Karen L Houseknecht

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects
    Karen L Houseknecht
    Department of Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Groton, CT 06340, USA
    Neuropsychopharmacology 32:289-97. 2007
  2. ncbi request reprint Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review
    Karen L Houseknecht
    Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Domest Anim Endocrinol 22:1-23. 2002
  3. ncbi request reprint Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue
    Kolapo M Ajuwon
    Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
    J Nutr Biochem 14:576-83. 2003
  4. ncbi request reprint GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase
    Eugenia Carvalho
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    J Biol Chem 279:21598-605. 2004

Collaborators

Detail Information

Publications4

  1. ncbi request reprint Acute effects of atypical antipsychotics on whole-body insulin resistance in rats: implications for adverse metabolic effects
    Karen L Houseknecht
    Department of Cardiovascular, Metabolic and Endocrine Diseases, Pfizer Global Research and Development, Groton, CT 06340, USA
    Neuropsychopharmacology 32:289-97. 2007
    ..OLAN and CLOZ can thus rapidly induce marked insulin resistance, which could contribute to the hyperglycemia and ketoacidosis reported for patients receiving those therapies...
  2. ncbi request reprint Peroxisome proliferator-activated receptor gamma (PPARgamma) and its ligands: a review
    Karen L Houseknecht
    Pfizer Global Research and Development, Eastern Point Road, Groton, CT 06340, USA
    Domest Anim Endocrinol 22:1-23. 2002
    ..Additionally, naturally occurring and pharmaceutical ligands for the receptor as well as the potential role of PPARgamma as the receptor responsible for fatty acid-induced effects on gene expression will be described...
  3. ncbi request reprint Chronic leptin administration increases serum NEFA in the pig and differentially regulates PPAR expression in adipose tissue
    Kolapo M Ajuwon
    Department of Animal Sciences, Purdue University, West Lafayette, IN, USA
    J Nutr Biochem 14:576-83. 2003
    ..The regulation of PPARgamma by leptin seems complex in that it varied in relation to dose in vivo, and may be impacted by in vitro vs. in vivo circumstances...
  4. ncbi request reprint GLUT4 overexpression or deficiency in adipocytes of transgenic mice alters the composition of GLUT4 vesicles and the subcellular localization of GLUT4 and insulin-responsive aminopeptidase
    Eugenia Carvalho
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, 99 Brookline Avenue, Boston, MA 02215, USA
    J Biol Chem 279:21598-605. 2004
    ..Our results show that GLUT4 overexpression or deficiency affects the amount of other GLUT4-vesicle proteins including IRAP and VAMP2 and that GLUT4 sequestration is saturable...