Brian J Balin

Summary

Affiliation: Philadelphia College of Osteopathic Medicine
Country: USA

Publications

  1. pmc Effect of age and vaccination on extent and spread of Chlamydia pzneumoniae infection in C57BL/6 mice
    Taylor Eddens
    Department of Pathology, Microbiology, and Immunology, the Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA, 19131, USA
    Immun Ageing 9:11. 2012
  2. ncbi request reprint Role of infection in Alzheimer's disease
    B J Balin
    Department of Pathology Microbiology, Philadelphia College of Osteopathic Medicine, Pennsylvania 19131, USA
    J Am Osteopath Assoc 101:S1-6. 2001
  3. ncbi request reprint Chlamydophila pneumoniae and the etiology of late-onset Alzheimer's disease
    Brian J Balin
    Department of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia PA 19131, USA
    J Alzheimers Dis 13:371-80. 2008
  4. pmc Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain
    Christine J Hammond
    Pathology Microbiology Immunology and Forensic Medicine Department, Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, Pennsylvania, USA
    BMC Neurosci 11:121. 2010
  5. ncbi request reprint Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice
    C Scott Little
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA
    Neurobiol Aging 25:419-29. 2004
  6. pmc Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae
    Denah M Appelt
    Department of Neuroscience, Physiology and Pharmacology, Philadelphia College of Osteopathic Medicine, Philadelphia, USA
    BMC Neurosci 9:13. 2008
  7. pmc Age alterations in extent and severity of experimental intranasal infection with Chlamydophila pneumoniae in BALB/c mice
    C Scott Little
    Department of Pathology, Microbiology, and Immunology, the Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA 19131, USA
    Infect Immun 73:1723-34. 2005
  8. ncbi request reprint Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells
    Angela MacIntyre
    Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA 19131, USA
    FEMS Microbiol Lett 217:167-72. 2002
  9. pmc NLRP3 inflammasome is a target for development of broad-spectrum anti-infective drugs
    James D Thacker
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Antimicrob Agents Chemother 56:1921-30. 2012
  10. ncbi request reprint Modern care for patients with Alzheimer disease: rationale for early intervention
    Katherine E Galluzzi
    Department of Geriatrics, Philadelphia College of Osteopathic Medicine, Rowland Hall, Suite 315, Philadelphia, Pennsylvania 19131 1633, USA
    J Am Osteopath Assoc 110:S37-42. 2010

Collaborators

  • Denah M Appelt
  • James D Thacker
  • C Scott Little
  • Christine J Hammond
  • Taylor Eddens
  • Katherine E Galluzzi
  • Angela MacIntyre
  • Kerin L Fresa-Dillon
  • Amanda Steinberger
  • Sarah Beaudoin
  • Benjamin Wizel
  • Dawn Shell
  • Raymond J Howanski
  • Loretta R Hallock
  • Robert M Fogel
  • Jason Litsky
  • Richard Lin
  • Andrew Bowe

Detail Information

Publications11

  1. pmc Effect of age and vaccination on extent and spread of Chlamydia pzneumoniae infection in C57BL/6 mice
    Taylor Eddens
    Department of Pathology, Microbiology, and Immunology, the Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA, 19131, USA
    Immun Ageing 9:11. 2012
    ..abstract:..
  2. ncbi request reprint Role of infection in Alzheimer's disease
    B J Balin
    Department of Pathology Microbiology, Philadelphia College of Osteopathic Medicine, Pennsylvania 19131, USA
    J Am Osteopath Assoc 101:S1-6. 2001
    ..pneumoniae is found in high frequency in glial cells in areas of neuropathology within the brains of patients with AD. Based on our evidence, nervous system infection with C. pneumoniae should be considered a risk factor for sporadic AD...
  3. ncbi request reprint Chlamydophila pneumoniae and the etiology of late-onset Alzheimer's disease
    Brian J Balin
    Department of Pathology, Microbiology, Immunology and Forensic Medicine, Philadelphia PA 19131, USA
    J Alzheimers Dis 13:371-80. 2008
    ..This review focuses specifically on infection with Chlamydophila (Chlamydia) pneumoniae in LOAD and how this infection may function as a "trigger or initiator" in the pathogenesis of this disease...
  4. pmc Immunohistological detection of Chlamydia pneumoniae in the Alzheimer's disease brain
    Christine J Hammond
    Pathology Microbiology Immunology and Forensic Medicine Department, Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, Pennsylvania, USA
    BMC Neurosci 11:121. 2010
    ..pneumoniae antibodies to determine whether C. pneumoniae was present in areas typically associated with AD neuropathology from 5 AD and 5 non-AD control brains...
  5. ncbi request reprint Chlamydia pneumoniae induces Alzheimer-like amyloid plaques in brains of BALB/c mice
    C Scott Little
    Department of Pathology, Microbiology, and Immunology, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA 19131, USA
    Neurobiol Aging 25:419-29. 2004
    ..pneumoniae may be a useful model for furthering our understanding of mechanisms, linked to infection, involved in the initiation of the pathogenesis of sporadic AD...
  6. pmc Inhibition of apoptosis in neuronal cells infected with Chlamydophila (Chlamydia) pneumoniae
    Denah M Appelt
    Department of Neuroscience, Physiology and Pharmacology, Philadelphia College of Osteopathic Medicine, Philadelphia, USA
    BMC Neurosci 9:13. 2008
    ..Chronic and/or persistent infection of neuronal cells with C. pneumoniae in the AD brain may affect apoptosis in cells containing chlamydial inclusions...
  7. pmc Age alterations in extent and severity of experimental intranasal infection with Chlamydophila pneumoniae in BALB/c mice
    C Scott Little
    Department of Pathology, Microbiology, and Immunology, the Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA 19131, USA
    Infect Immun 73:1723-34. 2005
    ..pneumoniae titers in old animals than in young animals. Our results suggest that infection with C. pneumoniae may be more severe in old animals...
  8. ncbi request reprint Chlamydia pneumoniae infection alters the junctional complex proteins of human brain microvascular endothelial cells
    Angela MacIntyre
    Department of Biomedical Sciences, Philadelphia College of Osteopathic Medicine, 4170 City Ave, Philadelphia, PA 19131, USA
    FEMS Microbiol Lett 217:167-72. 2002
    ..These events may underlie a mechanism for the regulation of paracellular permeability while maintaining barrier integrity during C. pneumoniae infection associated with neuropathologies such as MS and AD...
  9. pmc NLRP3 inflammasome is a target for development of broad-spectrum anti-infective drugs
    James D Thacker
    Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA
    Antimicrob Agents Chemother 56:1921-30. 2012
    ....
  10. ncbi request reprint Modern care for patients with Alzheimer disease: rationale for early intervention
    Katherine E Galluzzi
    Department of Geriatrics, Philadelphia College of Osteopathic Medicine, Rowland Hall, Suite 315, Philadelphia, Pennsylvania 19131 1633, USA
    J Am Osteopath Assoc 110:S37-42. 2010
    ..The authors briefly examine the rationale and methods for screening patients for early indications of the onset of Alzheimer disease. They also describe current and potential treatments for patients with this disease...
  11. doi request reprint Etiology and pathogenesis of late-onset Alzheimer's disease
    Brian J Balin
    Department of Pathology, Microbiology, Immunology, and Forensic Medicine, Philadelphia College of Osteopathic Medicine, 4170 City Avenue, Philadelphia, PA, 1913, USA
    Curr Allergy Asthma Rep 14:417. 2014
    ..In the discussions included here, we reference relevant clinical and basic science literature underlying research into disease etiology and pathogenesis, and we highlight current reviews on the various topics addressed. ..