Stephanie T Shi

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. pmc Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase
    Lu Gao
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 1054, USA
    J Virol 77:4149-59. 2003
  2. pmc In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
    Stephanie T Shi
    Department of Virology, Pfizer Global Research and Development, La Jolla Laboratories, 10777 Science Center Drive, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 52:675-83. 2008
  3. pmc Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
    Stephanie T Shi
    Department of Cancer Biology, Pfizer Global Research and Development, La Jolla Laboratories, 10724 Science Center Drive, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 53:2544-52. 2009
  4. doi request reprint Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
    Hui Li
    Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California 92121, USA
    J Med Chem 52:1255-8. 2009
  5. doi request reprint Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges
    Hui Li
    Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, CA 9212, USA
    Future Med Chem 2:121-41. 2010
  6. pmc Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors
    Koleen J Herlihy
    Pfizer Global Research and Development, La Jolla Laboratories, 10724 Science Center Drive, San Diego, California 92121, USA
    Antimicrob Agents Chemother 52:3523-31. 2008
  7. ncbi request reprint Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins
    Stephanie T Shi
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Virology 292:198-210. 2002
  8. pmc Rolling circle replication of hepatitis delta virus RNA is carried out by two different cellular RNA polymerases
    Thomas B Macnaughton
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 1054, USA
    J Virol 76:3920-7. 2002
  9. pmc Hepatitis C virus RNA replication occurs on a detergent-resistant membrane that cofractionates with caveolin-2
    Stephanie T Shi
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Virol 77:4160-8. 2003

Collaborators

Detail Information

Publications9

  1. pmc Interaction with a ubiquitin-like protein enhances the ubiquitination and degradation of hepatitis C virus RNA-dependent RNA polymerase
    Lu Gao
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 1054, USA
    J Virol 77:4149-59. 2003
    ..Thus, hPLIC1 may be a regulator of HCV RNA replication through interaction with NS5B...
  2. pmc In vitro resistance study of AG-021541, a novel nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
    Stephanie T Shi
    Department of Virology, Pfizer Global Research and Development, La Jolla Laboratories, 10777 Science Center Drive, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 52:675-83. 2008
    ..The clinical relevance of in vitro resistance to HCV polymerase inhibitors remains to be investigated...
  3. pmc Preclinical characterization of PF-00868554, a potent nonnucleoside inhibitor of the hepatitis C virus RNA-dependent RNA polymerase
    Stephanie T Shi
    Department of Cancer Biology, Pfizer Global Research and Development, La Jolla Laboratories, 10724 Science Center Drive, San Diego, CA 92121, USA
    Antimicrob Agents Chemother 53:2544-52. 2009
    ..Our results demonstrate that PF-00868554 has potent and broad-spectrum antiviral activity against genotype 1 HCV strains, supporting its use as an oral antiviral agent in HCV-infected patients...
  4. doi request reprint Discovery of (R)-6-cyclopentyl-6-(2-(2,6-diethylpyridin-4-yl)ethyl)-3-((5,7-dimethyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl)methyl)-4-hydroxy-5,6-dihydropyran-2-one (PF-00868554) as a potent and orally available hepatitis C virus polymerase inhibitor
    Hui Li
    Pfizer Global Research and Development, La Jolla Laboratories, San Diego, California 92121, USA
    J Med Chem 52:1255-8. 2009
    ..Compound 24 is a potent and selective HCV polymerase inhibitor with a favorable pharmacokinetic profile and has recently entered a phase II clinical evaluation in patients with genotype 1 HCV...
  5. doi request reprint Non-nucleoside inhibitors of hepatitis C virus polymerase: current progress and future challenges
    Hui Li
    Pfizer Global Research and Development, La Jolla Laboratories, 10770 Science Center Drive, San Diego, CA 9212, USA
    Future Med Chem 2:121-41. 2010
    ..In this review, we summarize the recent progress in the discovery of non-nucleoside HCV polymerase inhibitors with a focus on novel chemical matters, their clinical efficacy, safety and potential for combination therapy...
  6. pmc Development of intergenotypic chimeric replicons to determine the broad-spectrum antiviral activities of hepatitis C virus polymerase inhibitors
    Koleen J Herlihy
    Pfizer Global Research and Development, La Jolla Laboratories, 10724 Science Center Drive, San Diego, California 92121, USA
    Antimicrob Agents Chemother 52:3523-31. 2008
    ..Our study demonstrates the utility of chimeric replicons for broad-spectrum activity determination of HCV inhibitors...
  7. ncbi request reprint Hepatitis C virus NS5A colocalizes with the core protein on lipid droplets and interacts with apolipoproteins
    Stephanie T Shi
    Department of Molecular Microbiology and Immunology, University of Southern California, Keck School of Medicine, Los Angeles, California 90033, USA
    Virology 292:198-210. 2002
    ....
  8. pmc Rolling circle replication of hepatitis delta virus RNA is carried out by two different cellular RNA polymerases
    Thomas B Macnaughton
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033 1054, USA
    J Virol 76:3920-7. 2002
    ....
  9. pmc Hepatitis C virus RNA replication occurs on a detergent-resistant membrane that cofractionates with caveolin-2
    Stephanie T Shi
    Department of Molecular Microbiology and Immunology, Keck School of Medicine, University of Southern California, Los Angeles, California 90033, USA
    J Virol 77:4160-8. 2003
    ..We suggest that HCV RNA synthesis occurs on a lipid raft membrane structure...