Caroline A Lee

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. doi Identification of novel substrates for human cytochrome P450 2J2
    Caroline A Lee
    Pfizer Global Research and Development, 10646 Science Center Dr, San Diego, CA 92121, USA
    Drug Metab Dispos 38:347-56. 2010
  2. doi P-glycoprotein related drug interactions: clinical importance and a consideration of disease states
    Caroline A Lee
    Pfizer Global Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, 10646 Science Center Drive, San Diego, CA 92121, USA
    Expert Opin Drug Metab Toxicol 6:603-19. 2010
  3. ncbi Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A
    Ping Zhao
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla Laboratories, La Jolla, California, USA
    Drug Metab Dispos 35:704-12. 2007
  4. ncbi Evaluation of time-dependent inactivation of CYP3A in cryopreserved human hepatocytes
    Ping Zhao
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla Laboratories, 10724 Science Center Dr, San Diego, CA 92121, USA
    Drug Metab Dispos 33:853-61. 2005

Detail Information

Publications4

  1. doi Identification of novel substrates for human cytochrome P450 2J2
    Caroline A Lee
    Pfizer Global Research and Development, 10646 Science Center Dr, San Diego, CA 92121, USA
    Drug Metab Dispos 38:347-56. 2010
    ..The resulting data suggest that CYP2J2 may be an unrecognized participant in first-pass metabolism, but its contribution is minor relative to that of CYP3A4...
  2. doi P-glycoprotein related drug interactions: clinical importance and a consideration of disease states
    Caroline A Lee
    Pfizer Global Research and Development, Department of Pharmacokinetics, Dynamics and Metabolism, 10646 Science Center Drive, San Diego, CA 92121, USA
    Expert Opin Drug Metab Toxicol 6:603-19. 2010
    ....
  3. ncbi Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A
    Ping Zhao
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla Laboratories, La Jolla, California, USA
    Drug Metab Dispos 35:704-12. 2007
    ..These findings suggest that prediction of CYP3A loss based solely on microsomal inactivation parameters of parent drug may be inadequate...
  4. ncbi Evaluation of time-dependent inactivation of CYP3A in cryopreserved human hepatocytes
    Ping Zhao
    Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, La Jolla Laboratories, 10724 Science Center Dr, San Diego, CA 92121, USA
    Drug Metab Dispos 33:853-61. 2005
    ..In summary, these studies reveal three important factors that must be considered when microsomal inactivation parameters are used to predict inhibition-based drug interactions in intact cell systems...