V M Paralkar

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)
    Yin Lin
    Virginia Mason Research Center, 1201 Ninth Ave, Seattle WA 98101, USA
    BMC Cell Biol 3:15. 2002
  2. ncbi An EP2 receptor-selective prostaglandin E2 agonist induces bone healing
    V M Paralkar
    Pfizer Global Research and Development, Groton Laboratories, CT 06340, USA
    Proc Natl Acad Sci U S A 100:6736-40. 2003
  3. ncbi Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family
    V M Paralkar
    Department of Metabolic Diseases, Central Research Division, Pfizer, Inc, Groton, Connecticut 06340, USA
    J Biol Chem 273:13760-7. 1998
  4. ncbi Regulation of BMP-7 expression by retinoic acid and prostaglandin E(2)
    V M Paralkar
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Pfizer, Inc, Groton, Connecticut 06340, USA
    J Cell Physiol 190:207-17. 2002
  5. ncbi Effects of gestational age on prostaglandin EP receptor expression and functional involvement during in vitro contraction of the guinea pig uterus
    K K Terry
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Prostaglandins Leukot Essent Fatty Acids 78:3-10. 2008
  6. ncbi Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models
    H Z Ke
    Department of Cardiovascular and Metabolic Diseases, Pfizer Inc, Groton, Connecticut 06340, USA
    Endocrinology 139:2068-76. 1998
  7. ncbi BMP-6 exerts its osteoinductive effect through activation of IGF-I and EGF pathways
    W A Grasser
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA
    Int Orthop 31:759-65. 2007
  8. ncbi Prostaglandin E(2) receptors in bone formation
    M Li
    Pfizer Global Research and Development, Groton Laboratories, Mail Stop 8118W 208, Groton, CT, 06340, USA
    Int Orthop 31:767-72. 2007
  9. ncbi Prostaglandin E2 receptor subtype EP-2 is not involved in the induction of non-pregnant guinea pig uterine contractions associated with terminal pregnancy
    Wes Lebel
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Prostaglandins Leukot Essent Fatty Acids 71:399-404. 2004
  10. ncbi Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure
    S Vukicevic
    Laboratory of Mineralized Tissues, Department of Anatomy, Zagreb Medical School, University of Zagreb, Zagreb, Croatia
    Kidney Int 70:1099-106. 2006

Collaborators

Detail Information

Publications11

  1. ncbi A novel link between the proteasome pathway and the signal transduction pathway of the bone morphogenetic proteins (BMPs)
    Yin Lin
    Virginia Mason Research Center, 1201 Ninth Ave, Seattle WA 98101, USA
    BMC Cell Biol 3:15. 2002
    ..SNIP1 is a recently discovered novel repressor of CBP/p300. Currently, the detailed molecular mechanisms that allow R-Smads and Co-Smad to co-operatively modulate transcription events are not fully understood...
  2. ncbi An EP2 receptor-selective prostaglandin E2 agonist induces bone healing
    V M Paralkar
    Pfizer Global Research and Development, Groton Laboratories, CT 06340, USA
    Proc Natl Acad Sci U S A 100:6736-40. 2003
    ..The potent bone anabolic activity of CP-533,536 offers a therapeutic alternative for the treatment of fractures and bone defects in patients...
  3. ncbi Cloning and characterization of a novel member of the transforming growth factor-beta/bone morphogenetic protein family
    V M Paralkar
    Department of Metabolic Diseases, Central Research Division, Pfizer, Inc, Groton, Connecticut 06340, USA
    J Biol Chem 273:13760-7. 1998
    ..In addition, subcutaneous implantation of recombinant PDF induced cartilage formation and the early stages of endochondral bone formation. These data indicate that PDF has a functional relationship to the BMPs...
  4. ncbi Regulation of BMP-7 expression by retinoic acid and prostaglandin E(2)
    V M Paralkar
    Department of Cardiovascular and Metabolic Diseases, Pfizer Global Research and Development, Pfizer, Inc, Groton, Connecticut 06340, USA
    J Cell Physiol 190:207-17. 2002
    ..Additionally, in vivo expression of BMP-7 in bone was increased upon PGE(2) treatment. In conclusion, RA and PGE(2) upregulate BMP-7 protein expression both in vitro and in vivo...
  5. ncbi Effects of gestational age on prostaglandin EP receptor expression and functional involvement during in vitro contraction of the guinea pig uterus
    K K Terry
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Prostaglandins Leukot Essent Fatty Acids 78:3-10. 2008
    ..CP-533,536--a highly selective EP2 receptor agonist--and the vehicle failed to induce myometrial contraction at both gestational ages...
  6. ncbi Effects of CP-336,156, a new, nonsteroidal estrogen agonist/antagonist, on bone, serum cholesterol, uterus and body composition in rat models
    H Z Ke
    Department of Cardiovascular and Metabolic Diseases, Pfizer Inc, Groton, Connecticut 06340, USA
    Endocrinology 139:2068-76. 1998
    ..In summary, CP-336,156 is a new, orally active, nonsteroidal, potent estrogen agonist/antagonist that has similar effects in bone as estradiol but without the uterine-stimulating effects associated with estradiol in rats...
  7. ncbi BMP-6 exerts its osteoinductive effect through activation of IGF-I and EGF pathways
    W A Grasser
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT, 06340, USA
    Int Orthop 31:759-65. 2007
    ..These results collectively indicate that BMP-6 exerts its osteoinductive effect, at least in part, through IGF-I and EGF pathways, which can be observed both in a murine model of osteopenia and in human osteoblasts...
  8. ncbi Prostaglandin E(2) receptors in bone formation
    M Li
    Pfizer Global Research and Development, Groton Laboratories, Mail Stop 8118W 208, Groton, CT, 06340, USA
    Int Orthop 31:767-72. 2007
    ..This review will focus on the studies related to bone formation and bone healing in the EP receptor knockout (KO) mice and the EP2 or EP4 receptor-selective agonist treated animal models...
  9. ncbi Prostaglandin E2 receptor subtype EP-2 is not involved in the induction of non-pregnant guinea pig uterine contractions associated with terminal pregnancy
    Wes Lebel
    Pfizer Global Research and Development, Groton Laboratories, Eastern Point Road, Groton, CT 06340, USA
    Prostaglandins Leukot Essent Fatty Acids 71:399-404. 2004
    ..Further, CP-533,536 did not antagonize the ability of PGE2 to induce uterine contractions in this model...
  10. ncbi Role of EP2 and EP4 receptor-selective agonists of prostaglandin E(2) in acute and chronic kidney failure
    S Vukicevic
    Laboratory of Mineralized Tissues, Department of Anatomy, Zagreb Medical School, University of Zagreb, Zagreb, Croatia
    Kidney Int 70:1099-106. 2006
    ..Thus, agonism of EP2 and EP4 receptors may provide a basis for treating acute and chronic kidney failure...
  11. ncbi Interaction of osteogenin, a heparin binding bone morphogenetic protein, with type IV collagen
    V M Paralkar
    Bone Cell Biology Section, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20892
    J Biol Chem 265:17281-4. 1990
    ..These results imply that osteogenin binding to extracellular matrix components including collagens I and IV and heparin may have physiological relevance, and such interactions may modulate its local action...