Wayne E Steinmetz

Summary

Affiliation: Pomona College
Country: USA

Publications

  1. ncbi request reprint The structure of erythromycin enol ether as a model for its activity as a motilide
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, California 91711 6338, USA
    J Med Chem 45:4899-902. 2002
  2. ncbi request reprint Determination of the three-dimensional, solution-phase structure of the macrolide antibiotic oxolide in CD2Cl2 and D2O from NMR constraints
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, California 91711, USA
    Magn Reson Chem 43:16-20. 2005
  3. doi request reprint Structure and conformational dynamics of trichothecene mycotoxins
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, California 91711, USA
    J Nat Prod 71:589-94. 2008
  4. doi request reprint 3D QSAR study of the toxicity of trichothecene mycotoxins
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, CA 91711, USA
    Eur J Med Chem 44:4485-9. 2009
  5. doi request reprint NMR studies of the conformation of the natural sweetener rebaudioside A
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, CA 91711, United States
    Carbohydr Res 344:2533-8. 2009
  6. doi request reprint NMR assignment and characterization of proton exchange of the ellagitannin granatin B
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, CA 91711, USA
    Magn Reson Chem 48:565-70. 2010
  7. ncbi request reprint On the role of polarizability in chemical-biological interactions
    Corwin Hansch
    Department of Chemistry, Pomona College, Claremont, California 91711, BioByte Corp, Claremont, California 91711, USA
    J Chem Inf Comput Sci 43:120-5. 2003
  8. ncbi request reprint Structure-selectivity relationships and structure for a peptide-based enantioselective acylation catalyst
    Matthew B Fierman
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467 3860, USA
    J Am Chem Soc 126:6967-71. 2004

Collaborators

Detail Information

Publications8

  1. ncbi request reprint The structure of erythromycin enol ether as a model for its activity as a motilide
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, California 91711 6338, USA
    J Med Chem 45:4899-902. 2002
    ..Furthermore, a superposition of the structures of the enol ether and motilin shows a striking overlap of the sugar rings attached to the macrolide ring with essential aromatic side chains in the peptide...
  2. ncbi request reprint Determination of the three-dimensional, solution-phase structure of the macrolide antibiotic oxolide in CD2Cl2 and D2O from NMR constraints
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, California 91711, USA
    Magn Reson Chem 43:16-20. 2005
    ..The calculations yielded a well-defined global minimum. Data acquired for oxolide in D2O, although not as complete, indicate that the antibiotic adopts the same conformation in water...
  3. doi request reprint Structure and conformational dynamics of trichothecene mycotoxins
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, California 91711, USA
    J Nat Prod 71:589-94. 2008
    ..In contrast, roridin A is present as a mixture of two conformers...
  4. doi request reprint 3D QSAR study of the toxicity of trichothecene mycotoxins
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, CA 91711, USA
    Eur J Med Chem 44:4485-9. 2009
    ..The results show the role of electrostatics and steric factors in the activity of the toxins and indicate that the conformation of the macrolide ring influences the toxicity of the macrolide toxins...
  5. doi request reprint NMR studies of the conformation of the natural sweetener rebaudioside A
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, CA 91711, United States
    Carbohydr Res 344:2533-8. 2009
    ..Hydrogen bonding was examined using the temperature coefficients of the hydroxyl chemical shifts, ROESY and long-range COSY spectra, and proton-proton coupling constants...
  6. doi request reprint NMR assignment and characterization of proton exchange of the ellagitannin granatin B
    Wayne E Steinmetz
    Chemistry Department, Pomona College, Claremont, CA 91711, USA
    Magn Reson Chem 48:565-70. 2010
    ..The new NMR spectra also yield exchange rates for the hydroxyl protons as a function of temperature. A molecular model involving hydrogen bonding provides an explanation for the exchange data...
  7. ncbi request reprint On the role of polarizability in chemical-biological interactions
    Corwin Hansch
    Department of Chemistry, Pomona College, Claremont, California 91711, BioByte Corp, Claremont, California 91711, USA
    J Chem Inf Comput Sci 43:120-5. 2003
    ..The point is made that no matter how one approaches QSAR, electronic interactions must be considered if we are to begin to develop a science of chemical-biological interactions...
  8. ncbi request reprint Structure-selectivity relationships and structure for a peptide-based enantioselective acylation catalyst
    Matthew B Fierman
    Department of Chemistry, Merkert Chemistry Center, Boston College, Chestnut Hill, Massachusetts 02467 3860, USA
    J Am Chem Soc 126:6967-71. 2004
    ..In addition, an experimentally derived solution structure of the peptide-based catalyst is presented that supports a key role for each residue within the peptide chain...