Affiliation: Pfizer Global Research and Development
Kalgutkar A, Dalvie D, Castagnoli N, Taylor T. Interactions of nitrogen-containing xenobiotics with monoamine oxidase (MAO) isozymes A and B: SAR studies on MAO substrates and inhibitors. Chem Res Toxicol. 2001;14:1139-62 pubmed
Kalgutkar A, Dalvie D, O Donnell J, Taylor T, Sahakian D. On the diversity of oxidative bioactivation reactions on nitrogen-containing xenobiotics. Curr Drug Metab. 2002;3:379-424 pubmed
..Potential strategies that could be utilized in the screening of novel bioactivation pathways are also discussed. ..
Kalgutkar A, Henne K, Lame M, Vaz A, Collin C, Soglia J, et al. Metabolic activation of the nontricyclic antidepressant trazodone to electrophilic quinone-imine and epoxide intermediates in human liver microsomes and recombinant P4503A4. Chem Biol Interact. 2005;155:10-20 pubmed
..It is proposed that the quinone-imine and/or the epoxide intermediate(s) may represent a rate-limiting step in the initiation of trazodone-mediated hepatotoxicity. ..