Karen L Houseknecht
Affiliation: Pfizer Global Research and Development
- Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effectsKaren L Houseknecht
Department of Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Groton, CT 06340, USA
Neuropsychopharmacology 32:289-97. 2007..OLAN and CLOZ can thus rapidly induce marked insulin resistance, which could contribute to the hyperglycemia and ketoacidosis reported for patients receiving those therapies...
- Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a reviewKaren L Houseknecht
Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
Domest Anim Endocrinol 22:1-23. 2002..Additionally, naturally occurring and pharmaceutical ligands for the receptor as well as the potential role of PPARgamma as the receptor responsible for fatty acid-induced effects on gene expression will be described...
- Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissueKolapo M Ajuwon
Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
J Nutr Biochem 14:576-83. 2003..The regulation of PPARgamma by leptin seems complex in that it varied in relation to dose in vivo, and may be impacted by in vitro vs. in vivo circumstances...
- GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidaseEugenia Carvalho
Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
J Biol Chem 279:21598-605. 2004..Our results show that GLUT4 overexpression or deficiency affects the amount of other GLUT4-vesicle proteins including IRAP and VAMP2 and that GLUT4 sequestration is saturable...