R Yan

Summary

Affiliation: Pharmacia and Upjohn
Country: USA

Publications

  1. ncbi Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
    R Yan
    Cell and Molecular Biology, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Nature 402:533-7. 1999
  2. ncbi The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate
    R Yan
    Department of Cell and Molecular Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 276:36788-96. 2001
  3. ncbi BACE2 functions as an alternative alpha-secretase in cells
    R Yan
    Department of Cell and Molecular Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 276:34019-27. 2001
  4. ncbi Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo
    J Yuan
    Department of Gynecology and Obstetrics, School of Medicine, JW Goethe University, 60590 Frankfurt, Germany
    Oncogene 25:1753-62. 2006

Collaborators

Detail Information

Publications4

  1. ncbi Membrane-anchored aspartyl protease with Alzheimer's disease beta-secretase activity
    R Yan
    Cell and Molecular Biology, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Nature 402:533-7. 1999
    ..Thus, Asp2 is a new protein target for drugs that are designed to block the production of amyloid beta-peptide peptide and the consequent formation of amyloid plaque in Alzheimer's disease...
  2. ncbi The transmembrane domain of the Alzheimer's beta-secretase (BACE1) determines its late Golgi localization and access to beta -amyloid precursor protein (APP) substrate
    R Yan
    Department of Cell and Molecular Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 276:36788-96. 2001
    ..The results suggest a molecular and cell biological mechanism for the regulation of beta-secretase activity in vivo...
  3. ncbi BACE2 functions as an alternative alpha-secretase in cells
    R Yan
    Department of Cell and Molecular Biology, Pharmacia Corporation, Kalamazoo, Michigan 49007, USA
    J Biol Chem 276:34019-27. 2001
    ..Thus, BACE2 can be distinguished from BACE1 on the basis of autoprocessing of the prosegment, APP processing specificity, and subcellular localization patterns...
  4. ncbi Stable gene silencing of cyclin B1 in tumor cells increases susceptibility to taxol and leads to growth arrest in vivo
    J Yuan
    Department of Gynecology and Obstetrics, School of Medicine, JW Goethe University, 60590 Frankfurt, Germany
    Oncogene 25:1753-62. 2006
    ....