Lindon H Young

Summary

Affiliation: Philadelphia College of Osteopathic Medicine
Country: USA

Publications

  1. ncbi Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion
    Ellen E Peterman
    Department of Pathology, Philadelphia College of Osteopathic Medicine Philadelphia, Pennsylvania 19131-1694, USA
    J Cardiovasc Pharmacol 43:645-56. 2004
  2. ncbi Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury
    Lindon H Young
    Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131 1694, USA
    Cardiovasc Drug Rev 23:255-72. 2005
  3. ncbi Protein kinase C betaII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury
    Didi Omiyi
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA
    J Pharmacol Exp Ther 314:542-51. 2005
  4. ncbi The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R)
    Kerry Anne A Perkins
    Department of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131 1694, USA
    Naunyn Schmiedebergs Arch Pharmacol 385:27-38. 2012
  5. ncbi Mechanisms related to the cardioprotective effects of protein kinase C epsilon (PKC epsilon) peptide activator or inhibitor in rat ischemia/reperfusion injury
    Jane Chun wen Teng
    Biomedical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131 1694, USA
    Naunyn Schmiedebergs Arch Pharmacol 378:1-15. 2008
  6. ncbi The role of tetrahydrobiopterin and dihydrobiopterin in ischemia/reperfusion injury when given at reperfusion
    Qian Chen
    Department of Pathology, Microbiology and Immunology and Forensic Medicine, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131 1694, USA
    Adv Pharmacol Sci 2010:963914. 2010
  7. ncbi Protein kinase C-zeta inhibition exerts cardioprotective effects in ischemia-reperfusion injury
    Aisha Phillipson
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA 19131-1694, USA
    Am J Physiol Heart Circ Physiol 289:H898-907. 2005
  8. ncbi Attenuation of neutrophil-mediated myocardial ischemia-reperfusion injury by a calpain inhibitor
    Yasuhiko Ikeda
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Heart Circ Physiol 282:H1421-6. 2002
  9. ncbi Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium in normocholesterolemic rats
    Yasuhiko Ikeda
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Cardiovasc Pharmacol 41:649-56. 2003

Research Grants

  1. PKC isoform inhibition in cardiac ischemia/reperfusion
    Lindon Young; Fiscal Year: 2004

Collaborators

  • Yasuhiko Ikeda
  • Margaret T Weis
  • Qian Chen
  • Jane Chun wen Teng
  • Samuel Krass
  • Christopher Zambrano
  • Helen Kay
  • Jovan S Adams
  • Didi Omiyi
  • Margaret Harvey
  • Kerry Anne A Perkins
  • Philip Taormina
  • Ellen E Peterman
  • Sailesh Pershad
  • Sloane McGraw
  • Jeffrey Emrich
  • Aisha Phillipson
  • Richard J Brue
  • Norrell Atkinson
  • Brandon Bell
  • Michael Iyamu
  • Catherine Prince
  • Katrina Elio
  • Kerry Anne Perkins
  • Elizabeth Eun Jung Kim
  • Adrian Bell
  • Giuseppe Guglielmello
  • Christopher Grilli
  • Uchenna Chukwu

Detail Information

Publications9

  1. ncbi Gö 6983 exerts cardioprotective effects in myocardial ischemia/reperfusion
    Ellen E Peterman
    Department of Pathology, Philadelphia College of Osteopathic Medicine Philadelphia, Pennsylvania 19131-1694, USA
    J Cardiovasc Pharmacol 43:645-56. 2004
    ..01). In the presence of PMNs, Gö 6983 attenuated post-I/R cardiac contractile dysfunction, which may be related in part to decreased superoxide production...
  2. ncbi Gö 6983: a fast acting protein kinase C inhibitor that attenuates myocardial ischemia/reperfusion injury
    Lindon H Young
    Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131 1694, USA
    Cardiovasc Drug Rev 23:255-72. 2005
    ..However, given the broad-spectrum action of Gö 6983, careful titration of the dose regimen would be recommended to ensure a successful outcome in the setting of organ transplantation and/or cerebral ischemia...
  3. ncbi Protein kinase C betaII peptide inhibitor exerts cardioprotective effects in rat cardiac ischemia/reperfusion injury
    Didi Omiyi
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA
    J Pharmacol Exp Ther 314:542-51. 2005
    ..01). These results suggest that the PKC betaII peptide inhibitor attenuates PMN-induced post-I/R cardiac contractile dysfunction by increasing endothelial NO release and by inhibiting superoxide release from PMNs...
  4. ncbi The effects of modulating eNOS activity and coupling in ischemia/reperfusion (I/R)
    Kerry Anne A Perkins
    Department of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131 1694, USA
    Naunyn Schmiedebergs Arch Pharmacol 385:27-38. 2012
    ....
  5. ncbi Mechanisms related to the cardioprotective effects of protein kinase C epsilon (PKC epsilon) peptide activator or inhibitor in rat ischemia/reperfusion injury
    Jane Chun wen Teng
    Biomedical Sciences, Philadelphia College of Osteopathic Medicine, Philadelphia, PA 19131 1694, USA
    Naunyn Schmiedebergs Arch Pharmacol 378:1-15. 2008
    ..By contrast, the cardioprotective effects of PKC epsilon activator PT may be mediated by enhancing vascular endothelial NO release before ischemia...
  6. ncbi The role of tetrahydrobiopterin and dihydrobiopterin in ischemia/reperfusion injury when given at reperfusion
    Qian Chen
    Department of Pathology, Microbiology and Immunology and Forensic Medicine, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131 1694, USA
    Adv Pharmacol Sci 2010:963914. 2010
    ..In conclusion, these results suggest that promoting eNOS coupling to produce NO and decrease H(2)O(2) may be a key mechanism to restore postreperfused organ function during early reperfusion...
  7. ncbi Protein kinase C-zeta inhibition exerts cardioprotective effects in ischemia-reperfusion injury
    Aisha Phillipson
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA 19131-1694, USA
    Am J Physiol Heart Circ Physiol 289:H898-907. 2005
    ....
  8. ncbi Attenuation of neutrophil-mediated myocardial ischemia-reperfusion injury by a calpain inhibitor
    Yasuhiko Ikeda
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Am J Physiol Heart Circ Physiol 282:H1421-6. 2002
    ..01). These results provide evidence that Z-Leu-Leu-CHO significantly attenuates PMN-mediated I/R injury in the isolated perfused rat heart to a significant extent via downregulation of P-selectin expression...
  9. ncbi Rosuvastatin, a new HMG-CoA reductase inhibitor, protects ischemic reperfused myocardium in normocholesterolemic rats
    Yasuhiko Ikeda
    Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    J Cardiovasc Pharmacol 41:649-56. 2003
    ..These results provide evidence that rosuvastatin significantly attenuates PMN-induced cardiac contractile dysfunction in the isolated perfused rat heart...

Research Grants2

  1. PKC isoform inhibition in cardiac ischemia/reperfusion
    Lindon Young; Fiscal Year: 2004
    ..abstract_text> ..