R Yan

Summary

Affiliation: Pharmacia Corporation
Country: USA

Publications

  1. ncbi BACE2 functions as an alternative alpha-secretase in cells
    R Yan
    Department of Cell and Molecular Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 276:34019-27. 2001
  2. ncbi The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate
    R Yan
    Department of Cell and Molecular Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 276:36788-96. 2001
  3. ncbi Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
    R Yan
    Cell and Molecular Biology, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Nature 402:533-7. 1999
  4. ncbi The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2
    R Yan
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Nucleic Acids Res 23:459-63. 1995
  5. ncbi Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus
    B J Lamphear
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130 3932
    J Biol Chem 268:19200-3. 1993
  6. ncbi Identification of a Stat gene that functions in Drosophila development
    R Yan
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021, USA
    Cell 84:421-30. 1996
  7. ncbi Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo
    J Yuan
    Department of Gynecology and Obstetrics, School of Medicine, JW Goethe University, 60590 Frankfurt, Germany
    Oncogene 25:1753-62. 2006
  8. ncbi Reticulon proteins: emerging players in neurodegenerative diseases
    R Yan
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, 44195, USA
    Cell Mol Life Sci 63:877-89. 2006

Collaborators

Detail Information

Publications8

  1. ncbi BACE2 functions as an alternative alpha-secretase in cells
    R Yan
    Department of Cell and Molecular Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 276:34019-27. 2001
    ..Thus, BACE2 can be distinguished from BACE1 on the basis of autoprocessing of the prosegment, APP processing specificity, and subcellular localization patterns...
  2. ncbi The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate
    R Yan
    Department of Cell and Molecular Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 276:36788-96. 2001
    ..The results suggest a molecular and cell biological mechanism for the regulation of beta-secretase activity in vivo...
  3. ncbi Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
    R Yan
    Cell and Molecular Biology, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Nature 402:533-7. 1999
    ..Thus, Asp2 is a new protein target for drugs that are designed to block the production of amyloid beta-peptide peptide and the consequent formation of amyloid plaque in Alzheimer's disease...
  4. ncbi The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2
    R Yan
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, NY 10021
    Nucleic Acids Res 23:459-63. 1995
    ..There are 24 exons in the Stat2 gene and a matching number in very similar positions in the Stat1 gene. Thus a very complicated genomic structure was presumably duplicated and has been closely maintained throughout evolution...
  5. ncbi Mapping the cleavage site in protein synthesis initiation factor eIF-4 gamma of the 2A proteases from human Coxsackievirus and rhinovirus
    B J Lamphear
    Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, Shreveport 71130 3932
    J Biol Chem 268:19200-3. 1993
    ..The cleavage site for both proteases is 479GRPALSSR decreases GPPRGGPG494 in rabbit eIF-4 gamma, corresponding to 478GRTTLSTR decreases GPPRGGPG493 in human eIF-4 gamma...
  6. ncbi Identification of a Stat gene that functions in Drosophila development
    R Yan
    Laboratory of Molecular Cell Biology, Rockefeller University, New York, New York 10021, USA
    Cell 84:421-30. 1996
    ..Mutations in either of the STAT-binding sites greatly decreased the stripe 3 expression in transgenic flies. Clearly, the JAK-STAT pathway is connected to Drosophila early development...
  7. ncbi Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo
    J Yuan
    Department of Gynecology and Obstetrics, School of Medicine, JW Goethe University, 60590 Frankfurt, Germany
    Oncogene 25:1753-62. 2006
    ....
  8. ncbi Reticulon proteins: emerging players in neurodegenerative diseases
    R Yan
    Department of Neurosciences, Lerner Research Institute, The Cleveland Clinic Foundation, Ohio, 44195, USA
    Cell Mol Life Sci 63:877-89. 2006
    ..In this review, we summarize the accumulated findings concerning the structural and functional aspects of RTNs and speculate on their linkage to the pathogenesis of neurodegenerative diseases...