- The search for gamma-secretase and development of inhibitorsJui Yi Tsai
PPG Industrial, 440 College Park Drive, Monroeville, PA 15146, USA
Curr Med Chem 9:1087-106. 2002..In this article, we review the current knowledge of gamma-secretase biochemistry and cell biology and the development of inhibitors of this important therapeutic target...
- Designed helical peptides inhibit an intramembrane proteaseChittaranjan Das
Center for Neurologic Diseases, Harvard Medical School, Boston, Massachusetts 02115, USA
J Am Chem Soc 125:11794-5. 2003..These findings are consistent with helical peptides interacting with the initial substrate docking site of gamma-secretase, suggesting a general strategy for the development of potent and specific inhibitors of intramembrane proteases...