Junxing Shi

Summary

Affiliation: Pharmasset Inc
Country: USA

Publications

  1. ncbi request reprint Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system
    Junxing Shi
    Pharmasset, Inc, 1860 Montreal Rd, Tucker, GA 30084, USA
    Bioorg Med Chem 13:1641-52. 2005
  2. ncbi request reprint N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity
    Junxing Shi
    Pharmasset, Inc, Tucker, GA, USA
    Antivir Chem Chemother 14:81-90. 2003
  3. ncbi request reprint Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides
    Junxing Shi
    Pharmasset, Inc, Tucker, GA, USA
    Nucleosides Nucleotides Nucleic Acids 24:875-9. 2005
  4. ncbi request reprint N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus
    Jinfa Du
    Pharmasset, Inc, 1860 Montreal Road, Tucker, GA 30084, USA
    Nucleosides Nucleotides Nucleic Acids 24:1209-14. 2005
  5. pmc Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine
    Lieven J Stuyver
    Pharmasset, Inc, Tucker, Georgia 30084, USA
    Antimicrob Agents Chemother 48:651-4. 2004
  6. doi request reprint An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase
    Peiyuan Wang
    Pharmasset, Inc, 303A College Road E, Princeton, New Jersey 08540, USA
    J Org Chem 74:6819-24. 2009
  7. ncbi request reprint Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture
    Laurent Hollecker
    Pharmasset Inc, Tucker, GA, USA
    Antivir Chem Chemother 15:43-55. 2004
  8. pmc Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates
    Junxing Shi
    RFS Pharma, LLC, 1860 Montreal Road, Tucker, GA 30084, USA
    Bioorg Med Chem Lett 21:7094-8. 2011
  9. ncbi request reprint Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides
    S Balakrishna Pai
    Veterans Affairs Medical Center, Decatur, GA, USA
    Antivir Chem Chemother 16:183-92. 2005
  10. doi request reprint Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors
    Junxing Shi
    RFS Pharma, LLC, 1860 Montreal Road, Tucker, GA 30084, USA
    Bioorg Med Chem Lett 22:3488-91. 2012

Collaborators

Detail Information

Publications19

  1. ncbi request reprint Synthesis and anti-viral activity of a series of d- and l-2'-deoxy-2'-fluororibonucleosides in the subgenomic HCV replicon system
    Junxing Shi
    Pharmasset, Inc, 1860 Montreal Rd, Tucker, GA 30084, USA
    Bioorg Med Chem 13:1641-52. 2005
    ..All the l-forms of the analogues were devoid of anti-HCV activity. None of the compounds showed anti-BVDV activity, suggesting that the BVDV system cannot always predict anti-HCV activity...
  2. ncbi request reprint N4-acyl-modified D-2',3'-dideoxy-5-fluorocytidine nucleoside analogues with improved antiviral activity
    Junxing Shi
    Pharmasset, Inc, Tucker, GA, USA
    Antivir Chem Chemother 14:81-90. 2003
    ....
  3. ncbi request reprint Synthesis and in vitro anti-HCV activity of beta-D- and 1-2'-deoxy-2'-fluororibonucleosides
    Junxing Shi
    Pharmasset, Inc, Tucker, GA, USA
    Nucleosides Nucleotides Nucleic Acids 24:875-9. 2005
    ..All the L-forms of the analogues were devoid of anti-HCV activity. None of the compounds showed anti-BVDV activity, suggesting that the BVDV system cannot reliably predict anti-HCV activity in vitro...
  4. ncbi request reprint N4-hydroxycytosine dioxolane nucleosides and their activity against hepatitis B virus
    Jinfa Du
    Pharmasset, Inc, 1860 Montreal Road, Tucker, GA 30084, USA
    Nucleosides Nucleotides Nucleic Acids 24:1209-14. 2005
    ..Novel racemic, D- and L-beta-dioxolane N4-hydroxycytosine nucleosides have been synthesized and evaluated for their activity against hepatitis B virus. None of the synthesized nucleosides demonstrated selective anti-HBV activity...
  5. pmc Inhibition of the subgenomic hepatitis C virus replicon in huh-7 cells by 2'-deoxy-2'-fluorocytidine
    Lieven J Stuyver
    Pharmasset, Inc, Tucker, Georgia 30084, USA
    Antimicrob Agents Chemother 48:651-4. 2004
    ..Dynamic profiling of cell growth in an antiviral assay showed that FdC caused cytostasis due to an S-phase arrest. These observations demonstrate that FdC treatment is affecting both a viral target and a cellular target...
  6. doi request reprint An efficient and diastereoselective synthesis of PSI-6130: a clinically efficacious inhibitor of HCV NS5B polymerase
    Peiyuan Wang
    Pharmasset, Inc, 303A College Road E, Princeton, New Jersey 08540, USA
    J Org Chem 74:6819-24. 2009
    ..Scale-limiting chromatographic purifications were eliminated through the use of crystalline intermediates...
  7. ncbi request reprint Synthesis of beta-enantiomers of N4-hydroxy-3'-deoxypyrimidine nucleosides and their evaluation against bovine viral diarrhoea virus and hepatitis C virus in cell culture
    Laurent Hollecker
    Pharmasset Inc, Tucker, GA, USA
    Antivir Chem Chemother 15:43-55. 2004
    ..In conclusion, none of the newly synthesized derivatives exhibited enhanced antiviral activity compared to the parent nucleoside NHC...
  8. pmc Synthesis and antiviral activity of 2'-deoxy-2'-fluoro-2'-C-methyl-7-deazapurine nucleosides, their phosphoramidate prodrugs and 5'-triphosphates
    Junxing Shi
    RFS Pharma, LLC, 1860 Montreal Road, Tucker, GA 30084, USA
    Bioorg Med Chem Lett 21:7094-8. 2011
    ..71±0.25 μM; EC(90)=9.5±3.3 μM) with no observed cytotoxicity up to 100 μM in four different cell lines...
  9. ncbi request reprint Characterization of hepatitis B virus inhibition by novel 2'-fluoro-2',3'-unsaturated beta-D- and L-nucleosides
    S Balakrishna Pai
    Veterans Affairs Medical Center, Decatur, GA, USA
    Antivir Chem Chemother 16:183-92. 2005
    ..This class of nucleosides, which exhibit potent antiviral activity and a favourable safety profile, have potential for the treatment of HBV infections and warrant further development...
  10. doi request reprint Synthesis and biological evaluation of new potent and selective HCV NS5A inhibitors
    Junxing Shi
    RFS Pharma, LLC, 1860 Montreal Road, Tucker, GA 30084, USA
    Bioorg Med Chem Lett 22:3488-91. 2012
    ..This triphenyl analog warrants further preclinical evaluation as an anti-HCV agent...
  11. pmc Ribonucleoside analogue that blocks replication of bovine viral diarrhea and hepatitis C viruses in culture
    Lieven J Stuyver
    Pharmasset Inc, Tucker, Georgia 30084, USA
    Antimicrob Agents Chemother 47:244-54. 2003
    ....
  12. ncbi request reprint Unusual olefin formation by PhSe-F trans-elimination
    Jinfa Du
    Pharmasset, Inc, Tucker, Georgia 30084, USA
    Nucleosides Nucleotides Nucleic Acids 24:1289-92. 2005
    ..A new approach to the synthesis of 2',3'-didehydro-2',3-dideoxynucleosides was described in excellent yield through unusual olefin formation by PhSe-F trans-elimination...
  13. ncbi request reprint Synthesis of 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides
    Jinfa Du
    Pharmasset Inc, 1860 Montreal Road, Tucker, GA 30084, USA
    Bioorg Med Chem Lett 14:1243-5. 2004
    ..Novel racemic 5'-C-methyl-1',3'-dioxolan-4'-yl nucleosides were synthesized from the key intermediate, 2-benzoyloxymethyl-4-oxo-5-C-methyl-1,3-dioxolane, which was prepared from racemic lactic acid...
  14. ncbi request reprint Insights into the molecular mechanism of inhibition and drug resistance for HIV-1 RT with carbovir triphosphate
    Adrian S Ray
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, Connecticut 06520 8066, USA
    Biochemistry 41:5150-62. 2002
    ..This compound shows promise as a potent antiviral especially with the drug resistant M184V HIV-1 RT that is so often encountered in a clinical setting...
  15. ncbi request reprint 2('),3(')-didehydro-2('),3(')-dideoxynucleosides are degraded to furfuryl alcohol under acidic conditions
    Junxing Shi
    Department of Pharmacology, Yale University School of Medicine, New Haven, CT 06520 8066, USA
    Bioorg Med Chem Lett 14:2159-62. 2004
    ....
  16. ncbi request reprint Probing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase
    Adrian S Ray
    Department of Pharmacology, Yale University School of Medicine, New Haven, Conn, USA
    Antivir Chem Chemother 14:115-25. 2003
    ....
  17. ncbi request reprint Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio)acyclouridine, a uridine phosphorylase inhibitor
    Omar N Al Safarjalani
    Department of Pharmacology and Toxicology, Comprehensive Cancer Center, Center for AIDS Research, University of Alabama at Birmingham, Birmingham, AL 35294, USA
    Cancer Chemother Pharmacol 58:692-8. 2006
    ..PTAU is a potent and specific inhibitor of uridine phosphorylase (UrdPase, EC 2.4.2.3), the enzyme responsible for uridine catabolism...
  18. pmc Pharmacokinetics of the antiviral agent beta-D-2'-deoxy-2'-fluoro-2'-C-methylcytidine in rhesus monkeys
    Ghazia Asif
    Veterans Affairs Medical Center, Medical Research 151H, Decatur, GA 30033, USA
    Antimicrob Agents Chemother 51:2877-82. 2007
    ..Further studies are warranted to improve the oral bioavailability and reduce the deamination of PSI-6130 in order to explore the potential of this drug for the treatment of HCV-infected individuals...
  19. ncbi request reprint Interactions of enantiomers of 2',3'-didehydro-2',3'-dideoxy-fluorocytidine with wild type and M184V mutant HIV-1 reverse transcriptase
    Adrian S Ray
    Department of Pharmacology, Yale University School of Medicine, 333 Cedar Street, New Haven, CT 06520 8066, USA
    Antiviral Res 56:189-205. 2002
    ....