Margot O'Toole

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. pmc Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood
    Unnur S Bjornsdottir
    Department of Allergy Clinical Immunology, University of Iceland, Reykjavik, Iceland
    PLoS ONE 6:e21902. 2011
  2. pmc The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls
    Marcus Ronninger
    Department of Medicine, Rheumatology Unit, CMM L8 04, Karolinska Institutet and Karolinska Universitetssjukhuset, Stockholm, S 17176, Sweden
    Genome Med 4:2. 2012
  3. pmc Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody
    Yongjing Guo
    Pfizer, BioTherapeutics Clinical Translational Medicine, Cambridge, MA, USA
    J Transl Med 8:50. 2010
  4. pmc Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood
    Maya Arai
    Global Biotherapeutic Technologies, Pfizer, Cambridge, MA 02140, USA
    J Transl Med 8:51. 2010
  5. ncbi TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines
    Jun Kuai
    Department of Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Rheumatology (Oxford) 48:1352-8. 2009
  6. ncbi Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells
    Margot O'Toole
    Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    Arch Neurol 62:1531-6. 2005
  7. pmc Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis
    Padmalatha S Reddy
    Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Res Ther 10:R127. 2008
  8. doi Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis
    Yijun Carrier
    Inflammation and Immunology, BioTherapeutic Research, Pfizer, Cambridge, Massachusetts 02140, USA
    J Invest Dermatol 131:2428-37. 2011
  9. pmc Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys
    Yulia Vugmeyster
    Pfizer, Inc, Andover, MA 01810, USA
    J Transl Med 8:41. 2010

Collaborators

Detail Information

Publications9

  1. pmc Pathways activated during human asthma exacerbation as revealed by gene expression patterns in blood
    Unnur S Bjornsdottir
    Department of Allergy Clinical Immunology, University of Iceland, Reykjavik, Iceland
    PLoS ONE 6:e21902. 2011
    ..This study was conducted to determine if mRNA profiling of peripheral blood mononuclear cells (PBMCs) could provide information on the systemic molecular pathways involved during asthma exacerbations...
  2. pmc The balance of expression of PTPN22 splice forms is significantly different in rheumatoid arthritis patients compared with controls
    Marcus Ronninger
    Department of Medicine, Rheumatology Unit, CMM L8 04, Karolinska Institutet and Karolinska Universitetssjukhuset, Stockholm, S 17176, Sweden
    Genome Med 4:2. 2012
    ....
  3. pmc Assessing agonistic potential of a candidate therapeutic anti-IL21R antibody
    Yongjing Guo
    Pfizer, BioTherapeutics Clinical Translational Medicine, Cambridge, MA, USA
    J Transl Med 8:50. 2010
    ..abstract:..
  4. pmc Development and application of a biomarker assay for determining the pharmacodynamic activity of an antagonist candidate biotherapeutic antibody to IL21R in whole blood
    Maya Arai
    Global Biotherapeutic Technologies, Pfizer, Cambridge, MA 02140, USA
    J Transl Med 8:51. 2010
    ..This report and a recently published companion report address the first three of these needs. The fourth has been addressed in a separate study...
  5. ncbi TREM-1 expression is increased in the synovium of rheumatoid arthritis patients and induces the expression of pro-inflammatory cytokines
    Jun Kuai
    Department of Inflammation, Wyeth Research, 200 Cambridge Park Drive, Cambridge, MA 02140, USA
    Rheumatology (Oxford) 48:1352-8. 2009
    ..To investigate the expression and function of triggering receptor expressed on myeloid cells-1 (TREM-1) in the synovium of human RA patients as well as the level of soluble TREM-1 in the plasma of RA patients...
  6. ncbi Risk factors associated with beta-amyloid(1-42) immunotherapy in preimmunization gene expression patterns of blood cells
    Margot O'Toole
    Biological Technologies, Wyeth Research, Cambridge, MA 02140, USA
    Arch Neurol 62:1531-6. 2005
    ..Six immunizations were planned but were halted when meningoencephalitis was recognized as an adverse event in 6% of immunized patients...
  7. pmc Mapping similarities in mTOR pathway perturbations in mouse lupus nephritis models and human lupus nephritis
    Padmalatha S Reddy
    Biological Technologies, Wyeth Research, Cambridge, Massachusetts 02140, USA
    Arthritis Res Ther 10:R127. 2008
    ..Therefore, a more profound understanding of the mechanistic similarities and differences between various animal models and human diseases is highly desirable...
  8. doi Inter-regulation of Th17 cytokines and the IL-36 cytokines in vitro and in vivo: implications in psoriasis pathogenesis
    Yijun Carrier
    Inflammation and Immunology, BioTherapeutic Research, Pfizer, Cambridge, Massachusetts 02140, USA
    J Invest Dermatol 131:2428-37. 2011
    ..We propose that a feedback loop between the IL-36 and Th17 cytokines is involved in driving cytokine expression in psoriatic tissues...
  9. pmc Correlation of pharmacodynamic activity, pharmacokinetics, and anti-product antibody responses to anti-IL-21R antibody therapeutics following IV administration to cynomolgus monkeys
    Yulia Vugmeyster
    Pfizer, Inc, Andover, MA 01810, USA
    J Transl Med 8:41. 2010
    ..This study evaluated correlations between the pharmacodynamic (PD) activity, pharmacokinetics, and anti-product antibody responses of human anti-IL-21R antibodies Ab-01 and Ab-02 following IV administration to cynomolgus monkeys...