Ronald J Hill

Summary

Affiliation: Preclinical Research and Exploratory Development
Country: USA

Publications

  1. ncbi request reprint The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation
    Ronald J Hill
    Research Department, SUGEN, Inc, South San Francisco, CA 94080, USA
    Exp Hematol 30:237-44. 2002
  2. ncbi request reprint Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue
    Sarah A Walter
    Department of Research, SUGEN Inc, South San Francisco, California 94080, USA
    J Biol Chem 278:18221-8. 2003
  3. ncbi request reprint The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design
    Jennifer A Carmichael
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 280:22258-69. 2005
  4. ncbi request reprint Role of PYK2 in the development of obesity and insulin resistance
    Ying Yu
    Pfizer Global Research and Development, Cardiovascular Pharmacology, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
    Biochem Biophys Res Commun 334:1085-91. 2005
  5. ncbi request reprint Purification and characterization of recombinant ligand-binding domains from the ecdysone receptors of four pest insects
    Lloyd D Graham
    CSIRO Molecular and Health Technologies, Sydney Laboratory, P O Box 184, North Ryde, NSW 1670, Australia
    Protein Expr Purif 53:309-24. 2007
  6. ncbi request reprint Chromosome microdissection identifies genomic amplifications associated with drug resistance in a leukemia cell line: an approach to understanding drug resistance in cancer
    Frouzandeh Mahjoubi
    Clinical Genetic Department, National Research Institute of Genetic Engineering and Biotechnology NIGEB, Pazhoohesh Boulevard, Tehran Keraj Highway, Tehran, Iran
    Chromosome Res 14:263-76. 2006
  7. ncbi request reprint Activation mechanism and steady state kinetics of Bruton's tyrosine kinase
    Marie Dinh
    Department of Biochemical Pharmacology, Roche Palo Alto LLC, CA 94304, USA
    J Biol Chem 282:8768-76. 2007

Collaborators

  • L D Graham
  • Sarah A Walter
  • David Winkler
  • V Chandana Epa
  • Jeffrey J Gorman
  • Marie Dinh
  • Frouzandeh Mahjoubi
  • Ying Yu
  • Jennifer A Carmichael
  • Stan Y Tsing
  • Dorit Grunberger
  • Simon Lee
  • Jim Barnett
  • David Shaw
  • Hoangdung Ho
  • J Michael Bradshaw
  • David C Swinney
  • Greg B Peters
  • Garry N Hannan
  • Leonie Noyce
  • Eric A Gulve
  • Stuart A Ross
  • Brian R Bond
  • Ruth E Eaton
  • Amy E Halseth
  • Patricia A Pilling
  • Michael C Lawrence
  • Anna Pawlak-Skrzecz
  • Paul W Hollenbach
  • George Lovrecz

Detail Information

Publications7

  1. ncbi request reprint The lymphoid protein tyrosine phosphatase Lyp interacts with the adaptor molecule Grb2 and functions as a negative regulator of T-cell activation
    Ronald J Hill
    Research Department, SUGEN, Inc, South San Francisco, CA 94080, USA
    Exp Hematol 30:237-44. 2002
    ..We have attempted to identify new signaling molecules that are important for the activation response...
  2. ncbi request reprint Stk10, a new member of the polo-like kinase kinase family highly expressed in hematopoietic tissue
    Sarah A Walter
    Department of Research, SUGEN Inc, South San Francisco, California 94080, USA
    J Biol Chem 278:18221-8. 2003
    ..We suggest, therefore, that Stk10 is a novel polo-like kinase kinase that cooperates with hSlk to regulate Plk1 function in human cells...
  3. ncbi request reprint The X-ray structure of a hemipteran ecdysone receptor ligand-binding domain: comparison with a lepidopteran ecdysone receptor ligand-binding domain and implications for insecticide design
    Jennifer A Carmichael
    CSIRO Health Sciences and Nutrition, 343 Royal Parade, Parkville, Victoria 3052, Australia
    J Biol Chem 280:22258-69. 2005
    ..We suggest that these differences in the ligand-binding pocket may provide a molecular basis for the taxonomic order selectivity of bisacylhydrazine insecticides...
  4. ncbi request reprint Role of PYK2 in the development of obesity and insulin resistance
    Ying Yu
    Pfizer Global Research and Development, Cardiovascular Pharmacology, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
    Biochem Biophys Res Commun 334:1085-91. 2005
    ....
  5. ncbi request reprint Purification and characterization of recombinant ligand-binding domains from the ecdysone receptors of four pest insects
    Lloyd D Graham
    CSIRO Molecular and Health Technologies, Sydney Laboratory, P O Box 184, North Ryde, NSW 1670, Australia
    Protein Expr Purif 53:309-24. 2007
    ..Certain intra- and intermolecular disulfide bonds were observed to form in the absence of reducing agents, and thiol-specific alkylation was shown to suppress this phenomenon but to introduce microheterogeneity...
  6. ncbi request reprint Chromosome microdissection identifies genomic amplifications associated with drug resistance in a leukemia cell line: an approach to understanding drug resistance in cancer
    Frouzandeh Mahjoubi
    Clinical Genetic Department, National Research Institute of Genetic Engineering and Biotechnology NIGEB, Pazhoohesh Boulevard, Tehran Keraj Highway, Tehran, Iran
    Chromosome Res 14:263-76. 2006
    ..The DNA prepared from the amplified regions by chromosome microdissection provides a resource for future investigations looking for the possible presence of novel genes contributing to drug resistance...
  7. ncbi request reprint Activation mechanism and steady state kinetics of Bruton's tyrosine kinase
    Marie Dinh
    Department of Biochemical Pharmacology, Roche Palo Alto LLC, CA 94304, USA
    J Biol Chem 282:8768-76. 2007
    ..This investigation of BTK provides the first detailed kinetic characterization of a Tec family kinase...