- Repeated estradiol treatment prevents MPTP-induced dopamine depletion in male miceAndres D Ramirez
CNS Discovery, Pfizer Global Research and Development, Groton, Conn, USA
Neuroendocrinology 77:223-31. 2003..In this study, raloxifene failed to mimic the neuroprotective effect of 17beta-estradiol against MPTP toxicity. Thus, exploration of new compounds with different pharmacological and/or physiochemical properties is warranted...
- Pramipexole inhibits MPTP toxicity in mice by dopamine D3 receptor dependent and independent mechanismsAndres D Ramirez
CNS Discovery, Pfizer Global Research and Development, MS 8220-4130, Eastern Point Road-Bldg 100, Groton, CT 06340, USA
Eur J Pharmacol 475:29-35. 2003..These results indicate that pramipexole protects dopamine neurons from MPTP-induced toxicity by mechanisms that are both dependent and independent of an interaction with dopamine D3 receptors...
- Role of estrogen receptors in neuroprotection by estradiol against MPTP toxicityMarc Morissette
Molecular Endocrinology and Oncology Research Center, Laval University Medical Center, Quebec City, QC, Canada
Neuropharmacology 52:1509-20. 2007..These results show a greater susceptibility to MPTP toxicity of ERKOalpha mice compared to WT and ERKObeta mice and a role for both ER receptors in striatal DA neuroprotection...