Jocelyn H Wright
Affiliation: Preclinical Research and Exploratory Development
- Mitogen-activated protein kinase kinase activity is required for the G(2)/M transition of the cell cycle in mammalian fibroblastsJ H Wright
Department of Pharmacology, University of Washington, Seattle, WA 98103, USA
Proc Natl Acad Sci U S A 96:11335-40. 1999..These data demonstrate a novel role for the MAPK cascade in progression from G(2) into mitosis in NIH 3T3 cells...
- The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesionJocelyn H Wright
SUGEN, Inc, South San Francisco, California 94080, USA
Mol Cell Biol 23:2068-82. 2003..Together, these results suggest an important role for HGK in cell transformation and invasiveness...
- Defective DNA strand break repair causes chromosomal instability and accelerates liver carcinogenesis in miceNarci C Teoh
Australian National University Medical School, Canberra, Australia
Hepatology 47:2078-88. 2008..CONCLUSION: These findings demonstrate that defects in the NHEJ DNA repair pathway may participate in the disruption of cell cycle checkpoints leading to chromosomal instability and accelerated development of HCC...