Genomes and Genes
Affiliation: Preclinical Research and Exploratory Development
- Evolution of protein kinase signaling from yeast to manGerard Manning
Sugen Inc 230 East Grand Ave, South San Francisco, CA 94080, USA
Trends Biochem Sci 27:514-20. 2002....
- The protein kinase complement of the human genomeG Manning
SUGEN Inc, 230 East Grand Avenue, South San Francisco, CA 94080, USA
Science 298:1912-34. 2002..We also identified 106 protein kinase pseudogenes. Chromosomal mapping revealed several small clusters of kinase genes and revealed that 244 kinases map to disease loci or cancer amplicons...
- The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoansNicole King
Department of Molecular and Cell Biology and the Center for Integrative Genomics, University of California, Berkeley, California 94720, USA
Nature 451:783-8. 2008..The completion of the M. brevicollis genome allows us to reconstruct with increasing resolution the genomic changes that accompanied the origin of metazoans...
- The genome of the sea urchin Strongylocentrotus purpuratusErica Sodergren
Science 314:941-52. 2006..This echinoderm genome provides an evolutionary outgroup for the chordates and yields insights into the evolution of deuterostomes...
- The sea urchin kinome: a first lookCynthia A Bradham
DCMB Group, Duke University, Box 91000, Durham, NC 27708, USA
Dev Biol 300:180-93. 2006..These results support the strength of this nonchordate deuterostome as a pivotal developmental and evolutionary model organism...
- Macronuclear genome sequence of the ciliate Tetrahymena thermophila, a model eukaryoteJonathan A Eisen
The Institute for Genomic Research, Rockville, Maryland, United States of America
PLoS Biol 4:e286. 2006..thermophila an ideal model for functional genomic studies to address biological, biomedical, and biotechnological questions of fundamental importance...
- Quantitative exploration of the catalytic landscape separating divergent plant sesquiterpene synthasesPAUL E O'MAILLE
Howard Hughes Medical Institute, The Salk Institute for Biological Studies, Jack H Skirball Center for Chemical Biology and Proteomics, 10010 North Torrey Pines Road, La Jolla, California 92037, USA
Nat Chem Biol 4:617-23. 2008..These results provide a measure of the mutational accessibility of phenotypic variability in a diverging lineage of terpene synthases...
- The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesionJocelyn H Wright
SUGEN, Inc, South San Francisco, California 94080, USA
Mol Cell Biol 23:2068-82. 2003..Together, these results suggest an important role for HGK in cell transformation and invasiveness...
- The mouse kinome: discovery and comparative genomics of all mouse protein kinasesSean Caenepeel
SUGEN, Incorporated, 230 East Grand Avenue, South San Francisco, CA 94025, USA
Proc Natl Acad Sci U S A 101:11707-12. 2004..Chromosomal mapping links 163 kinases to mutant phenotypes and unlocks the use of mouse genetics to determine functions of orthologous human kinases...
- The protist, Monosiga brevicollis, has a tyrosine kinase signaling network more elaborate and diverse than found in any known metazoanGerard Manning
Razavi Newman Center for Bioinformatics, Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA
Proc Natl Acad Sci U S A 105:9674-9. 2008....
- Distinct structural and functional roles of conserved residues in the first extracellular domain of receptors for corticotropin-releasing factor and related G-protein-coupled receptorsMarilyn H Perrin
The Clayton Foundation Laboratories for Peptide Biology, La Jolla, CA 92037, USA
J Biol Chem 282:37529-36. 2007..Because homologous mutations in other B1 receptors produce similar effects, these conserved residues may play similar roles in the entire receptor family...
- Genomic minimalism in the early diverging intestinal parasite Giardia lambliaHilary G Morrison
Marine Biological Laboratory, Woods Hole, MA 02543 1015, USA
Science 317:1921-6. 2007..This genome sequence will not only be valuable for investigating the evolution of eukaryotes, but will also be applied to the search for new therapeutics for this parasite...
- Structural and functional diversity of the microbial kinomeNatarajan Kannan
Department of Chemistry and Biochemistry, University of California San Diego, La Jolla, California, United States of America
PLoS Biol 5:e17. 2007..We show that loss of a catalytic lysine in two families is compensated by distinct mechanisms both involving other key motifs. This diverse superfamily serves as a model for further structural and functional analysis of enzyme evolution...
- The dictyostelium kinome--analysis of the protein kinases from a simple model organismJonathan M Goldberg
Boston Biomedical Research Institute, Watertown, Massachusetts, United States of America
PLoS Genet 2:e38. 2006..This study offers insights into kinase evolution and provides a focus for signaling analysis in this system...
- Members of the NIMA-related kinase family promote disassembly of cilia by multiple mechanismsDorota Wloga
Department of Cellular Biology, University of Georgia, Athens, GA 30602-2607, USA
Mol Biol Cell 17:2799-810. 2006..We also show that normal Tetrahymena cells maintain unequal length cilia. We propose that ciliates used a large number of NRK paralogues to differentially regulate the length of specific subsets of cilia in the same cell...
- Mutational alteration of human immunodeficiency virus type 1 Vif allows for functional interaction with nonhuman primate APOBEC3GBärbel Schröfelbauer
Infectious Disease Laboratory, The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
J Virol 80:5984-91. 2006..These findings provide insight into the interaction of Vif with A3G and are a step toward the development of a novel primate model for AIDS...