D Weycker

..Our study suggests that better adherence with bisphosphonates confers tangible benefits in terms of graded increases in bone mineral density. Interventions to improve drug adherence should be an important component of disease management...

..The accuracy of methods previously used to identify FN in such databases has not been formally evaluated...

..Economic implications of chemotherapy-induced febrile neutropenia (FN) in European and Australian clinical practice are largely unknown...

..The potential public health and economic impact of PCV13 in this population is unknown...

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..In the current era of US clinical practice, chemotherapy dose delays and dose reductions are common among women with ESBC receiving frequently used myelosuppressive dose-dense, as well as conventional, chemotherapy regimens...

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..To characterize healthcare resource utilization and costs in patients with metastatic lung cancer receiving chemotherapy in the US...

..In this study, we characterize healthcare utilization and costs in the US among women with metastatic breast cancer receiving chemotherapy as their principal treatment modality...

..Patient compliance with pharmacotherapy for osteoporosis is typically poor in clinical practice; less frequent dosing with bisphosphonates may improve compliance...

..To describe the real-world effectiveness of amlodipine add-on therapy for hypertensive patients receiving valsartan...

..7 billion and $1.8 billion, respectively. Pneumococcal disease remains a substantial burden among older US adults, despite increased coverage with PPV23 and indirect benefits afforded by PCV7 vaccination of young children...

..On an overall basis, Rotarix would reduce costs by $77.2 million (95% CI $71.5-$86.5). Similar reductions with Rotarix were estimated to occur under an assumption of incomplete immunization of children...

..However, there is limited information on the comparative effectiveness of these agents in clinical practice...

..The aim of this work was to retrospectively examine the costs of therapy with etanercept and infliximab, among patients aged > or = 65 years with rheumatoid arthritis (RA), from a health-care system perspective...

..To describe the real-world effectiveness of amlodipine add-on therapy for hypertensive patients receiving valsartan...

..CONCLUSIONS: Adding amlodipine to valsartan for treatment of hypertension results in clinically meaningful reductions in blood pressure, on an overall basis and in high-risk subgroups who may benefit the most from blood pressure control...

..Patient compliance with osteoporosis drug therapy is often poor in clinical practice and may be associated with higher risk of fracture...

..79, 95% CI 0.68-0.92). Our study thus corroborates the finding from VALUE that diabetes risk is lower for patients who receive valsartan versus amlodipine, and extends this finding to a 'real-world' setting...

..The efficacy and safety of memantine in patients with moderate-to-severe Alzheimer's disease (AD) receiving stable doses of donepezil were recently demonstrated in a phase III trial. The cost-effectiveness of such therapy is unknown...

..Patients with hypertension often have other major risk factors for cardiovascular disease (CVD). Little is known, however, about the extent of risk-factor clustering in these patients and its importance in CVD risk and medical-care costs...

..Cost of neutropenic complications of myelosuppressive chemotherapy has been reported to be substantial. Prior research, however, has focused on initial hospitalization only and has failed to account for follow-on care...

..Although information concerning the attainment of goal blood pressure for patients commencing antihypertensive therapy is available from controlled trials, no studies have examined this issue in the context of typical clinical practice...

..In clinical practice, however, many patients receive shorter courses of therapy, even though the effectiveness of this regimen is unknown...

..Whether, and to what extent, this risk may vary across subgroups defined on the basis of important clinical characteristics has not been well characterized...

..Similar reductions were estimated to occur in influenza-related mortality and economic costs...

..Hospitalization accounted for the largest component of total medical care charges. CONCLUSIONS: Mortality and economic costs are high in patients with severe sepsis, during the period of acute illness as well as subsequently...

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..The aim of this study was to estimate the cost effectiveness of breast cancer screening with contrast-enhanced magnetic resonance imaging (MRI), with and without adjunctive x-ray mammography (XM), compared with XM alone in high-risk women...

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..Prospective data defining the clinical course in idiopathic pulmonary fibrosis (IPF) are sparse...