D E Epps

Summary

Affiliation: Pharmacia and Upjohn
Country: USA

Publications

  1. ncbi request reprint Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide
    Nancy C Stratman
    Neurobiology, Pfizer Inc, Kalamazoo, MI 49001, USA
    Chem Phys Lipids 137:52-61. 2005
  2. ncbi request reprint A competitive fluorescence assay to measure the reactivity of compounds
    D E Epps
    Pharmacia Corporation, Kalamazoo, Michigan 49002, USA
    Anal Biochem 295:101-6. 2001
  3. ncbi request reprint The essential role of a free sulfhydryl group in blocking the cholesteryl site of cholesteryl ester transfer protein (CETP)
    Dennis E Epps
    Discovery Technologies, 7295 25 234 Pharmacia and Upjohn Company, 301 Henrietta, Kalamazoo, MI 49001, USA
    Chem Phys Lipids 114:113-22. 2002
  4. ncbi request reprint The ligand affinity of proteins measured by isothermal denaturation kinetics
    D E Epps
    Pharmacia Corporation, 7000 Portage Road, Kalamazoo, Michigan 49001, USA
    Anal Biochem 292:40-50. 2001
  5. ncbi request reprint Determination of ligand-MurB interactions by isothermal denaturation: application as a secondary assay to complement high throughput screening
    Ronald W Sarver
    Structural and Medicinal Chemistry, Pharmacia Corporation, Kalamazoo, MI 49001, USA
    J Biomol Screen 7:21-8. 2002
  6. ncbi request reprint Physical methods to determine the binding mode of putative ligands for hepatitis C virus NS3 helicase
    Ronald W Sarver
    Structural, Analytical and Medicinal Chemistry, 301 Henrietta Street, Kalamazoo, MI 49001, USA
    Anal Biochem 309:186-95. 2002
  7. ncbi request reprint Spontaneous aggregation and cytotoxicity of the beta-amyloid Abeta1-40: a kinetic model
    Bruce M Taylor
    Pharmacia Inc, 7295 25 234, 301 Henrietta St Kalamazoo, MI 4900, USA
    J Protein Chem 22:31-40. 2003
  8. ncbi request reprint A slowly formed transient conformer of Abeta(1-40) is toxic to inward channels of dissociated hippocampal and cortical neurons of rats
    Xiao Dong Sun
    Discovery Technologies Toxicology, Pharmacia Inc, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    Neurobiol Dis 14:567-78. 2003

Collaborators

  • J M Rogers
  • R W Sarver
  • Bruce M Taylor
  • Nancy C Stratman
  • Xiao Dong Sun
  • Donald B Carter
  • Christine K Castle
  • George W Melchior
  • Karl Kappenman
  • Barry S Lutzke
  • Zun Li Mo
  • Allen E Buhl
  • Antonio Molinari
  • Roger A Poorman
  • Thomas Kawabe
  • Gregory Fici

Detail Information

Publications8

  1. ncbi request reprint Isoform-specific interactions of human apolipoprotein E to an intermediate conformation of human Alzheimer amyloid-beta peptide
    Nancy C Stratman
    Neurobiology, Pfizer Inc, Kalamazoo, MI 49001, USA
    Chem Phys Lipids 137:52-61. 2005
    ..The differential risk of AD related to apoE genotype may be the result of an enhanced capacity of apoE4 binding to an intermediate aggregated form of Abeta...
  2. ncbi request reprint A competitive fluorescence assay to measure the reactivity of compounds
    D E Epps
    Pharmacia Corporation, Kalamazoo, Michigan 49002, USA
    Anal Biochem 295:101-6. 2001
    ..The method is easily adaptable to a high-throughput screening format...
  3. ncbi request reprint The essential role of a free sulfhydryl group in blocking the cholesteryl site of cholesteryl ester transfer protein (CETP)
    Dennis E Epps
    Discovery Technologies, 7295 25 234 Pharmacia and Upjohn Company, 301 Henrietta, Kalamazoo, MI 49001, USA
    Chem Phys Lipids 114:113-22. 2002
    ..Finally, although not conclusive, results of the protein chemistry experiments with the modified CETP suggest that the cysteine residue at position 333 is unpaired...
  4. ncbi request reprint The ligand affinity of proteins measured by isothermal denaturation kinetics
    D E Epps
    Pharmacia Corporation, 7000 Portage Road, Kalamazoo, Michigan 49001, USA
    Anal Biochem 292:40-50. 2001
    ....
  5. ncbi request reprint Determination of ligand-MurB interactions by isothermal denaturation: application as a secondary assay to complement high throughput screening
    Ronald W Sarver
    Structural and Medicinal Chemistry, Pharmacia Corporation, Kalamazoo, MI 49001, USA
    J Biomol Screen 7:21-8. 2002
    ..We showed that coupling of the various detection methods with isothermal denaturation yields a powerful regimen to provide analytical data for assessing inhibitor specificity for a protein target...
  6. ncbi request reprint Physical methods to determine the binding mode of putative ligands for hepatitis C virus NS3 helicase
    Ronald W Sarver
    Structural, Analytical and Medicinal Chemistry, 301 Henrietta Street, Kalamazoo, MI 49001, USA
    Anal Biochem 309:186-95. 2002
    ..A combination of physical methods was required to discern the mode of action of compounds identified by HTS and remove undesirable lead templates from further consideration...
  7. ncbi request reprint Spontaneous aggregation and cytotoxicity of the beta-amyloid Abeta1-40: a kinetic model
    Bruce M Taylor
    Pharmacia Inc, 7295 25 234, 301 Henrietta St Kalamazoo, MI 4900, USA
    J Protein Chem 22:31-40. 2003
    ..These conclusions should provide a structural basis for understanding the toxicity of Abeta1-40 in vitro and possibly in vivo...
  8. ncbi request reprint A slowly formed transient conformer of Abeta(1-40) is toxic to inward channels of dissociated hippocampal and cortical neurons of rats
    Xiao Dong Sun
    Discovery Technologies Toxicology, Pharmacia Inc, 301 Henrietta Street, Kalamazoo, MI 49007, USA
    Neurobiol Dis 14:567-78. 2003
    ..We conclude that, for both the native neurons in the present study as well as SH-EP1 cells, the activated monomeric conformer of the peptide is the toxic species...