Lit Fui Lau

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint Cdk5 as a drug target for the treatment of Alzheimer's disease
    Lit Fui Lau
    CNS Discovery, Pfizer Global Research and Development, Groton, CT 06340, USA
    J Mol Neurosci 19:267-73. 2002
  2. ncbi request reprint Tau protein phosphorylation as a therapeutic target in Alzheimer's disease
    Lit Fui Lau
    CNS Discovery, Pfizer Global Research and Development, Groton, CT 06340, USA
    Curr Top Med Chem 2:395-415. 2002
  3. ncbi request reprint Cdk5 is a key factor in tau aggregation and tangle formation in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuron 38:555-65. 2003
  4. ncbi request reprint Role of cdk5 in the pathogenesis of Alzheimer's disease
    Lit Fui Lau
    CNS Discovery, Pfizer Global Research and Development, Groton, Conn 06340, USA
    Neurosignals 12:209-14. 2003
  5. pmc Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:680-90. 2008
  6. ncbi request reprint Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139
    Thomas A Lanz
    Pfizer, Inc, Eastern Point Rd, MS 8220 4183, Groton, CT 06340, USA
    J Pharmacol Exp Ther 319:924-33. 2006
  7. doi request reprint Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 28:2624-32. 2008
  8. ncbi request reprint Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand
    Hee Jung Chung
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:10248-59. 2004
  9. ncbi request reprint Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Cdk5 as a drug target for the treatment of Alzheimer's disease
    Lit Fui Lau
    CNS Discovery, Pfizer Global Research and Development, Groton, CT 06340, USA
    J Mol Neurosci 19:267-73. 2002
    ..Availability of potent, selective, brain permeable cdk5 inhibitors and relevant animal models in which their efficacy can be treated will be critical in the development of these inhibitors...
  2. ncbi request reprint Tau protein phosphorylation as a therapeutic target in Alzheimer's disease
    Lit Fui Lau
    CNS Discovery, Pfizer Global Research and Development, Groton, CT 06340, USA
    Curr Top Med Chem 2:395-415. 2002
    ....
  3. ncbi request reprint Cdk5 is a key factor in tau aggregation and tangle formation in vivo
    Wendy Noble
    Center for Dementia Research, Nathan S Kline Institute, New York University, 140 Old Orangeburg Road, Orangeburg, NY 10962, USA
    Neuron 38:555-65. 2003
    ..Insoluble tau was also associated with active GSK. Thus, cdk5 can initiate a major impact on tau pathology progression that probably involves several kinases. Kinase inhibitors may thus be beneficial therapeutically...
  4. ncbi request reprint Role of cdk5 in the pathogenesis of Alzheimer's disease
    Lit Fui Lau
    CNS Discovery, Pfizer Global Research and Development, Groton, Conn 06340, USA
    Neurosignals 12:209-14. 2003
    ..The mechanisms for this potentially damaging activity of cdk5 are largely unknown although amyloid precursor protein and presenilin-1 are both cdk5 substrates...
  5. pmc Transcriptional regulation of beta-secretase by p25/cdk5 leads to enhanced amyloidogenic processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York, NY 10032, USA
    Neuron 57:680-90. 2008
    ..These data demonstrate a pathway by which p25/cdk5 increases the amyloidogenic processing of APP through STAT3-mediated transcriptional control of BACE1 that could have implications for AD pathogenesis...
  6. ncbi request reprint Concentration-dependent modulation of amyloid-beta in vivo and in vitro using the gamma-secretase inhibitor, LY-450139
    Thomas A Lanz
    Pfizer, Inc, Eastern Point Rd, MS 8220 4183, Groton, CT 06340, USA
    J Pharmacol Exp Ther 319:924-33. 2006
    ..These results suggest that LY-450139 modulates the gamma-secretase complex, eliciting Abeta lowering at high concentrations but Abeta elevation at low concentrations...
  7. doi request reprint Interplay between cyclin-dependent kinase 5 and glycogen synthase kinase 3 beta mediated by neuregulin signaling leads to differential effects on tau phosphorylation and amyloid precursor protein processing
    Yi Wen
    Taub Institute at Columbia University Medical Center, New York State Psychiatric Institute, New York, New York 10032, USA
    J Neurosci 28:2624-32. 2008
    ..Thus, cdk5 inhibitors may not be effective in targeting tau phosphorylation in the elderly...
  8. ncbi request reprint Regulation of the NMDA receptor complex and trafficking by activity-dependent phosphorylation of the NR2B subunit PDZ ligand
    Hee Jung Chung
    Department of Neuroscience, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurosci 24:10248-59. 2004
    ....
  9. ncbi request reprint Anesthesia leads to tau hyperphosphorylation through inhibition of phosphatase activity by hypothermia
    Emmanuel Planel
    Columbia University Medical Center, Department of Pathology, Taub Institute for Alzheimer s Disease Research, New York, New York 10032, USA
    J Neurosci 27:3090-7. 2007
    ..Furthermore, a thorough examination of the effect of anesthesia-induced hypothermia on the risk and progression of AD is warranted...