Tao Guo

Summary

Affiliation: Pharmacopeia Drug Discovery
Country: USA

Publications

  1. ncbi request reprint Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors
    Tao Guo
    Pharmacopeia Drug Discovery, Inc, P O Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 17:3010-3. 2007
  2. ncbi request reprint Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists
    Tao Guo
    Pharmacopeia Drug Discovery Inc, PO Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 17:1718-21. 2007
  3. ncbi request reprint Development of BACE1 inhibitors for Alzheimer's disease
    Tao Guo
    Pharmacopeia Drug Discovery, Inc, Box 5350, Princeton, NJ 08543 5350, USA
    Curr Med Chem 13:1811-29. 2006
  4. ncbi request reprint Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis
    Tao Guo
    Pharmacopeia Drug Discovery, Inc, P O Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 15:3696-700. 2005
  5. ncbi request reprint Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis
    Tao Guo
    Pharmacopeia, Inc, PO Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 14:1717-20. 2004
  6. ncbi request reprint Discovery and SAR of 4-amino-2-biarylbutylurea MCH 1 receptor antagonists through solid-phase parallel synthesis
    Tao Guo
    Pharmacopeia Drug Discovery, Inc, P O Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 15:3691-5. 2005
  7. ncbi request reprint Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis
    Tao Guo
    Pharmacopeia, Inc, PO Box 5350, Princeton, NJ 08543 5350
    Bioorg Med Chem Lett 14:1713-6. 2004
  8. ncbi request reprint Privileged structure-based combinatorial libraries targeting G protein-coupled receptors
    Tao Guo
    Pharmacopeia, Inc, Princeton, NJ 08543, USA
    Assay Drug Dev Technol 1:579-92. 2003
  9. ncbi request reprint Preparation of encoded combinatorial libraries for drug discovery
    Tao Guo
    Pharmacopeia Inc, Princeton, NJ, USA
    Methods Mol Biol 201:23-39. 2002
  10. ncbi request reprint 2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors
    Koc Kan Ho
    Pharmacopeia, Inc, PO Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 14:545-8. 2004

Detail Information

Publications12

  1. ncbi request reprint Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors
    Tao Guo
    Pharmacopeia Drug Discovery, Inc, P O Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 17:3010-3. 2007
    ..In this paper, the design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors are described...
  2. ncbi request reprint Discovery of tetralin ureas as potent melanin concentrating hormone 1 receptor antagonists
    Tao Guo
    Pharmacopeia Drug Discovery Inc, PO Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 17:1718-21. 2007
    ..As such, MCH1R antagonists are believed to have potential as possible treatments for obesity. The discovery of a novel class of tetralin ureas as potent MCH1R antagonists is described herein...
  3. ncbi request reprint Development of BACE1 inhibitors for Alzheimer's disease
    Tao Guo
    Pharmacopeia Drug Discovery, Inc, Box 5350, Princeton, NJ 08543 5350, USA
    Curr Med Chem 13:1811-29. 2006
    ..This review focuses on recent disclosures of BACE1 inhibitors in the patent and scientific literature, covering the period from approximately May 2004 to November 2005...
  4. ncbi request reprint Discovery and SAR of biaryl piperidine MCH1 receptor antagonists through solid-phase encoded combinatorial synthesis
    Tao Guo
    Pharmacopeia Drug Discovery, Inc, P O Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 15:3696-700. 2005
    ..Screening of this library resulted in the discovery of high-nanomolar biaryl piperidine-based MCH1 receptor antagonists. Follow-up optimization using a parallel synthesis provided potent, single digit nanomolar antagonists...
  5. ncbi request reprint Small molecule biaryl FSH receptor agonists. Part 2: Lead optimization via parallel synthesis
    Tao Guo
    Pharmacopeia, Inc, PO Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 14:1717-20. 2004
    ..These libraries were prepared via solid-phase parallel synthesis using a cyclization-release method...
  6. ncbi request reprint Discovery and SAR of 4-amino-2-biarylbutylurea MCH 1 receptor antagonists through solid-phase parallel synthesis
    Tao Guo
    Pharmacopeia Drug Discovery, Inc, P O Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 15:3691-5. 2005
    ....
  7. ncbi request reprint Small molecule biaryl FSH receptor agonists. Part 1: Lead discovery via encoded combinatorial synthesis
    Tao Guo
    Pharmacopeia, Inc, PO Box 5350, Princeton, NJ 08543 5350
    Bioorg Med Chem Lett 14:1713-6. 2004
    ..9 microM), based on which a focused combinatorial library with a total of 31372 compounds was designed, synthesized, and screened to reveal 72 novel biaryl FSH receptor agonists such as 8a-c as well as a unique combinatorial SAR...
  8. ncbi request reprint Privileged structure-based combinatorial libraries targeting G protein-coupled receptors
    Tao Guo
    Pharmacopeia, Inc, Princeton, NJ 08543, USA
    Assay Drug Dev Technol 1:579-92. 2003
    ....
  9. ncbi request reprint Preparation of encoded combinatorial libraries for drug discovery
    Tao Guo
    Pharmacopeia Inc, Princeton, NJ, USA
    Methods Mol Biol 201:23-39. 2002
  10. ncbi request reprint 2-(Aminomethyl)-benzamide-based glycine transporter type-2 inhibitors
    Koc Kan Ho
    Pharmacopeia, Inc, PO Box 5350, Princeton, NJ 08543 5350, USA
    Bioorg Med Chem Lett 14:545-8. 2004
    ..Structure-activity studies on benzamide 1 obtained from library screening led to the discovery of a novel series of potent and selective glycine transporter type-2 inhibitors...
  11. ncbi request reprint Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes
    Tao Guo
    Department of Physiology and Cardiovascular Institute, Loyola University Chicago, Stritch School of Medicine, Maywood, IL 60153, USA
    Circ Res 99:398-406. 2006
    ..Moreover, this may explain the enhanced SR diastolic Ca2+ leak and certain triggered arrhythmias seen in heart failure...
  12. ncbi request reprint Synthesis of novel bicyclo[4.1.0]heptane and bicyclo[3.1.0]hexane derivatives as melanin-concentrating hormone receptor R1 antagonists
    Jing Su
    Department of Chemical Research, Schering Plough Research Institute K15 2545, Kenilworth, NJ 07033, USA
    Bioorg Med Chem Lett 17:4845-50. 2007
    ..Biological evaluation confirmed that these new analogs retained MCH R1 activity with greatly attenuated hERG liabilities as indicated in the Rb efflux assay...