G Manning

Summary

Affiliation: Preclinical Research and Exploratory Development
Country: USA

Publications

  1. ncbi The protein kinase complement of the human genome
    G Manning
    SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Science 298:1912-34. 2002
  2. ncbi Evolution of protein kinase signaling from yeast to man
    Gerard Manning
    Sugen Inc 230 East Grand Ave, South San Francisco, CA 94080, USA
    Trends Biochem Sci 27:514-20. 2002
  3. pmc The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
    Nicole King
    Department of Molecular and Cell Biology and the Center for Integrative Genomics, University of California, Berkeley, California 94720, USA
    Nature 451:783-8. 2008
  4. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
  5. ncbi The sea urchin kinome: a first look
    Cynthia A Bradham
    DCMB Group, Duke University, Box 91000, Durham, NC 27708, USA
    Dev Biol 300:180-93. 2006
  6. pmc Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote
    Jonathan A Eisen
    The Institute for Genomic Research, Rockville, Maryland, United States of America
    PLoS Biol 4:e286. 2006
  7. pmc Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
    PAUL E O'MAILLE
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H Skirball Center for Chemical Biology and Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Chem Biol 4:617-23. 2008
  8. pmc The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion
    Jocelyn H Wright
    SUGEN, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 23:2068-82. 2003
  9. pmc The mouse kinome: discovery and comparative genomics of all mouse protein kinases
    Sean Caenepeel
    SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA
    Proc Natl Acad Sci U S A 101:11707-12. 2004
  10. pmc The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan
    Gerard Manning
    Razavi Newman Center for Bioinformatics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:9674-9. 2008

Collaborators

Detail Information

Publications16

  1. ncbi The protein kinase complement of the human genome
    G Manning
    SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
    Science 298:1912-34. 2002
    ..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons...
  2. ncbi Evolution of protein kinase signaling from yeast to man
    Gerard Manning
    Sugen Inc 230 East Grand Ave, South San Francisco, CA 94080, USA
    Trends Biochem Sci 27:514-20. 2002
    ....
  3. pmc The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans
    Nicole King
    Department of Molecular and Cell Biology and the Center for Integrative Genomics, University of California, Berkeley, California 94720, USA
    Nature 451:783-8. 2008
    ..The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans...
  4. pmc The genome of the sea urchin Strongylocentrotus purpuratus
    Erica Sodergren
    Science 314:941-52. 2006
    ..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes...
  5. ncbi The sea urchin kinome: a first look
    Cynthia A Bradham
    DCMB Group, Duke University, Box 91000, Durham, NC 27708, USA
    Dev Biol 300:180-93. 2006
    ..These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism...
  6. pmc Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryote
    Jonathan A Eisen
    The Institute for Genomic Research, Rockville, Maryland, United States of America
    PLoS Biol 4:e286. 2006
    ..thermophila an ideal model for functional genomic studies to address biological, biomedical, and biotechnological questions of fundamental importance...
  7. pmc Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthases
    PAUL E O'MAILLE
    Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H Skirball Center for Chemical Biology and Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
    Nat Chem Biol 4:617-23. 2008
    ..These results provide a measure of the mutational accessibility of phenotypic variability in a diverging lineage of terpene synthases...
  8. pmc The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion
    Jocelyn H Wright
    SUGEN, Inc, South San Francisco, California 94080, USA
    Mol Cell Biol 23:2068-82. 2003
    ..Together, these results suggest an important role for HGK in cell transformation and invasiveness...
  9. pmc The mouse kinome: discovery and comparative genomics of all mouse protein kinases
    Sean Caenepeel
    SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA
    Proc Natl Acad Sci U S A 101:11707-12. 2004
    ..Chromosomal mapping links 163 kinases to mutant phenotypes and unlocks the use of mouse genetics to determine functions of orthologous human kinases...
  10. pmc The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoan
    Gerard Manning
    Razavi Newman Center for Bioinformatics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
    Proc Natl Acad Sci U S A 105:9674-9. 2008
    ....
  11. ncbi Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptors
    Marilyn H Perrin
    The Clayton Foundation Laboratories for Peptide Biology, La Jolla, CA 92037, USA
    J Biol Chem 282:37529-36. 2007
    ..Because homologous mutations in other B1 receptors produce similar effects, these conserved residues may play similar roles in the entire receptor family...
  12. ncbi Genomic minimalism in the early diverging intestinal parasite Giardia lamblia
    Hilary G Morrison
    Marine Biological Laboratory, Woods Hole, MA 02543 1015, USA
    Science 317:1921-6. 2007
    ..This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite...
  13. pmc Structural and functional diversity of the microbial kinome
    Natarajan Kannan
    Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
    PLoS Biol 5:e17. 2007
    ..We show that loss of a catalytic lysine in two families is compensated by distinct mechanisms both involving other key motifs. This diverse superfamily serves as a model for further structural and functional analysis of enzyme evolution...
  14. pmc The dictyostelium kinome--analysis of the protein kinases from a simple model organism
    Jonathan M Goldberg
    Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America
    PLoS Genet 2:e38. 2006
    ..This study offers insights into kinase evolution and provides a focus for signaling analysis in this system...
  15. pmc Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanisms
    Dorota Wloga
    Department of Cellular Biology, University of Georgia, Athens, GA 30602 2607, USA
    Mol Biol Cell 17:2799-810. 2006
    ..We also show that normal Tetrahymena cells maintain unequal length cilia. We propose that ciliates used a large number of NRK paralogues to differentially regulate the length of specific subsets of cilia in the same cell...
  16. pmc Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3G
    Bärbel Schröfelbauer
    Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    J Virol 80:5984-91. 2006
    ..These findings provide insight into the interaction of Vif with A3G and are a step toward the development of a novel primate model for AIDS...