Research Topics
Species | Kaori ItoSummaryAffiliation: Pfizer Global Research and Development Country: USA Publications
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Detail Information
Publications
Disease progression meta-analysis model in Alzheimer's diseaseKaori Ito
Pfizer Global Research and Development, New London, CT, USA
Alzheimers Dement 6:39-53. 2010..The model was used to estimate disease progression for both placebo-treated patients and acetylcholinesterase (AChE)-inhibitor treated patients, and factors that affected disease progression...
Modeling of Functional Assessment Questionnaire (FAQ) as continuous bounded data from the ADNI databaseK Ito
Pfizer Inc, Primary Care Business Unit, 445 Eastern Point Road, Groton, CT 06340, USA
J Pharmacokinet Pharmacodyn 39:601-18. 2012..The basic method for handling boundary data used in this analysis is also applicable to handle boundary observations for numerous other endpoints...
Assessment of alpha1-adrenoceptor antagonists in benign prostatic hyperplasia based on the receptor occupancy theoryKaori Ito
Medico Pharmaceutical Sciences, Graduate School of Pharmaceutical Sciences, Kyusyu University, Fukuoka, Japan
Br J Clin Pharmacol 63:394-403. 2007....
Disease progression model for cognitive deterioration from Alzheimer's Disease Neuroimaging Initiative databaseKaori Ito
Pfizer Global Research and Development, New London, CT, USA
Alzheimers Dement 7:151-60. 2011..A mathematical model was developed to describe the longitudinal response in Alzheimer's Disease Assessment Scale-cognitive (ADAS-cog) obtained from the Alzheimer's Disease Neuroimaging Initiative...
Effects of standard and supratherapeutic doses of nelfinavir on cardiac repolarization: a thorough QT studyBharat Damle
Pfizer Global Research and Development, Pfizer Inc, 685 Third Ave, 685 13 55, New York, NY 10017, USA
J Clin Pharmacol 49:291-300. 2009..At clinically relevant, doses nelfinavir is unlikely to cause QTc prolongation...
Population pharmacokinetic analysis of linezolid in patients with infectious disease: application to lower body weight and elderly patientsSadahiro Abe
Clinical Pharmacology, Global Research and Development, Tokyo Laboratories, Pfizer, Tokyo, Japan
J Clin Pharmacol 49:1071-8. 2009..The present population PK model of linezolid described well the PK profiles in Japanese patients who have lower BW and are relatively older compared with those in the United States/European Union...
Combining patient-level and summary-level data for Alzheimer's disease modeling and simulation: a beta regression meta-analysisJames A Rogers
Metrum Research Group, Tariffville, CT 06081, USA
J Pharmacokinet Pharmacodyn 39:479-98. 2012..A further advantage of the BR model is that it constrains values to the range of the original instrument for simulation purposes, in contrast to methodologies that provide appropriate constraints only for conditional expectations...
Exposure-response analyses of the effects of pregabalin in patients with fibromyalgia using daily pain scores and patient global impression of changeWonkyung Byon
Clinical Pharmacology, Pfizer Global Research and Development, 50 Pequot Avenue, New London, CT 06320, USA
J Clin Pharmacol 50:803-15. 2010..The analyses support the recommended dose of pregabalin in patients with fibromyalgia of 300 to 450 mg/d...
