Liza Leventhal

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. doi request reprint Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231)
    David J O'Neill
    Chemical Sciences, Pfizer Global Research and Development, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 53:4511-21. 2010
  2. doi request reprint Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152)
    David J O'Neill
    Chemical Sciences, Pfizer, 500 Arcola Road, Collegeville, Pennsylvania 19426, United States
    J Med Chem 54:6824-31. 2011
  3. doi request reprint 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors
    An T Vu
    Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 53:2051-62. 2010
  4. ncbi request reprint Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent models
    Darlene C Deecher
    Women s Health and Musculoskeletal Biology, Wyeth Research N3164, 500 Arcola Road, Collegeville, PA 19426, USA
    Endocrinology 148:1376-83. 2007
  5. ncbi request reprint The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models
    Navin Maswood
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, USA
    Neuroendocrinology 84:330-8. 2006
  6. ncbi request reprint Effect of calcium channel modulators on temperature regulation in ovariectomized rats
    Liza Leventhal
    Women s Health Research Institute, Wyeth Research RN3164, 500 Arcola Rd, Collegeville, PA 19426, USA
    Pharmacol Biochem Behav 80:511-20. 2005
  7. doi request reprint Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors
    Paige E Mahaney
    Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 51:4038-49. 2008
  8. ncbi request reprint Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines
    Paige E Mahaney
    Chemical and Screening Sciences, Discovery Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem 14:8455-66. 2006
  9. ncbi request reprint Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction
    Kimberly Sipe
    Women s Health Research Institute, Wyeth Research N3151A, 500 Arcola Rd, Collegeville, PA 19426, USA
    Brain Res 1028:191-202. 2004

Collaborators

Detail Information

Publications9

  1. doi request reprint Discovery of novel selective norepinephrine reuptake inhibitors: 4-[3-aryl-2,2-dioxido-2,1,3-benzothiadiazol-1(3H)-yl]-1-(methylamino)butan-2-ols (WYE-103231)
    David J O'Neill
    Chemical Sciences, Pfizer Global Research and Development, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 53:4511-21. 2010
    ....
  2. doi request reprint Discovery of novel selective norepinephrine inhibitors: 1-(2-morpholin-2-ylethyl)-3-aryl-1,3-dihydro-2,1,3-benzothiadiazole 2,2-dioxides (WYE-114152)
    David J O'Neill
    Chemical Sciences, Pfizer, 500 Arcola Road, Collegeville, Pennsylvania 19426, United States
    J Med Chem 54:6824-31. 2011
    ..10b was additionally bioavailable following oral dosing and demonstrated efficacy in rat models of acute, inflammatory, and neuropathic pain...
  3. doi request reprint 1-(Indolin-1-yl)-1-phenyl-3-propan-2-olamines as potent and selective norepinephrine reuptake inhibitors
    An T Vu
    Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 53:2051-62. 2010
    ....
  4. ncbi request reprint Alleviation of thermoregulatory dysfunction with the new serotonin and norepinephrine reuptake inhibitor desvenlafaxine succinate in ovariectomized rodent models
    Darlene C Deecher
    Women s Health and Musculoskeletal Biology, Wyeth Research N3164, 500 Arcola Road, Collegeville, PA 19426, USA
    Endocrinology 148:1376-83. 2007
    ..These preclinical studies provide evidence that DVS directly impacts thermoregulatory dysfunction in OVX rats and may have utility in alleviating VMS associated with menopause...
  5. ncbi request reprint The role of the selective serotonin reuptake inhibitor fluoxetine in temperature regulation in ovariectomized rat models
    Navin Maswood
    Women s Health and Musculoskeletal Biology, Wyeth Research, Collegeville, PA 19426, USA
    Neuroendocrinology 84:330-8. 2006
    ..c. dose abated the naloxone-induced increase in TST by 55 and 81%, respectively. In summary, FLX affected CBT at all doses, but alleviated thermoregulatory dysfunction only at higher doses that are non-selective for the 5-HT system...
  6. ncbi request reprint Effect of calcium channel modulators on temperature regulation in ovariectomized rats
    Liza Leventhal
    Women s Health Research Institute, Wyeth Research RN3164, 500 Arcola Rd, Collegeville, PA 19426, USA
    Pharmacol Biochem Behav 80:511-20. 2005
    ..The present data suggests that gabapentin, verapamil and nifedipine all act to globally alter temperature regulation in steroid-dependent models of thermoregulatory function...
  7. doi request reprint Structure-activity relationships of the cycloalkanol ethylamine scaffold: discovery of selective norepinephrine reuptake inhibitors
    Paige E Mahaney
    Chemical and Screening Sciences, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA
    J Med Chem 51:4038-49. 2008
    ....
  8. ncbi request reprint Synthesis and activity of a new class of dual acting norepinephrine and serotonin reuptake inhibitors: 3-(1H-indol-1-yl)-3-arylpropan-1-amines
    Paige E Mahaney
    Chemical and Screening Sciences, Discovery Medicinal Chemistry, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA
    Bioorg Med Chem 14:8455-66. 2006
    ....
  9. ncbi request reprint Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction
    Kimberly Sipe
    Women s Health Research Institute, Wyeth Research N3151A, 500 Arcola Rd, Collegeville, PA 19426, USA
    Brain Res 1028:191-202. 2004
    ..These results indicate that activation of central 5-HT(2A) receptors restores temperature regulation in two rodent models of ovariectomy-induced thermoregulatory dysfunction...