Chad E Bigelow

Summary

Affiliation: Physical Sciences
Country: USA

Publications

  1. ncbi request reprint Line-scanning laser ophthalmoscope
    Daniel X Hammer
    Physical Sciences Incorporated, 20 New England Business Center, Andover, Massachusetts 01810, USA
    J Biomed Opt 11:041126. 2006
  2. ncbi request reprint Confocal fluorescence polarization microscopy in turbid media: effects of scattering-induced depolarization
    Chad E Bigelow
    Institute of Optics, University of Rochester, Rochester, New York 14627, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2932-43. 2006
  3. ncbi request reprint Fluorescence anisotropy imaging reveals localization of meso-tetrahydroxyphenyl chlorin in the nuclear envelope
    Thomas H Foster
    Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
    Photochem Photobiol 81:1544-7. 2005
  4. pmc Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography study
    Daniel X Hammer
    Physical Sciences Inc, 20 New England Business Center, Andover, MA 01810, USA
    Invest Ophthalmol Vis Sci 49:2061-70. 2008
  5. pmc Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling
    Jeremy D Wilson
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14642, USA
    Biophys J 88:2929-38. 2005
  6. ncbi request reprint Imaging enzyme activity with polarization-sensitive confocal fluorescence microscopy
    Chad E Bigelow
    The Institute of Optics, University of Rochester, NY 14642, USA
    J Microsc 215:24-33. 2004
  7. pmc Susceptibility of Candida species to photodynamic effects of photofrin
    Joseph M Bliss
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 48:2000-6. 2004
  8. pmc Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    Am J Pathol 169:1739-52. 2006
  9. ncbi request reprint Confocal fluorescence spectroscopy and anisotropy imaging system
    Chad E Bigelow
    University of Rochester, Department of Radiology and the Institute of Optics, 601 Elmwood Avenue, Box 648, Rochester, New York 14642, USA
    Opt Lett 28:695-7. 2003
  10. ncbi request reprint Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging
    Chad E Bigelow
    Physical Sciences Inc, Andover, MA 01810, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1327-36. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Line-scanning laser ophthalmoscope
    Daniel X Hammer
    Physical Sciences Incorporated, 20 New England Business Center, Andover, Massachusetts 01810, USA
    J Biomed Opt 11:041126. 2006
    ....
  2. ncbi request reprint Confocal fluorescence polarization microscopy in turbid media: effects of scattering-induced depolarization
    Chad E Bigelow
    Institute of Optics, University of Rochester, Rochester, New York 14627, USA
    J Opt Soc Am A Opt Image Sci Vis 23:2932-43. 2006
    ..From this detailed analysis and comparison of experiment with simulation, we determine that fluorescence polarization is maintained to depths at which meaningful intensity images can be acquired...
  3. ncbi request reprint Fluorescence anisotropy imaging reveals localization of meso-tetrahydroxyphenyl chlorin in the nuclear envelope
    Thomas H Foster
    Department of Imaging Sciences, University of Rochester, Rochester, NY 14642, USA
    Photochem Photobiol 81:1544-7. 2005
    ..12. The change from a positive intrinsic anisotropy in homogeneous solution to a negative value in cells suggests an environmentally induced change in the relative orientations of the absorption and emission dipole moments...
  4. pmc Foveal fine structure in retinopathy of prematurity: an adaptive optics Fourier domain optical coherence tomography study
    Daniel X Hammer
    Physical Sciences Inc, 20 New England Business Center, Andover, MA 01810, USA
    Invest Ophthalmol Vis Sci 49:2061-70. 2008
    ..To describe the fine structure of the fovea in subjects with a history of mild retinopathy of prematurity (ROP) using adaptive optics-Fourier domain optical coherence tomography (AO-FDOCT)...
  5. pmc Light scattering from intact cells reports oxidative-stress-induced mitochondrial swelling
    Jeremy D Wilson
    Department of Physics and Astronomy, University of Rochester, Rochester, New York 14642, USA
    Biophys J 88:2929-38. 2005
    ..Thus, in this system, angularly resolved light scattering reports oxidative-stress-induced changes in mitochondrial morphology...
  6. ncbi request reprint Imaging enzyme activity with polarization-sensitive confocal fluorescence microscopy
    Chad E Bigelow
    The Institute of Optics, University of Rochester, NY 14642, USA
    J Microsc 215:24-33. 2004
    ..These results suggest wide applicability of the technique in biological systems when used in conjunction with appropriately designed constructs...
  7. pmc Susceptibility of Candida species to photodynamic effects of photofrin
    Joseph M Bliss
    Department of Pediatrics, University of Rochester School of Medicine and Dentistry, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA
    Antimicrob Agents Chemother 48:2000-6. 2004
    ..The results indicate that photodynamic therapy may be a useful adjunct or alternative to current anti-Candida therapeutic modalities, particularly for superficial infections on surfaces amenable to illumination...
  8. pmc Preferential attachment of peritoneal tumor metastases to omental immune aggregates and possible role of a unique vascular microenvironment in metastatic survival and growth
    Scott A Gerber
    Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA
    Am J Pathol 169:1739-52. 2006
    ..These sites provide metastatic cells with a microenvironment highly conducive to survival and subsequent growth...
  9. ncbi request reprint Confocal fluorescence spectroscopy and anisotropy imaging system
    Chad E Bigelow
    University of Rochester, Department of Radiology and the Institute of Optics, 601 Elmwood Avenue, Box 648, Rochester, New York 14642, USA
    Opt Lett 28:695-7. 2003
    ..The quality of the axial sectioning that is achieved in the confocal fluorescence spectroscopy mode is demonstrated experimentally, and examples of polarization-sensitive fluorescence imaging are demonstrated in tumor cell monolayers...
  10. ncbi request reprint Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging
    Chad E Bigelow
    Physical Sciences Inc, Andover, MA 01810, USA
    J Opt Soc Am A Opt Image Sci Vis 24:1327-36. 2007
    ..In human volunteer testing, we observed up to an 8 dB increase in OCT signal and a corresponding lateral resolution of <10 microm as a result of AO correction...