Andrew J Thorpe

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target
    Andrew J Thorpe
    Pfizer Inc, US Medical Affairs, New York, NY 10017, USA
    Curr Opin Investig Drugs 11:761-70. 2010
  2. pmc Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping
    Meiping Chang
    Indications Discovery Research Unit, Pfizer Global Research and Development, Chesterfield, MO 63017, USA
    Mol Pain 6:56. 2010
  3. doi request reprint Possible sites of therapeutic action in restless legs syndrome: focus on dopamine and α2δ ligands
    Andrew J Thorpe
    Pfizer Inc, 235 East 42nd Street, New York, N Y 10017, USA
    Eur Neurol 66:18-29. 2011
  4. ncbi request reprint Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein
    Jacob B Schwarz
    Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA
    J Med Chem 48:3026-35. 2005
  5. ncbi request reprint Carboxylate bioisosteres of pregabalin
    Jacob B Schwarz
    Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, 48105, USA
    Bioorg Med Chem Lett 16:3559-63. 2006

Collaborators

Detail Information

Publications5

  1. ncbi request reprint The alpha2-delta protein: an auxiliary subunit of voltage-dependent calcium channels as a recognized drug target
    Andrew J Thorpe
    Pfizer Inc, US Medical Affairs, New York, NY 10017, USA
    Curr Opin Investig Drugs 11:761-70. 2010
    ..Finally, new insights into the mechanism of drugs that bind to this protein are discussed...
  2. pmc Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping
    Meiping Chang
    Indications Discovery Research Unit, Pfizer Global Research and Development, Chesterfield, MO 63017, USA
    Mol Pain 6:56. 2010
    ..The aim of this study was to identify genes altered in this model of osteoarthritic pain and use this information to infer analgesic potential of compounds based on their own gene expression profiles using the Connectivity Map approach...
  3. doi request reprint Possible sites of therapeutic action in restless legs syndrome: focus on dopamine and α2δ ligands
    Andrew J Thorpe
    Pfizer Inc, 235 East 42nd Street, New York, N Y 10017, USA
    Eur Neurol 66:18-29. 2011
    ..The known and possible therapeutic benefits of these agents and their relationship to dopaminergic dysfunction in RLS are discussed in this review...
  4. ncbi request reprint Novel cyclopropyl beta-amino acid analogues of pregabalin and gabapentin that target the alpha2-delta protein
    Jacob B Schwarz
    Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA
    J Med Chem 48:3026-35. 2005
    ..However, pregabalin 1 was active in the DBA/2 model after oral (and icv) dosing, supporting a hypothesis that active transport is a prerequisite for such zwitterionic species to cross the blood-brain barrier...
  5. ncbi request reprint Carboxylate bioisosteres of pregabalin
    Jacob B Schwarz
    Pfizer Global Research and Development, Michigan Laboratories, 2800 Plymouth Road, Ann Arbor, 48105, USA
    Bioorg Med Chem Lett 16:3559-63. 2006
    ..Two select compounds with potent affinity for alpha(2)-delta, 8a and 16a, were subsequently tested in vivo in an audiogenic seizure model and found to elicit protective effects...