Paul J Pagano
Affiliation: Pfizer Global Research and Development
- Effects of linezolid on staphylococcal adherence versus time of treatmentPaul J Pagano
Pfizer Kalamazoo, MI 49007, USA
Int J Antimicrob Agents 23:226-34. 2004..Linezolid has promising in vitro anti-adhesion activity that merits further studies to determine its role in the management of foreign-body infections...
- Synthesis and structure-activity studies of novel homomorpholine oxazolidinone antibacterial agentsJi Young Kim
Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
Bioorg Med Chem Lett 19:550-3. 2009..Various C-5 functional groups were also examined, including acetamides and triazoles and carboxamides...
- Efficacy of linezolid plus rifampin in an experimental model of methicillin-susceptible Staphylococcus aureus endocarditisCharlene F Dailey
Pharmacology, Pfizer, Kalamazoo, Michigan 49001, USA
Antimicrob Agents Chemother 47:2655-8. 2003..The results from this experimental model of endocarditis suggest that while rifampin did not provide synergy to the linezolid dosing, it did not antagonize the efficacy of linezolid...
- Antibacterial oxazolidinones possessing a novel C-5 side chain. (5R)-trans-3-[3-Fluoro-4- (1-oxotetrahydrothiopyran-4-yl)phenyl]-2- oxooxazolidine-5-carboxylic acid amide (PF-00422602), a new lead compoundToni Jo Poel
Michigan Laboratories, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, MI 48105, USA
J Med Chem 50:5886-9. 2007..The title compound (14) showed reduced in vivo myelotoxicity compared to linezolid in a 14-day safety study in rats, potent in vivo efficacy in murine systemic infection models, and excellent pharmacokinetic properties...