Jasminder Sahi

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs
    Jasminder Sahi
    Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Drug Metab Dispos 30:135-40. 2002
  2. ncbi request reprint Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo
    Jasminder Sahi
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA
    Drug Metab Dispos 32:1370-6. 2004
  3. ncbi request reprint Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor
    Jasminder Sahi
    Department of Pharmacokinetics, Pfizer Global Research and Development, Ann Arbor MI 48105, USA
    J Pharmacol Exp Ther 306:1027-34. 2003
  4. ncbi request reprint Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition
    Jasminder Sahi
    Department of Pharmacokinetics Pharmacodynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Drug Metab Dispos 31:439-46. 2003
  5. ncbi request reprint Metabolism and transporter-mediated drug-drug interactions of the endothelin-A receptor antagonist CI-1034
    Jasminder Sahi
    Department of Pharmacokinetics Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Chem Biol Interact 159:156-68. 2006
  6. doi request reprint Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes
    Jasminder Sahi
    Department of Pharmacokinetics Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    J Biochem Mol Toxicol 23:43-58. 2009
  7. ncbi request reprint Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats
    Vsevolod E Kostrubsky
    Department of Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Sci 76:220-8. 2003
  8. ncbi request reprint Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
    Jessica B Mills
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    J Pharmacol Exp Ther 309:303-9. 2004
  9. ncbi request reprint Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes
    Yuan Hua Wen
    Department of Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Drug Metab Dispos 30:977-84. 2002
  10. ncbi request reprint Hepatobiliary disposition in primary cultures of dog and monkey hepatocytes
    Kelly A Rose
    Department of Pharmacokinetics, Pharmacodynamics, and Metabolism and Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Mol Pharm 3:266-74. 2006

Collaborators

Detail Information

Publications13

  1. ncbi request reprint The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs
    Jasminder Sahi
    Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Drug Metab Dispos 30:135-40. 2002
    ..In jejunal microsomes, CYP3A12 activity doubled with bergamottin treatment. CYP2B11, CYP1A1/2 activity and tolbutamide hydroxylation was not detected. In conclusion, bergamottin is both an inhibitor and an inducer of P450 enzymes...
  2. ncbi request reprint Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo
    Jasminder Sahi
    Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105, USA
    Drug Metab Dispos 32:1370-6. 2004
    ..2% reduction in trough concentrations of S-warfarin and decreased prothrombin times by 12, 15, 19, and 21% on days 6 through 9, respectively. These results demonstrate that avasimibe's inductive spectrum resembles that of rifampin...
  3. ncbi request reprint Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor
    Jasminder Sahi
    Department of Pharmacokinetics, Pfizer Global Research and Development, Ann Arbor MI 48105, USA
    J Pharmacol Exp Ther 306:1027-34. 2003
    ..Our results indicate that avasimibe causes clinically significant drug-drug interactions through direct activation of hPXR and the subsequent induction of its target genes CYP3A4 and multiple drug resistance protein 1...
  4. ncbi request reprint Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition
    Jasminder Sahi
    Department of Pharmacokinetics Pharmacodynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Drug Metab Dispos 31:439-46. 2003
    ..While only the induction of CYP3A4 by troglitazone has been demonstrated in vivo, these results suggest that other thiazolidinediones may have the potential to cause clinically significant drug interactions at sufficiently high doses...
  5. ncbi request reprint Metabolism and transporter-mediated drug-drug interactions of the endothelin-A receptor antagonist CI-1034
    Jasminder Sahi
    Department of Pharmacokinetics Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Chem Biol Interact 159:156-68. 2006
    ..We recommend that in vitro drug-drug interaction panels include inhibition and induction studies with transporters and drug metabolizing enzymes, to more completely assess potential in vivo interactions or toxicity...
  6. doi request reprint Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes
    Jasminder Sahi
    Department of Pharmacokinetics Pharmacodynamics and Metabolism, Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    J Biochem Mol Toxicol 23:43-58. 2009
    ....
  7. ncbi request reprint Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats
    Vsevolod E Kostrubsky
    Department of Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Toxicol Sci 76:220-8. 2003
    ..These results provide methods to evaluate inhibitory effects of potentially cholestatic compounds on bile-acid transport, and to rank compounds according to their hepatotoxic potential...
  8. ncbi request reprint Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line
    Jessica B Mills
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    J Pharmacol Exp Ther 309:303-9. 2004
    ....
  9. ncbi request reprint Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes
    Yuan Hua Wen
    Department of Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Drug Metab Dispos 30:977-84. 2002
    ..These results suggest that bergamottin causes both inhibition of CYP3A and CYP1A1/2 enzymatic activities and induction of correspondent proteins and mRNAs...
  10. ncbi request reprint Hepatobiliary disposition in primary cultures of dog and monkey hepatocytes
    Kelly A Rose
    Department of Pharmacokinetics, Pharmacodynamics, and Metabolism and Drug Safety Evaluation, Pfizer Global Research and Development, Ann Arbor, Michigan 48105, USA
    Mol Pharm 3:266-74. 2006
    ..The differences observed in taurocholate transport between dog and monkey hepatocytes may be indicative of in vivo species differences...
  11. ncbi request reprint In vitro ADME phenotyping in drug discovery: current challenges and future solutions
    J Andrew Williams
    Pfizer Global Research and Development, Pharmacokinetics, Dynamics and Metabolism, Ann Arbor, MI 48103, USA
    Curr Opin Drug Discov Devel 8:78-88. 2005
    ....
  12. ncbi request reprint Use of in vitro transporter assays to understand hepatic and renal disposition of new drug candidates
    Jasminder Sahi
    CELLZDIRECT, 480 Hillsboro Street, Pittsboro, NC 27312, USA
    Expert Opin Drug Metab Toxicol 1:409-27. 2005
    ....
  13. pmc Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical
    Michael Sinz
    Bristol Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, USA
    AAPS J 10:391-400. 2008
    ..Finally, transgenic animal models and the cynomolgus monkey have also been shown to recapitulate human enzyme induction and may be appropriate in vivo animal models for predicting human drug interactions...