Leigh Anderson

Summary

Affiliation: Plasma Proteome Institute
Country: USA

Publications

  1. ncbi request reprint Mass spectrometric quantitation of peptides and proteins using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA)
    N Leigh Anderson
    Plasma Proteome Institute, PO Box 53450, Washington, DC 20009 3450, USA
    J Proteome Res 3:235-44. 2004
  2. doi request reprint The clinical plasma proteome: a survey of clinical assays for proteins in plasma and serum
    N Leigh Anderson
    Plasma Proteome Institute, Washington, DC 20009 3450, USA
    Clin Chem 56:177-85. 2010
  3. pmc A list of candidate cancer biomarkers for targeted proteomics
    Malu Polanski
    The Plasma Proteome Institute, P O Box 53450, Washington DC, 20009 3450, USA
    Biomark Insights 1:1-48. 2007
  4. doi request reprint Precision of heavy-light peptide ratios measured by maldi-tof mass spectrometry
    N Leigh Anderson
    Plasma Proteome Institute, Washington, DC, United States
    J Proteome Res 11:1868-78. 2012
  5. pmc SISCAPA peptide enrichment on magnetic beads using an in-line bead trap device
    N Leigh Anderson
    The Plasma Proteome Institute, Washington, D C 20009, USA
    Mol Cell Proteomics 8:995-1005. 2009
  6. pmc A human proteome detection and quantitation project
    N Leigh Anderson
    The Plasma Proteome Institute, Washington, D C 20009, USA
    Mol Cell Proteomics 8:883-6. 2009
  7. ncbi request reprint Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins
    Leigh Anderson
    The Plasma Proteome Institute, Washington, DC 20009 3450, USA
    Mol Cell Proteomics 5:573-88. 2006
  8. ncbi request reprint The roles of multiple proteomic platforms in a pipeline for new diagnostics
    N Leigh Anderson
    The Plasma Proteome Institute, Washington, D C 20009 3450, USA
    Mol Cell Proteomics 4:1441-4. 2005
  9. pmc Candidate-based proteomics in the search for biomarkers of cardiovascular disease
    Leigh Anderson
    Plasma Proteome Institute, Washington, DC, USA
    J Physiol 563:23-60. 2005
  10. ncbi request reprint The human plasma proteome: a nonredundant list developed by combination of four separate sources
    N Leigh Anderson
    The Plasma Proteome Institute, Washington DC 20009 3450, USA
    Mol Cell Proteomics 3:311-26. 2004

Collaborators

Detail Information

Publications22

  1. ncbi request reprint Mass spectrometric quantitation of peptides and proteins using Stable Isotope Standards and Capture by Anti-Peptide Antibodies (SISCAPA)
    N Leigh Anderson
    Plasma Proteome Institute, PO Box 53450, Washington, DC 20009 3450, USA
    J Proteome Res 3:235-44. 2004
    ..The method appears suitable for rapid generation of assays for defined proteins, and should find application in the validation of diagnostic protein panels in large sample sets...
  2. doi request reprint The clinical plasma proteome: a survey of clinical assays for proteins in plasma and serum
    N Leigh Anderson
    Plasma Proteome Institute, Washington, DC 20009 3450, USA
    Clin Chem 56:177-85. 2010
    ..This rate falls far short of that needed to support projected medical needs and indicates serious deficiencies in the protein biomarker pipeline, from which no proteomics-discovered analytes have yet emerged...
  3. pmc A list of candidate cancer biomarkers for targeted proteomics
    Malu Polanski
    The Plasma Proteome Institute, P O Box 53450, Washington DC, 20009 3450, USA
    Biomark Insights 1:1-48. 2007
    ..We propose that systematic collection and large-scale validation of candidate biomarkers would fill the gap currently existing between basic research and clinical use of advanced diagnostics...
  4. doi request reprint Precision of heavy-light peptide ratios measured by maldi-tof mass spectrometry
    N Leigh Anderson
    Plasma Proteome Institute, Washington, DC, United States
    J Proteome Res 11:1868-78. 2012
    ..The robustness and throughput of MALDI-TOF in comparison to conventional nano-LC-MS technology could enable currently impractical large-scale verification studies of protein biomarkers...
  5. pmc SISCAPA peptide enrichment on magnetic beads using an in-line bead trap device
    N Leigh Anderson
    The Plasma Proteome Institute, Washington, D C 20009, USA
    Mol Cell Proteomics 8:995-1005. 2009
    ..g. the magnetic beads), suggesting that substantial improvement in enrichment could be achieved by development of improved inert bead surfaces...
  6. pmc A human proteome detection and quantitation project
    N Leigh Anderson
    The Plasma Proteome Institute, Washington, D C 20009, USA
    Mol Cell Proteomics 8:883-6. 2009
    ....
  7. ncbi request reprint Quantitative mass spectrometric multiple reaction monitoring assays for major plasma proteins
    Leigh Anderson
    The Plasma Proteome Institute, Washington, DC 20009 3450, USA
    Mol Cell Proteomics 5:573-88. 2006
    ....
  8. ncbi request reprint The roles of multiple proteomic platforms in a pipeline for new diagnostics
    N Leigh Anderson
    The Plasma Proteome Institute, Washington, D C 20009 3450, USA
    Mol Cell Proteomics 4:1441-4. 2005
  9. pmc Candidate-based proteomics in the search for biomarkers of cardiovascular disease
    Leigh Anderson
    Plasma Proteome Institute, Washington, DC, USA
    J Physiol 563:23-60. 2005
    ..A set of 177 candidate biomarker proteins with reported associations to cardiovascular disease and stroke are presented as a starting point for such a 'directed proteomics' approach...
  10. ncbi request reprint The human plasma proteome: a nonredundant list developed by combination of four separate sources
    N Leigh Anderson
    The Plasma Proteome Institute, Washington DC 20009 3450, USA
    Mol Cell Proteomics 3:311-26. 2004
    ..The resulting nonredundant list confirms the presence of a number of interesting candidate marker proteins in plasma and serum...
  11. ncbi request reprint The human plasma proteome: history, character, and diagnostic prospects
    N Leigh Anderson
    Plasma Proteome Institute, Washington, DC 20009 3450, USA
    Mol Cell Proteomics 1:845-67. 2002
    ....
  12. ncbi request reprint An effective and rapid method for functional characterization of immunoadsorbents using POROS beads and flow cytometry
    N Leigh Anderson
    Plasma Proteome Institute, PO Box 53450, Washington, DC 20009 3450, USA
    J Proteome Res 3:228-34. 2004
    ....
  13. ncbi request reprint National Heart, Lung, And Blood Institute Clinical Proteomics Working Group report
    Christopher B Granger
    Duke University Medical Center, Box 3409, Durham, NC 27710, USA
    Circulation 109:1697-703. 2004
    ....
  14. doi request reprint High-abundance polypeptides of the human plasma proteome comprising the top 4 logs of polypeptide abundance
    Glen L Hortin
    Department of Laboratory Medicine, Clinical Center, National Institutes of Health, Bethesda, MD 20892 1508, USA
    Clin Chem 54:1608-16. 2008
    ..Plasma contains thousands of proteins, but a small number of these proteins comprise the majority of protein molecules and mass...
  15. ncbi request reprint Multi-component immunoaffinity subtraction chromatography: an innovative step towards a comprehensive survey of the human plasma proteome
    Rembert Pieper
    Large Scale Biology Corporation, Germantown, Maryland, USA
    Proteomics 3:422-32. 2003
    ..This facilitates automated chromatographic processing of plasma samples in high throughput, which is desirable in proteomic disease marker discovery projects...
  16. ncbi request reprint Therapeutic potential of the plasma proteome
    Julia Tait Lathrop
    Plasma Derivatives Department, Holland Laboratory for the Biomedical Sciences, American Red Cross, 15601 Crabbs Branch Way, Rockville, MD 20855, USA
    Curr Opin Mol Ther 5:250-7. 2003
    ..Emerging cell-based technologies are being applied to discover novel protein activities and identify epitope-specific antibodies that may have clinical promise...
  17. ncbi request reprint Proteomic analysis of rat soleus and tibialis anterior muscle following immobilization
    Robert J Isfort
    Research Division, Health Care Research Center, Procter and Gamble Pharmaceuticals, Mason, OH 45040 9317, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 769:323-32. 2002
    ..Together these data demonstrate that coordinated temporally regulated changes in the proteome occur during immobilization-induced atrophy in both slow twitch and fast twitch fiber type skeletal muscle...
  18. ncbi request reprint The human serum proteome: display of nearly 3700 chromatographically separated protein spots on two-dimensional electrophoresis gels and identification of 325 distinct proteins
    Rembert Pieper
    Large Scale Biology Corporation, 20451 Seneca Meadows Parkway, Germantown, MD 20876, USA
    Proteomics 3:1345-64. 2003
    ..Considering that our strategy allows highly parallel protein quantitation on 2-DE gels, it holds promise to accelerate the discovery of novel serum protein biomarkers...
  19. ncbi request reprint A reagent resource to identify proteins and peptides of interest for the cancer community: a workshop report
    Brian B Haab
    Van Andel Research Institute, Grand Rapids, Michigan 49503, USA
    Mol Cell Proteomics 5:1996-2007. 2006
    ..This workshop report explores various approaches to develop a framework that will most effectively fulfill the needs of the NCI and the cancer research community...
  20. ncbi request reprint Proteomics: from basic research to diagnostic application. A review of requirements & needs
    Frank Vitzthum
    Dade Behring Marburg GmbH, Emil von Behring Strasse 76, PO Box 1149, 35041 Marburg, Germany
    J Proteome Res 4:1086-97. 2005
    ..This helps to generate acceptance and assists the implementation process. On the basis of IVD requirements and needs, we outline potential implications for clinical proteomics focused on applied research activities...
  21. ncbi request reprint Proteomic analysis of rat soleus muscle undergoing hindlimb suspension-induced atrophy and reweighting hypertrophy
    Robert J Isfort
    Research Division, Procter and Gamble Pharmaceuticals, Mason, OH 45040 9317, USA
    Proteomics 2:543-50. 2002
    ..Together these data demonstrate that coordinated temporally regulated changes in the skeletal muscle proteome occur during disuse-induced soleus muscle atrophy and reweighting hypertrophy...