Toshinori Yamamoto

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches--effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine
    Toshinori Yamamoto
    Drug Safety Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Toxicol Sci 32:205-15. 2007
  2. ncbi In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system
    Rie Kikkawa
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Toxicol Sci 31:23-34. 2006
  3. ncbi Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants
    Toshinori Yamamoto
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Toxicol Sci 31:49-60. 2006
  4. ncbi Integrated NMR-based metabonomic investigation of early metabolic effects of ethylene glycol monomethyl ether (EGME) on male reproductive organs in rats
    Toshinori Yamamoto
    Drug Safety Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, Aichi, Japan
    J Toxicol Sci 32:515-28. 2007
  5. ncbi Identification of oxidative stress-related proteins for predictive screening of hepatotoxicity using a proteomic approach
    Toshinori Yamamoto
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Aichi
    J Toxicol Sci 30:213-27. 2005
  6. ncbi Effects of male reproductive toxicants on gene expression in rat testes
    Tamio Fukushima
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, Aichi
    J Toxicol Sci 30:195-206. 2005
  7. ncbi Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants
    Toshinori Yamamoto
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, Taketoyo, Aichi, Japan
    J Toxicol Sci 30:111-26. 2005
  8. ncbi Investigation of a hepatotoxicity screening system in primary cell cultures --"what biomarkers would need to be addressed to estimate toxicity in conventional and new approaches?"
    Rie Kikkawa
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, Aichi 470 2393, Japan
    J Toxicol Sci 30:61-72. 2005
  9. ncbi Rat organic solute carrier protein 1 (rOscp1) mediated the transport of organic solutes in Xenopus laevis oocytes: isolation and pharmacological characterization of rOscp1
    Hisanori Izuno
    Department of Surgery, School of Medicine, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama shi, Kanagawa 227 8501, Japan
    Life Sci 81:1183-92. 2007
  10. ncbi Human organic anion transporters mediate the transport of tetracycline
    Ellappan Babu
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka shi, Tokyo, Japan
    Jpn J Pharmacol 88:69-76. 2002

Collaborators

  • Rie Kikkawa
  • Tamio Fukushima
  • Yasushi Sato
  • Kaori Tomizawa
  • Chisato Mori
  • T Niwa
  • Takeshi Aoki
  • Yasuna Kobayashi
  • Masayuki Ohbayashi
  • Noriko Kohyama
  • Naomi Ohshiro
  • Takashi Sekine
  • Hitoshi Endou
  • Hisanori Izuno
  • Tomotake Koizumi
  • Suhk mann Kim
  • Seok Ho Cha
  • Atsushi Enomoto
  • Shinichi Narikawa
  • Ellappan Babu
  • Michio Takeda
  • Hirohisa Kato
  • Zhenghao Jin
  • Tomofumi Hayashi
  • Takashi Niiya
  • Daisuke Nihei
  • Keitaro Mitamura
  • Ayumi Tsuchiya
  • Yoshihiko Izumida
  • Masako Suzuki
  • Mitsuo Kusano
  • Daisuke Yasuda
  • Yoshinori Shimizu
  • Noriyuki Murai
  • Yutaka Sanada
  • Yuta Enami
  • Nobukazu Nishino
  • Jang Su Park
  • Hideo Akutsu
  • Yasuto Todokoro
  • Toshimichi Fujiwara
  • Yuki Takayama
  • Akiko Shibusawa
  • Hironori Saito
  • Ryoko Sakai
  • Dhanapal Sakthisekaran
  • Tadanori Sasaki
  • Noriko Hirokawa
  • Minoru Shimoda
  • Shogo Tokuyama
  • Yukari Kobayashi

Detail Information

Publications18

  1. ncbi Evaluation of human hepatocyte chimeric mice as a model for toxicological investigation using panomic approaches--effect of acetaminophen on the expression profiles of proteins and endogenous metabolites in liver, plasma and urine
    Toshinori Yamamoto
    Drug Safety Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Toxicol Sci 32:205-15. 2007
    ..Further investigations are needed to detect idiosyncratic hepatotoxicity in humans using chimeric mice...
  2. ncbi In vivo hepatotoxicity study of rats in comparison with in vitro hepatotoxicity screening system
    Rie Kikkawa
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Toxicol Sci 31:23-34. 2006
    ....
  3. ncbi Investigation of proteomic biomarkers in in vivo hepatotoxicity study of rat liver: toxicity differentiation in hepatotoxicants
    Toshinori Yamamoto
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, 5 2 Taketoyo, Aichi 470 2393, Japan
    J Toxicol Sci 31:49-60. 2006
    ..These results suggested that assessing the effects of hepatotoxicants on protein expression is worth trying to screen candidate compounds at the developmental stage of drugs...
  4. ncbi Integrated NMR-based metabonomic investigation of early metabolic effects of ethylene glycol monomethyl ether (EGME) on male reproductive organs in rats
    Toshinori Yamamoto
    Drug Safety Research and Development, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, Aichi, Japan
    J Toxicol Sci 32:515-28. 2007
    ..Furthermore, Hr-MAS (1)H-NMR proved useful to investigate the molecular snapshot of biological tissues and the mechanism of toxicity...
  5. ncbi Identification of oxidative stress-related proteins for predictive screening of hepatotoxicity using a proteomic approach
    Toshinori Yamamoto
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Aichi
    J Toxicol Sci 30:213-27. 2005
    ....
  6. ncbi Effects of male reproductive toxicants on gene expression in rat testes
    Tamio Fukushima
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Japan Inc, Aichi
    J Toxicol Sci 30:195-206. 2005
    ..These data suggest that cDNA microarray is a useful technique for evaluation of primary testicular toxicity. Furthermore, we propose the above 3 spermatogenesis-related genes as potential biomarkers of testicular toxicity...
  7. ncbi Protein expression analysis of rat testes induced testicular toxicity with several reproductive toxicants
    Toshinori Yamamoto
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, Taketoyo, Aichi, Japan
    J Toxicol Sci 30:111-26. 2005
    ..Therefore, the proteins identified in this study could potentially serve as biomarkers to evaluate male reproductive toxicity at an early stage of drug discovery and development...
  8. ncbi Investigation of a hepatotoxicity screening system in primary cell cultures --"what biomarkers would need to be addressed to estimate toxicity in conventional and new approaches?"
    Rie Kikkawa
    Worldwide Safety Sciences, Pfizer Global Research and Development, Nagoya Laboratories, Pfizer Inc, Aichi 470 2393, Japan
    J Toxicol Sci 30:61-72. 2005
    ..Further comprehensive analysis of defined proteins would be necessary to estimate the more sensitive toxicology biomarker...
  9. ncbi Rat organic solute carrier protein 1 (rOscp1) mediated the transport of organic solutes in Xenopus laevis oocytes: isolation and pharmacological characterization of rOscp1
    Hisanori Izuno
    Department of Surgery, School of Medicine, Showa University Fujigaoka Hospital, 1 30 Fujigaoka, Aoba ku, Yokohama shi, Kanagawa 227 8501, Japan
    Life Sci 81:1183-92. 2007
    ..Thus, the present results indicate that a newly isolated cDNA clone, rOscp1, is a polyspecific organic solute carrier protein with some differences in substrate specificity compared with human and mouse OSCP1...
  10. ncbi Human organic anion transporters mediate the transport of tetracycline
    Ellappan Babu
    Department of Pharmacology and Toxicology, Kyorin University School of Medicine, Mitaka shi, Tokyo, Japan
    Jpn J Pharmacol 88:69-76. 2002
    ..These pharmacological characteristics of hOATs may be significantly related to events associated with the development of tetracycline-induced nephrotoxicity in the human kidney...
  11. ncbi Isolation and characterization of polyspecific mouse organic solute carrier protein 1 (mOscp1)
    Yasuna Kobayashi
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, Tokyo, Japan
    Drug Metab Dispos 35:1239-45. 2007
    ..Our results indicate that isolated mOscp1 is a polyspecific organic solute carrier protein and may be a key molecule for the testicular handling of organic solutes...
  12. ncbi Long-term maintenance of the drug transport activity in cryopreservation of microencapsulated rat hepatocytes
    Tomotake Koizumi
    Second Department of Surgery, School of Medicine, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Cell Transplant 16:67-73. 2007
    ..Our results thus demonstrate for the first time that cryopreservation of primary rat hepatocytes by the encapsulation technique allows long-term retention of drug metabolism and drug transport activities...
  13. ncbi Interaction of human organic anion transporters 2 and 4 with organic anion transport inhibitors
    Atsushi Enomoto
    Department of Clinical Preventive Medicine, Nagoya University School of Medicine, Nagoya, Japan
    J Pharmacol Exp Ther 301:797-802. 2002
    ..Comparing the K(i) values with the therapeutically relevant concentrations of unbound inhibitors in the plasma, probenecid alone was predicted to inhibit hOAT4-mediated organic anion transport in vivo...
  14. ncbi [Current educational status of clinical toxicology in pharmaceutical sciences]
    Takemi Yamamoto
    Chudoku Kenkyu 15:355-9. 2002
  15. pmc Phospholipid-dependent regulation of cytochrome c3-mediated electron transport across membranes
    Suhk mann Kim
    Faculty of Engineering, Yokohama National University, Yokohama 240 8501, Japan
    Biophys J 90:506-13. 2006
    ..Also, cyt c3 penetrates into membranes, which would induce distortion of the lipid bilayer. The molecular mechanisms underlying the single- and two-molecule processes are discussed in terms of membrane structure...
  16. ncbi Possible involvement of organic anion transporter 2 on the interaction of theophylline with erythromycin in the human liver
    Yasuna Kobayashi
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, Japan
    Drug Metab Dispos 33:619-22. 2005
    ..Our present findings suggest that hOat2 may, at least in part, be involved in the theophylline-erythromycin interaction in the human liver...
  17. ncbi Isolation and functional characterization of a novel organic solute carrier protein, hOSCP1
    Yasuna Kobayashi
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, Shinagawa ku, Tokyo, Japan
    J Biol Chem 280:32332-9. 2005
    ..Our results suggest that hOSCP1 is a novel polyspecific organic solute carrier protein responsible for drug clearance from the human placenta...
  18. ncbi Differential gene expression of organic anion transporters in male and female rats
    Yasuna Kobayashi
    Department of Clinical Pharmacy, School of Pharmaceutical Sciences, Showa University, 1 5 8 Hatanodai, Shinagawa ku, Tokyo 142 8555, Japan
    Biochem Biophys Res Commun 290:482-7. 2002
    ..Our results provide information on the differential gene expression of OAT isoforms with sex hormone dependency...