Nandini Kishore

Summary

Affiliation: Pharmacia Corporation
Country: USA

Publications

  1. ncbi A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts
    Nandini Kishore
    Department of Arthritis and Inflammation Pharmacology, Pharmacia Corp, St. Louis, Missouri 63167, USA
    J Biol Chem 278:32861-71. 2003
  2. ncbi Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer
    Q Khai Huynh
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, Mailzone T3M, 800 North Lindbergh Blvd, St Louis, MO 63167, USA
    J Biol Chem 277:12550-8. 2002
  3. ncbi IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2
    Nandini Kishore
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, St Louis, Missouri 63167, USA
    J Biol Chem 277:13840-7. 2002
  4. ncbi Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides
    Dominique Bonafoux
    Department of Medicinal Chemistry, Pfizer Inc, St Louis, MO 63017, USA
    Bioorg Med Chem Lett 15:2870-5. 2005
  5. ncbi Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease
    Srinivasan R Nagarajan
    Pfizer Global Research and Development, Pfizer Inc, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
    Bioorg Med Chem 11:4769-77. 2003

Collaborators

  • Q Khai Huynh
  • Dominique Bonafoux
  • Troii Hall
  • Srinivasan R Nagarajan
  • Gary A De Crescenzo
  • Christie L Funkes-Shippy
  • Daniel P Getman
  • Hwang Fun Lu
  • Jeffrey L Walker
  • Joseph J McDonald
  • James A Sikorski
  • Lisa Blystone
  • Kathryn A Houseman
  • Geralyn P Kocan
  • Pramod P Mehta

Detail Information

Publications5

  1. ncbi A selective IKK-2 inhibitor blocks NF-kappa B-dependent gene expression in interleukin-1 beta-stimulated synovial fibroblasts
    Nandini Kishore
    Department of Arthritis and Inflammation Pharmacology, Pharmacia Corp, St. Louis, Missouri 63167, USA
    J Biol Chem 278:32861-71. 2003
    ..Thus, the effect of SC-514 on cytokine gene expression may be a combination of inhibiting I kappa B alpha phosphorylation/degradation, affecting NF-kappa B nuclear import/export as well as the phosphorylation and transactivation of p65...
  2. ncbi Kinetic mechanisms of IkappaB-related kinases (IKK) inducible IKK and TBK-1 differ from IKK-1/IKK-2 heterodimer
    Q Khai Huynh
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, Mailzone T3M, 800 North Lindbergh Blvd, St Louis, MO 63167, USA
    J Biol Chem 277:12550-8. 2002
    ..87 microm), followed by rhIKK-i (K(IkappaBalpha) = 5.47 microm) and rhIKK-1/rhIKK-2 heterodimers (K(IkappaBalpha) = 0.12 microm). Thus this family of IkappaB kinases has very unique kinetic properties...
  3. ncbi IKK-i and TBK-1 are enzymatically distinct from the homologous enzyme IKK-2: comparative analysis of recombinant human IKK-i, TBK-1, and IKK-2
    Nandini Kishore
    Department of Arthritis and Inflammation Pharmacology, Discovery Research, Pharmacia Corporation, St Louis, Missouri 63167, USA
    J Biol Chem 277:13840-7. 2002
    ..Thus, although these IKKs are structurally similar, their enzymatic properties may provide insights into their unique functions...
  4. ncbi Inhibition of IKK-2 by 2-[(aminocarbonyl)amino]-5-acetylenyl-3-thiophenecarboxamides
    Dominique Bonafoux
    Department of Medicinal Chemistry, Pfizer Inc, St Louis, MO 63017, USA
    Bioorg Med Chem Lett 15:2870-5. 2005
    ....
  5. ncbi Discovery of novel benzothiazolesulfonamides as potent inhibitors of HIV-1 protease
    Srinivasan R Nagarajan
    Pfizer Global Research and Development, Pfizer Inc, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
    Bioorg Med Chem 11:4769-77. 2003
    ..During the course of our studies, we also developed an efficient synthesis of benzothiazole-6-sulfonic acid via a two-step procedure starting from sulfanilamide...