Zaher Radi

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. pmc Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model
    Zaher A Radi
    Drug Safety Research and Development, Pfizer Global Research and Development, 2800 Plymouth Road, Building 50 G0503, Ann Arbor, MI 48105, USA
    Mediators Inflamm 2007:85091. 2007
  2. pmc Lip salivary-gland hamartoma in a cynomolgus macaque (Macaca fascicularis)
    Zaher A Radi
    Pfizer Worldwide Research and Development, Drug Safety Research and Development, Andover, Massachusetts, USA
    Comp Med 64:68-70. 2014
  3. ncbi request reprint Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma
    Zaher Radi
    Pfizer Worldwide Research and Development, Drug Safety R and D, 1 Burtt Rd, Andover, MA 01810, USA Electronic address
    Toxicol Appl Pharmacol 273:456-63. 2013
  4. doi request reprint Renal pathophysiologic role of cortical tubular inclusion bodies
    Zaher A Radi
    Pfizer Worldwide Research and Development, Drug Safety R and D, Cambridge, MA 02140, USA
    Toxicol Pathol 41:32-7. 2013
  5. doi request reprint Human safety risk assessment of lymph node angiomas observed in 2-year carcinogenicity studies in rats
    Zaher A Radi
    Pfizer Worldwide Research and Development, Drug Safety R and D, Cambridge, MA 02140, USA
    Regul Toxicol Pharmacol 64:435-41. 2012
  6. ncbi request reprint Pathophysiology of cyclooxygenase inhibition in animal models
    Zaher A Radi
    Pfizer Global R and D, Drug Safety R and D, St Louis, Missouri 63017, USA
    Toxicol Pathol 37:34-46. 2009
  7. doi request reprint Canine cardiac rhabdomyoma
    Zaher A Radi
    Pfizer Global R and D, Drug Safety R and D, St Louis, Missouri 63017, USA
    Toxicol Pathol 37:348-50. 2009
  8. pmc Increased connective tissue extracellular matrix in the op/op model of osteopetrosis
    Zaher A Radi
    Pfizer Global Research and Development, Drug Safety Research and Development, St Louis, MO 63017, USA
    Pathobiology 76:199-203. 2009
  9. doi request reprint Cellular expression of renal, cardiac and pulmonary inducible nitric oxide synthase in double-transgenic mice expressing human renin and angiotensinogen genes
    Zaher A Radi
    Drug Safety Research and Development, Pfizer Global Research and Development, St Louis, Misouri 63017, USA
    Clin Exp Pharmacol Physiol 36:571-5. 2009
  10. pmc Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection
    Zaher A Radi
    Drug Safety Research and Development, Pfizer Global Research and Development, St Louis Laboratories, St Louis, Missouri 63017, USA
    Viral Immunol 23:43-8. 2010

Detail Information

Publications29

  1. pmc Pulmonary and cardiorenal cyclooxygenase-1 (COX-1), -2 (COX-2), and microsomal prostaglandin E synthase-1 (mPGES-1) and -2 (mPGES-2) expression in a hypertension model
    Zaher A Radi
    Drug Safety Research and Development, Pfizer Global Research and Development, 2800 Plymouth Road, Building 50 G0503, Ann Arbor, MI 48105, USA
    Mediators Inflamm 2007:85091. 2007
    ....
  2. pmc Lip salivary-gland hamartoma in a cynomolgus macaque (Macaca fascicularis)
    Zaher A Radi
    Pfizer Worldwide Research and Development, Drug Safety Research and Development, Andover, Massachusetts, USA
    Comp Med 64:68-70. 2014
    ..To our knowledge, this case description is the first report of a cynomolgus macaque with the rare entity of lip salivary gland hamartoma, which likely represents adenomatous hyperplasia in humans. ..
  3. ncbi request reprint Comparative pathophysiology, toxicology, and human cancer risk assessment of pharmaceutical-induced hibernoma
    Zaher Radi
    Pfizer Worldwide Research and Development, Drug Safety R and D, 1 Burtt Rd, Andover, MA 01810, USA Electronic address
    Toxicol Appl Pharmacol 273:456-63. 2013
    ..Hibernomas observed to date in carcinogenicity studies of pharmaceutical agents do not appear to be relevant for human risk at therapeutic dosages. ..
  4. doi request reprint Renal pathophysiologic role of cortical tubular inclusion bodies
    Zaher A Radi
    Pfizer Worldwide Research and Development, Drug Safety R and D, Cambridge, MA 02140, USA
    Toxicol Pathol 41:32-7. 2013
    ..Such drug-induced renal inclusion bodies are rat-specific, do not represent an expression of nephrotoxicity, represent altered metabolism of d-amino acids, and are not relevant to human safety risk assessment...
  5. doi request reprint Human safety risk assessment of lymph node angiomas observed in 2-year carcinogenicity studies in rats
    Zaher A Radi
    Pfizer Worldwide Research and Development, Drug Safety R and D, Cambridge, MA 02140, USA
    Regul Toxicol Pharmacol 64:435-41. 2012
    ..Mesenteric lymph node angiomas in rats are unlikely to be relevant for human risk assessment of pharmaceutical agents...
  6. ncbi request reprint Pathophysiology of cyclooxygenase inhibition in animal models
    Zaher A Radi
    Pfizer Global R and D, Drug Safety R and D, St Louis, Missouri 63017, USA
    Toxicol Pathol 37:34-46. 2009
    ..Certain ophthalmic conditions such as glaucoma and keratitis are associated with increased COX-2 expression, suggesting a potential role in their pathophysiology...
  7. doi request reprint Canine cardiac rhabdomyoma
    Zaher A Radi
    Pfizer Global R and D, Drug Safety R and D, St Louis, Missouri 63017, USA
    Toxicol Pathol 37:348-50. 2009
    ..Cardiac rhabdomyoma is one of the most frequently occurring primary tumors of the heart and, by far, the most common neoplasm in human infants and children. To our knowledge, this is the first report of the canine cardiac rhabdomyoma...
  8. pmc Increased connective tissue extracellular matrix in the op/op model of osteopetrosis
    Zaher A Radi
    Pfizer Global Research and Development, Drug Safety Research and Development, St Louis, MO 63017, USA
    Pathobiology 76:199-203. 2009
    ..This work suggests an increased ECM that is composed mainly of GAGs located in the subcutaneous tissue in op/op mice. This increase in ECM may be related to altered matrix production or turnover because of changes in M-CSF production...
  9. doi request reprint Cellular expression of renal, cardiac and pulmonary inducible nitric oxide synthase in double-transgenic mice expressing human renin and angiotensinogen genes
    Zaher A Radi
    Drug Safety Research and Development, Pfizer Global Research and Development, St Louis, Misouri 63017, USA
    Clin Exp Pharmacol Physiol 36:571-5. 2009
    ..4. In conclusion, iNOS regulation in hypertension is complex and depends on the cell type in which it is expressed and the localization of the cell type in the cardiorenal and pulmonary systems...
  10. pmc Pulmonary cyclooxygenase-1 (COX-1) and COX-2 cellular expression and distribution after respiratory syncytial virus and parainfluenza virus infection
    Zaher A Radi
    Drug Safety Research and Development, Pfizer Global Research and Development, St Louis Laboratories, St Louis, Missouri 63017, USA
    Viral Immunol 23:43-8. 2010
    ....
  11. ncbi request reprint Bilateral dystrophic calcinosis circumscripta in a cynomolgus macaque (Macaca fascicularis)
    Zaher A Radi
    Pfizer Research and Development, Drug Safety R and D, Cambridge, Massachusetts 02140, USA
    Toxicol Pathol 38:637-41. 2010
    ..To the best of the authors' knowledge, this is the first report of dystrophic calcinosis circumscripta in a cynomolgus macaque...
  12. doi request reprint Development and characterization of a JAK-2-specific antibody suitable for immunohistochemical investigative studies
    Zaher Radi
    Pfizer Research and Development, Drug Safety Research and Development, Cambridge, MA, USA
    Appl Immunohistochem Mol Morphol 19:41-7. 2011
    ..In conclusion, we show the development and characterization of a JAK-2-specific antibody that can be used in investigative and mechanistic studies such as preclinical efficacy models...
  13. pmc Increased serum enzyme levels associated with kupffer cell reduction with no signs of hepatic or skeletal muscle injury
    Zaher A Radi
    Department of Biotherapeutics Research and Development, Pfizer Worldwide Research and Development, Cambridge, MA 02140, USA
    Am J Pathol 179:240-7. 2011
    ..Together, these findings support a mechanism for increases in serum enzyme levels through M-CSF regulation of tissue macrophage homeostasis without concomitant histopathological changes in either the hepatic or skeletal system...
  14. doi request reprint The pathophysiologic role of cyclo-oxygenases in the eye
    Zaher A Radi
    Drug Safety Research and Development, Pfizer Global Research and Development, Chesterfield, MO 63017, USA
    J Ocul Pharmacol Ther 24:141-51. 2008
    ....
  15. ncbi request reprint Effects of cyclooxygenase inhibition on the gastrointestinal tract
    Zaher A Radi
    Worldwide Safety Sciences, Michigan Laboratories, Pfizer Global Research and Development, Building 35 1A 5, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Exp Toxicol Pathol 58:163-73. 2006
    ..In this review, we evaluate available literature describing the pathophysiologic role of cyclooxygenases and the effects of their inhibition in GI system in experimental and domestic animal species...
  16. ncbi request reprint Comparative expression and distribution of c-fos, estrogen receptoralpha (eralpha), and p38alpha in the uterus of rats, monkeys, and humans
    Zaher A Radi
    Worldwide Safety Sciences, Pfizer Global Research and Development, Ann Arbor, Michigan, 48105, USA
    Toxicol Pathol 34:327-35. 2006
    ....
  17. ncbi request reprint Auricular rhabdomyosarcoma in a rat
    Z A Radi
    Pfizer Global R and D, Safety Sciences, Ann Arbor, MI 48105, USA
    J Vet Med A Physiol Pathol Clin Med 53:246-8. 2006
    ..Although reported infrequently in human, this is, to the author's knowledge, the first report that describes the detailed gross, histopathological, histochemical and immunohistochemical findings of auricular rhabdomyosarcoma in a rat...
  18. ncbi request reprint Effects of cyclooxygenase inhibition on bone, tendon, and ligament healing
    Z A Radi
    Safety Sciences, Pfizer Global Research and Development, Building 35 191, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    Inflamm Res 54:358-66. 2005
    ..Collectively, this assessment suggests potential involvement of PGs in the healing process of these tissues via modulation by non-selective NSAIDs and selective COX-2 inhibitors...
  19. ncbi request reprint Renal (uremic) encephalopathy in a goat
    Z A Radi
    Pfizer Global R and D, 2800 Plymouth Road, Building 35 191, Ann Arbor, MI 48105, USA
    J Vet Med A Physiol Pathol Clin Med 52:397-400. 2005
    ..The kidneys had diffuse severe tubular and glomerular necrosis and degeneration. The neural lesions are consistent with renal (uremic) encephalopathy. To the authors' knowledge, this is the first report of renal encephalopathy in a goat...
  20. doi request reprint Pharmacologic evaluation of sulfasalazine, FTY720, and anti-IL-12/23p40 in a TNBS-induced Crohn's disease model
    Zaher A Radi
    Drug Safety R and D, Pfizer Worldwide Research and Development, 35 CambridgePark Dr, Cambridge, MA 02140, USA
    Dig Dis Sci 56:2283-91. 2011
    ..However, published data on pharmacologic and therapeutic efficacy testing of this model are limited. FTY720 inhibits lymphoid cell trafficking in inflammatory conditions and is of interest to treat IBD...
  21. ncbi request reprint Chronic lymphocytic thyroiditis in a cynomolgus macaque (Macaca fascicularis)
    Roberto E Guzman
    Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Toxicol Pathol 35:296-9. 2007
    ..Chronic lymphocytic thyroiditis with compensatory pituitary changes may occur spontaneously in young, clinically normal cynomolgus macaques and its presence in drug treated animals should be interpreted with caution...
  22. ncbi request reprint Endometritis and cystic endometrial hyperplasia in a goat
    Zaher A Radi
    Pfizer Global R and D, Safety Sciences, Building 35 191, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
    J Vet Diagn Invest 17:393-5. 2005
    ..The endometrium was markedly expanded by many irregular cystic and hyperplastic glands. This is the first case report of endometritis and cystic endometrial hyperplasia in a goat in North America...
  23. ncbi request reprint Characterization of age- and gender-related changes in the spleen and thymus from control cynomolgus macaques used in toxicity studies
    Melanie S Spoor
    Colorado State University, Fort Collins, Colorado, USA
    Toxicol Pathol 36:695-704. 2008
    ..The cortex-to-medulla ratio was significantly lower only in males in the seven-to-fifteen-years age group. B- and T-cell cellular density did not change across various ages...
  24. ncbi request reprint Expression of Ki-67 in the uterus during various stages of the estrous cycle in rats
    Rosemary A Marusak
    Michigan State University, East Lansing, MI, USA
    Exp Toxicol Pathol 59:151-5. 2007
    ..This work demonstrates that in the rodent uterus there are cyclic changes in cellular proliferation in specific microanatomic uterine locations which can aid in the staging of the estrous cycle...
  25. ncbi request reprint Fatal West Nile virus infection in a white-tailed deer (Odocoileus virginianus)
    Debra L Miller
    The University of Georgia, College of Veterinary Medicine, Veterinary Diagnostic and Investigational Laboratory, 43 Brighton Road, Tifton, Georgia 31793 1389, USA
    J Wildl Dis 41:246-9. 2005
    ..A reverse transcription-polymerase chain reaction test performed on brain yielded a positive result for West Nile virus. This represents the first report of fatal West Nile virus infection in a white-tailed deer...
  26. ncbi request reprint Cutaneous and pulmonary mycosis in green anacondas (Euncectes murinus)
    Debra L Miller
    Veterinary Diagnostic and Investigational Laboratory, College of Veterinary Medicine, The University of Georgia, Tifton, Georgia 31793 1389, USA
    J Zoo Wildl Med 35:557-61. 2004
    ..Mycotic diseases can be devastating to reptiles, and suboptimal husbandry and captivity were likely the predisposing factors that led to opportunistic invasion in these snakes...
  27. ncbi request reprint Prunus spp. intoxication in ruminants: a case in a goat and diagnosis by identification of leaf fragments in rumen contents
    Zaher A Radi
    Tifton Diagnostic and Investigational Laboratory, College of Veterinary Medicine, The University of Georgia, Tifton, GA 31793 1389, USA
    J Vet Diagn Invest 16:593-9. 2004
    ..in eastern North America: black cherry, Carolina laurel cherry, peach, English laurel cherry, choke cherry, and fire cherry...
  28. ncbi request reprint Renal subcapsular hematoma associated with brodifacoum toxicosis in a dog
    Zaher A Radi
    Tifton Diagnostic and Investigational Laboratory, The University of Georgia, PO Box 1389, Tifton, GA 31793 1389, USA
    Vet Hum Toxicol 46:83-4. 2004
    ..Renal subcapsular hematoma is a well known, but uncommon condition in man. To the authors' knowledge, this is the first report of a brodifacoum-associated renal subcapsular hematoma in a non-human species...