H Rollema

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation
    H Rollema
    Pfizer Inc, Department of Neuroscience, Groton, CT 06340, USA
    Eur J Pharmacol 338:R3-5. 1997
  2. ncbi request reprint Do 5-HT1B/1D autoreceptors modulate dorsal raphe cell firing? In vivo electrophysiological studies in guinea pigs with GR127935
    J Sprouse
    Pfizer Central Research, Groton, CT 06340, USA
    Neuropharmacology 36:559-67. 1997
  3. pmc Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence
    H Rollema
    Neuroscience Biology, Groton, CT 06340, USA
    Br J Pharmacol 160:334-45. 2010
  4. ncbi request reprint Activation of postsynaptic 5-HT(1A) receptors by fluoxetine despite the loss of firing-dependent serotonergic input: electrophysiological and neurochemical studies
    J Sprouse
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Synapse 41:49-57. 2001
  5. ncbi request reprint Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain
    D E Johnson
    Department of Neuroscience, Pfizer Global Research and Development, MS 8220-4159, Groton, CT 06340, USA
    Eur J Pharmacol 425:203-10. 2001
  6. ncbi request reprint Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid
    H Rollema
    Department of Neuroscience Biology, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Neuropharmacology 52:985-94. 2007

Detail Information

Publications6

  1. ncbi request reprint Clozapine increases dopamine release in prefrontal cortex by 5-HT1A receptor activation
    H Rollema
    Pfizer Inc, Department of Neuroscience, Groton, CT 06340, USA
    Eur J Pharmacol 338:R3-5. 1997
    ..Agonist affinity for 5-HT1A receptors could thus be a desirable feature in the design of new antipsychotics...
  2. ncbi request reprint Do 5-HT1B/1D autoreceptors modulate dorsal raphe cell firing? In vivo electrophysiological studies in guinea pigs with GR127935
    J Sprouse
    Pfizer Central Research, Groton, CT 06340, USA
    Neuropharmacology 36:559-67. 1997
    ....
  3. pmc Pre-clinical properties of the alpha4beta2 nicotinic acetylcholine receptor partial agonists varenicline, cytisine and dianicline translate to clinical efficacy for nicotine dependence
    H Rollema
    Neuroscience Biology, Groton, CT 06340, USA
    Br J Pharmacol 160:334-45. 2010
    ..This work examines the origin of the differences by taking into account brain exposure and pharmacological effects at human alpha4beta2 nAChRs...
  4. ncbi request reprint Activation of postsynaptic 5-HT(1A) receptors by fluoxetine despite the loss of firing-dependent serotonergic input: electrophysiological and neurochemical studies
    J Sprouse
    Pfizer Global Research and Development, Groton, Connecticut 06340, USA
    Synapse 41:49-57. 2001
    ....
  5. ncbi request reprint Serotonergic effects and extracellular brain levels of eletriptan, zolmitriptan and sumatriptan in rat brain
    D E Johnson
    Department of Neuroscience, Pfizer Global Research and Development, MS 8220-4159, Groton, CT 06340, USA
    Eur J Pharmacol 425:203-10. 2001
    ....
  6. ncbi request reprint Pharmacological profile of the alpha4beta2 nicotinic acetylcholine receptor partial agonist varenicline, an effective smoking cessation aid
    H Rollema
    Department of Neuroscience Biology, Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Neuropharmacology 52:985-94. 2007
    ..Based on these findings, varenicline was advanced into clinical development and recently shown to be an effective and safe aid for smoking cessation treatment...