be increased, while the HCVR would be decreased after HDR...
  64. ncbi Maximal oxygen uptake as a parametric measure of cardiorespiratory capacity
    Megan N Hawkins
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, 7232 Greenville Avenue, Dallas, TX 75231, USA
    Med Sci Sports Exerc 39:103-7. 2007
    ..This concept has recently been disputed because of the lack of published data reporting an unequivocal plateau in .VO2 during incremental exercise...
  65. ncbi Exercise throughout 6 degrees head-down tilt bed rest preserves thermoregulatory responses
    Manabu Shibasaki
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, Texas 75231, USA
    J Appl Physiol 95:1817-23. 2003
    ..These data suggest that dynamic exercise during this short period of HDT bed rest preserves thermoregulatory responses...
  66. ncbi Coronary artery calcium score and coronary heart disease events in a large cohort of asymptomatic men and women
    Michael J LaMonte
    Centers for Integrated Health Research, The Cooper Institute, Dallas, TX 75230, USA
    Am J Epidemiol 162:421-9. 2005
    ..These findings show that CAC is associated with an increased risk of CHD events in asymptomatic women and men...
  67. ncbi Diastolic suction is impaired by bed rest: MRI tagging studies of diastolic untwisting
    Todd A Dorfman
    Institute for Exercise and Environmental Medicine, 7232 Greenville Ave, Suite 435, Dallas, TX 75231, USA
    J Appl Physiol 104:1037-44. 2008
    ..We conclude that diastolic untwisting is impaired following sedentary bed rest. However, exercise training in bed can prevent the physiological cardiac remodeling associated with bed rest and preserve or even enhance diastolic suction...
  68. ncbi Characterization of static and dynamic left ventricular diastolic function in patients with heart failure with a preserved ejection fraction
    Anand Prasad
    Institute for Exercise and Environmental Medicine, Texas Health Presbyterian Dallas, Dallas, Tex 75231, USA
    Circ Heart Fail 3:617-26. 2010
    ....
  69. ncbi Cardiovascular response to exercise in women
    Qi Fu
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, USA
    Med Sci Sports Exerc 37:1433-5. 2005
  70. ncbi Effects of pericardial constraint and ventricular interaction on left ventricular hemodynamics in the unloaded heart
    Naoki Fujimoto
    Institute for Exercise and Environmental Medicine, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 300:H1688-95. 2011
    ..These results suggest that the pericardium constrains LV filling during LBNP release, enough to cause a small but significant drop of SV, even at low cardiac filling pressure in healthy humans...
  71. ncbi Congestive heart failure with preserved ejection fraction is associated with severely impaired dynamic Starling mechanism
    Shigeki Shibata
    Institute for Exercise and Environmental Medicine, Dallas, TX 75231, USA
    J Appl Physiol 110:964-71. 2011
    ....
  72. ncbi Women have higher left ventricular ejection fractions than men independent of differences in left ventricular volume: the Dallas Heart Study
    Anne K Chung
    Donald W. Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9047, USA
    Circulation 113:1597-604. 2006
    ..A low LVEF was defined as below 61% in women and below 55% in men. CONCLUSIONS: Women have a higher LVEF than men in the general population, secondary to a higher stroke volume for a given EDV independent of known potential confounders...
  73. ncbi Comparison of coronary artery calcium detected by electron beam tomography in patients with to those without symptomatic coronary heart disease
    Yiling J Cheng
    The Cooper Institute, Dallas, Texas, USA
    Am J Cardiol 92:498-503. 2003
    ..These observations support the potential of EBT as a sensitive test for detection of CHD...
  74. ncbi Effects of heat stress on thermoregulatory responses in congestive heart failure patients
    Jian Cui
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Dallas, TX 75231, USA
    Circulation 112:2286-92. 2005
    ..Attenuated cutaneous vasodilation may be a potential mechanism for heat intolerance in patients with CHF...
  75. ncbi Obesity: associations with acute mountain sickness
    Ge Ri-Li
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital of Dallas, Texas 75231, USA
    Ann Intern Med 139:253-7. 2003
    ..CONCLUSION: Obesity seems to be associated with the development of AMS, which may be partly related to greater nocturnal desaturation with altitude exposure...
  76. ncbi The relationship of right- and left-sided filling pressures in patients with heart failure and a preserved ejection fraction
    Mark H Drazner
    Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Tex 75390 9047, USA
    Circ Heart Fail 3:202-6. 2010
    ..Although right-sided filling pressures often mirror left-sided filling pressures in systolic heart failure, it is not known whether a similar relationship exists in heart failure with preserved ejection fraction...
  77. ncbi Abnormalities of Doppler measures of diastolic function in the healthy elderly are not related to alterations of left atrial pressure
    Anand Prasad
    Institute for Exercise and Environmental Medicine, Presbyterian Hospital and the University of Texas Southwestern Medical Center at Dallas, TX 75231, USA
    Circulation 111:1499-503. 2005
    ..CONCLUSIONS: We conclude that the age-related echocardiographic change of decreasing E/A ratio is not the result of a lowering of early diastolic left atrial pressure...
  78. ncbi Cardiac systolic and diastolic function during whole body heat stress
    R Matthew Brothers
    Presbyterian Hospital of Dallas, Institute of Exercise and Environmental Medicine, 7232 Greenville Ave, Ste 435, Dallas, TX 75231, USA
    Am J Physiol Heart Circ Physiol 296:H1150-6. 2009
    ..Together these data support previous findings, which used the less precise measure of ejection fraction, that heat stress improves indexes of systolic function, while diastolic function is maintained...
  79. ncbi Cerebral hemodynamics during orthostatic stress assessed by nonlinear modeling
    Georgios D Mitsis
    Department of Biomedical Engineering, University of Southern California, Los Angeles, USA
    J Appl Physiol 101:354-66. 2006
    ....
  80. ncbi Effects of 14 days of head-down tilt bed rest on cutaneous vasoconstrictor responses in humans
    Thad E Wilson
    Presbyterian Hosp, Dallas, TX
    J Appl Physiol 94:2113-8. 2003
    ..It remains unclear whether attenuated venoarteriolar responses in the lower limbs contribute to reduced orthostatic tolerance after bed rest and spaceflight...
  81. ncbi Autonomic neural control of dynamic cerebral autoregulation in humans
    Rong Zhang
    Presbyterian Hosp, Dallas, TX
    Circulation 106:1814-20. 2002
    ..We speculate that autonomic neural control of the cerebral circulation is tonically active and likely plays a significant role in the regulation of beat-to-beat CBF in humans...
  82. ncbi Relationship among diastolic intraventricular pressure gradients, relaxation, and preload: impact of age and fitness
    Zoran B Popovic
    Cardiovascular Imaging Center, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA
    Am J Physiol Heart Circ Physiol 290:H1454-9. 2006
    ..The ability to regulate IVPGs during changes in preload is impaired with aging. Preserving ventricular compliance during aging by lifelong exercise training does not prevent this impairment...
  83. ncbi Hypertension and antihypertensive therapy in elderly women: how much do we really know?
    Qi Fu
    Hypertension 47:323-4. 2006
  84. ncbi Reduced baroreflex control of heart period after bed rest is normalized by acute plasma volume restoration
    Ken-Ichi Iwasaki
    Presbyterian Hosp, Dallas, TX
    Am J Physiol Regul Integr Comp Physiol 287:R1256-62. 2004
    ....
  85. ncbi Mechanism of blood pressure and R-R variability: insights from ganglion blockade in humans
    Rong Zhang
    U TX SW Med Ctr, Dallas
    J Physiol 543:337-48. 2002
    ....
  86. ncbi Increased serum erythropoietin but not red cell production after 4 wk of intermittent hypobaric hypoxia (4,000-5,500 m)
    Christopher J Gore
    Australian Institute of Sport, Canberra, Australia
    J Appl Physiol 101:1386-93. 2006
    ....
  87. ncbi Heterogeneous responses of human limbs to infused adrenergic agonists: a gravitational effect?
    James A Pawelczyk
    Noll Physiological Research Center and Department of Kinesiology, The Pennsylvania State University, University Park, PA 16802, USA
    J Appl Physiol 92:2105-13. 2002
    ..The relatively greater response to alpha1-adrenergic-receptor stimulation in the calf may represent an adaptive mechanism that limits blood pooling and capillary filtration in the legs during standing...
  88. ncbi Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space
    Andrew C Ertl
    Vanderbilt University Medical Center, Nashville, TN, USA
    J Physiol 538:321-9. 2002
    ..Therefore, notwithstanding hypovolaemia, astronauts respond normally to simulated orthostatic stress and are able to maintain their arterial pressures at normal levels...
  89. ncbi Transcranial Doppler estimation of cerebral blood flow and cerebrovascular conductance during modified rebreathing
    Jurgen A H R Claassen
    Department of Geriatric Medicine, Radbound University Nijmegen Medical Center, The Netherlands
    J Appl Physiol 102:870-7. 2007
    ..Furthermore, quantification of the CVCi-Pet(CO(2)) relationship may minimize the effects of changes in ABP on the estimation of CVMR. The method developed provides insight into CVMR under transient breath-by-breath changes in CO(2)...
  90. ncbi The effect of intermittent hypobaric hypoxic exposure and sea level training on submaximal economy in well-trained swimmers and runners
    Martin J Truijens
    Faculty of Human Movement Sciences, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
    J Appl Physiol 104:328-37. 2008
    ..No differences in submaximal HR, [La-], Ve, or velocity at V(.-)o2(max) were found between groups. It is concluded that 4 wk of intermittent hypobaric hypoxia did not improve submaximal economy in this group of well-trained athletes...
  91. ncbi Dynamic autoregulation of cutaneous circulation: differential control in glabrous versus nonglabrous skin
    Thad E Wilson
    U TX SW Med Ctr, Dallas, TX
    Am J Physiol Heart Circ Physiol 289:H385-91. 2005
    ..Conversely, these data suggest that nonglabrous skin has diminished dynamic autoregulatory capabilities...
  92. ncbi Intermittent normobaric hypoxia does not alter performance or erythropoietic markers in highly trained distance runners
    Colleen G Julian
    Sports Medicine Institute International, Palo Alto, California 94300, USA
    J Appl Physiol 96:1800-7. 2004
    ..Four weeks of a 5:5-min normobaric hypoxia exposure at rest for 70 min, 5 days/wk, is not a sufficient stimulus to elicit improved performance or change the normal level of erythropoiesis in highly trained runners...
  93. ncbi Endothelin and aged blood vessels: one more reason to get off the couch?
    Dick H J Thijssen
    Hypertension 50:292-3. 2007
  94. ncbi Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre
    James F Cox
    Department of Medicine and Physiology, Hunter Holmes McGuire Veterans Affairs Medical Center and Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia, USA 23249
    J Physiol 538:309-20. 2002
    ..This and earlier research suggest that exposure of healthy humans to microgravity augments arterial pressure and sympathetic responses to Valsalva straining and differentially reduces vagal, but not sympathetic baroreflex gain...
  95. ncbi Effect of hypoxic "dose" on physiological responses and sea-level performance
    Randall L Wilber
    Athlete Performance Laboratory, United States Olympic Committee, Colorado Springs, CO 80909, USA
    Med Sci Sports Exerc 39:1590-9. 2007
    ..d(-1)...
  96. ncbi Climbing risks with a patent foramen ovale
    Benjamin D Levine
    High Alt Med Biol 5:25-6. 2004
  97. ncbi Cyclooxygenase-2 inhibition with celecoxib enhances antitumor efficacy and reduces diarrhea side effect of CPT-11
    Ovidiu C Trifan
    Oncology Pharmacology, Pharmacia Corp, Chesterfield, Missouri 63198, USA
    Cancer Res 62:5778-84. 2002
    ..The extended benefits of combining celecoxib with CPT-11 may significantly improve the outcome of cancer patients...
  98. ncbi Urine acid-base compensation at simulated moderate altitude
    Ri-Li Ge
    Research Center for High Altitude Medicine, Qinghai University, Xining, PR China
    High Alt Med Biol 7:64-71. 2006
    ....
  99. ncbi Sudden death in patients with myocardial infarction
    Amit Khera
    N Engl J Med 353:1294-7; author reply 1294-7. 2005
  100. ncbi Does nitric oxide buffer arterial blood pressure variability in humans?
    William H Cooke
    Department of Biomedical Engineering and Biological Sciences, Michigan Technological University, Houghton, Michigan 49931, USA
    J Appl Physiol 93:1466-70. 2002
    ....
  101. ncbi Coronary artery calcium score, risk factors, and incident coronary heart disease events
    Timothy S Church
    The Cooper Institute, Dallas, TX 75230, United States
    Atherosclerosis 190:224-31. 2007
    ..We sought to identify a potential threshold of coronary artery calcium for clinical use and examine the predictive power of coronary artery calcium in individuals categorized using conventional coronary heart disease risk assessment...