J C Fleishaker

Summary

Affiliation: Pharmacia Corporation
Country: USA

Publications

  1. ncbi request reprint Cardiovascular effect of almotriptan in treated hypertensive patients
    Joseph C Fleishaker
    Clinical Pharmacology Unit, Pharmacia, Kalamazoo, MI 49007, USA
    Clin Pharmacol Ther 71:169-75. 2002
  2. pmc Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans
    J C Fleishaker
    Clinical Pharmacology Unit, Pharmacia and Upjohn Company, Kalamazoo, Michigan USA
    Br J Clin Pharmacol 51:437-41. 2001
  3. ncbi request reprint Lack of effect of reboxetine on cardiac repolarization
    J C Fleishaker
    Clinical Pharmacology Unit, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Clin Pharmacol Ther 70:261-9. 2001
  4. ncbi request reprint Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression
    J C Fleishaker
    Clinical Pharmacology Unit, Pharmacia and Upjohn, Inc, Kalamazoo, Michigan 49007, USA
    Clin Pharmacokinet 39:413-27. 2000
  5. ncbi request reprint Models and methods for predicting drug transfer into human milk
    Joseph C Fleishaker
    Clinical Pharmacology, Pharmacia 7215 24 205, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    Adv Drug Deliv Rev 55:643-52. 2003
  6. ncbi request reprint Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers
    J C Fleishaker
    Clinical Pharmacology, Pharmacia and Upjohn, Inc, Kalamazoo, Mich 49007, USA
    Clin Pharmacol Ther 67:498-503. 2000
  7. ncbi request reprint Absolute bioavailability of reboxetine enantiomers and effect of gender on pharmacokinetics
    J C Fleishaker
    Clinical Pharmacokinetics Unit, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Biopharm Drug Dispos 20:53-7. 1999
  8. ncbi request reprint Lack of pharmacokinetic interaction between the antimigraine compound, almotriptan, and propranolol in healthy volunteers
    J C Fleishaker
    Clinical Pharmacology Unit, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Cephalalgia 21:61-5. 2001
  9. ncbi request reprint Evaluation of the potential pharmacokinetic interaction between almotriptan and fluoxetine in healthy volunteers
    J C Fleishaker
    Clinical Pharmacology Unit, 7215-24-205, Pharmacia and Upjohn Company, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    J Clin Pharmacol 41:217-23. 2001
  10. ncbi request reprint Induction of tirilazad clearance by phenytoin
    J C Fleishaker
    Clinical Pharmacokinetics Unit, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Biopharm Drug Dispos 19:91-6. 1998

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Cardiovascular effect of almotriptan in treated hypertensive patients
    Joseph C Fleishaker
    Clinical Pharmacology Unit, Pharmacia, Kalamazoo, MI 49007, USA
    Clin Pharmacol Ther 71:169-75. 2002
    ..Our objective was to investigate the cardiovascular effects of almotriptan, a 5-hydroxytryptamine 1B/1D agonist, in treated patients with hypertension...
  2. pmc Effect of MAO-A inhibition on the pharmacokinetics of almotriptan, an antimigraine agent in humans
    J C Fleishaker
    Clinical Pharmacology Unit, Pharmacia and Upjohn Company, Kalamazoo, Michigan USA
    Br J Clin Pharmacol 51:437-41. 2001
    ..To assess the effect of a reversible MAO-A inhibitor, moclobemide, on the single-dose pharmacokinetics of almotriptan and assess the clinical consequences of any interaction...
  3. ncbi request reprint Lack of effect of reboxetine on cardiac repolarization
    J C Fleishaker
    Clinical Pharmacology Unit, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Clin Pharmacol Ther 70:261-9. 2001
    ..The effect of reboxetine on electrocardiographic parameters, particularly the QTc interval, was assessed in 20 healthy subjects (15 male, 5 female)...
  4. ncbi request reprint Clinical pharmacokinetics of reboxetine, a selective norepinephrine reuptake inhibitor for the treatment of patients with depression
    J C Fleishaker
    Clinical Pharmacology Unit, Pharmacia and Upjohn, Inc, Kalamazoo, Michigan 49007, USA
    Clin Pharmacokinet 39:413-27. 2000
    ..Thus, reboxetine is not likely to affect the clearance of other drugs metabolised by CYP isozymes...
  5. ncbi request reprint Models and methods for predicting drug transfer into human milk
    Joseph C Fleishaker
    Clinical Pharmacology, Pharmacia 7215 24 205, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    Adv Drug Deliv Rev 55:643-52. 2003
    ..This article reviews these approaches in terms of their utility, advantages and disadvantages. Some combination of these methods is necessary for reasonably accurate prediction of M/P in humans...
  6. ncbi request reprint Pharmacokinetic interaction between verapamil and almotriptan in healthy volunteers
    J C Fleishaker
    Clinical Pharmacology, Pharmacia and Upjohn, Inc, Kalamazoo, Mich 49007, USA
    Clin Pharmacol Ther 67:498-503. 2000
    ..To assess the interaction between almotriptan, a 5-HT1B/1D-receptor agonist used to treat migraine, and verapamil, an agent for migraine prophylaxis...
  7. ncbi request reprint Absolute bioavailability of reboxetine enantiomers and effect of gender on pharmacokinetics
    J C Fleishaker
    Clinical Pharmacokinetics Unit, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Biopharm Drug Dispos 20:53-7. 1999
    ..There are no clinically significant effects of gender on the pharmacokinetics of reboxetine enantiomers...
  8. ncbi request reprint Lack of pharmacokinetic interaction between the antimigraine compound, almotriptan, and propranolol in healthy volunteers
    J C Fleishaker
    Clinical Pharmacology Unit, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Cephalalgia 21:61-5. 2001
    ..The results show that propranolol has no effect on the pharmacokinetics of almotriptan. Concomitant administration of the two drugs is well tolerated...
  9. ncbi request reprint Evaluation of the potential pharmacokinetic interaction between almotriptan and fluoxetine in healthy volunteers
    J C Fleishaker
    Clinical Pharmacology Unit, 7215-24-205, Pharmacia and Upjohn Company, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    J Clin Pharmacol 41:217-23. 2001
    ..The results show that fluoxetine has only a modest effect on almotriptan Cmax. Concomitant administration of the two drugs is well tolerated, and no adjustment of the almotriptan dose is warranted...
  10. ncbi request reprint Induction of tirilazad clearance by phenytoin
    J C Fleishaker
    Clinical Pharmacokinetics Unit, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Biopharm Drug Dispos 19:91-6. 1998
    ..The results show that phenytoin induces metabolism of tirilazad and U-89678 in healthy subjects and that, under these conditions, tirilazad clearance approaches liver blood flow...
  11. ncbi request reprint A comparison of the pharmacokinetics and tolerability of the anti-migraine compound almotriptan in healthy adolescents and adults
    J R Baldwin
    Department of Clinical Pharmacology, Pharmacia, Kalamazoo, MI 49001, USA
    Cephalalgia 24:288-92. 2004
    ..Based on these pharmacokinetic and tolerability findings, no dose adjustment for almotriptan would be required when treating patients as young as 12 years old...
  12. ncbi request reprint Pharmacokinetics of reboxetine in healthy volunteers with different ethnic descents
    P E Hendershot
    Clinical Pharmacology II, Pharmacia and Upjohn, Inc, Kalamazoo, MI 49007, USA
    Psychopharmacology (Berl) 155:148-53. 2001
    ..CONCLUSIONS: The AUCu difference between Asian and black and Caucasian subjects was modest. Tolerability differences among groups were not observed. No dosage adjustment is necessary for Asians or blacks...
  13. ncbi request reprint Population pharmacokinetics of tirilazad: effects of weight, gender, concomitant phenytoin, and subarachnoid hemorrhage
    J C Fleishaker
    Clinical Pharmacokinetics Unit, Pharmacia and Upjohn, Kalamazoo, Michigan 49007, USA
    Pharm Res 16:575-83. 1999
    ..Data collected during Phase I and II in the development of tirilazad were pooled and analyzed using nonlinear mixed effects models to assess covariates which might affect tirilazad pharmacokinetics...
  14. ncbi request reprint Interaction between ketoconazole and almotriptan in healthy volunteers
    Joseph C Fleishaker
    Clinical Pharmacology Unit, 7215 24 205, Pharmacia and Upjohn, Inc, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    J Clin Pharmacol 43:423-7. 2003
    ..These effects were statistically significant. The effects of ketoconazole on almotriptan clearance were consistent with inhibition of the CYP3A4-mediated metabolism and a slight effect on the active tubular secretion of almotriptan...
  15. ncbi request reprint Valdecoxib, a COX-2-specific inhibitor, does not affect cardiac repolarization
    Nenad Sarapa
    Department of Clinical Pharmacology, Pharmacia Corporation, 5200 Old Orchard Road, Skokie, IL 60077, USA
    J Clin Pharmacol 43:974-82. 2003
    ....
  16. ncbi request reprint Clinical pharmacokinetics of almotriptan, a serotonin 5-HT(1B/1D) receptor agonist for the treatment of migraine
    Janet D McEnroe
    Clinical Pharmacology Unit, Pharmacia, Inc, Kalamazoo, Michigan, USA
    Clin Pharmacokinet 44:237-46. 2005
    ..Although ketoconazole has a greater effect on almotriptan clearance than verapamil, no dosage adjustment is required when almotriptan is given with these drugs...
  17. ncbi request reprint Kinetics and dynamics of intravenous adinazolam, N-desmethyl adinazolam, and alprazolam in healthy volunteers
    Karthik Venkatakrishnan
    Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, 136 Harrison Avenue, Boston, MA 02111, USA
    J Clin Pharmacol 45:529-37. 2005
    ..Collectively, these results indicate that the benzodiazepine-like effects occurring after adinazolam administration are mediated by mainly NDMAD...
  18. ncbi request reprint Electrocardiographic identification of drug-induced QT prolongation: assessment by different recording and measurement methods
    Nenad Sarapa
    Clinical Pharmacology, Pharmacia Corp, Kalamazoo, Michigan, USA
    Ann Noninvasive Electrocardiol 9:48-57. 2004
    ..Manual methods (digitizing pad and digital on-screen calipers) were compared for precision of QT and RR interval measurement...
  19. ncbi request reprint Anticipatory anxiety in moderately to highly-anxious oral surgery patients as a screening model for anxiolytics: evaluation of alprazolam
    Daniel L Wolf
    Clinical Pharmacology, Pharmacia Corporation, Kalamazoo, Michigan 49001, USA
    J Clin Psychopharmacol 23:51-7. 2003
    ..Overall, the oral surgery anticipation anxiety model was found to be a sensitive test for benzodiazepine anxiolytic activity and may represent a potential screening model for evaluation of investigational agents...
  20. doi request reprint Performance characteristics for some typical QT study designs under the ICH E-14 guidance
    Matthew M Hutmacher
    Pfizer Inc, Ann Arbor, Michigan, USA
    J Clin Pharmacol 48:215-24. 2008
    ..Ultimately, these results reveal significant limitations of the IUT with respect to excluding an effect and study interpretation for certain trial designs...