- Can we rationally design promiscuous drugs?Andrew L Hopkins
Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
Curr Opin Struct Biol 16:127-36. 2006..By combining advances in chemoinformatics and structural biology, it might be possible to rationally design the next generation of promiscuous drugs with polypharmacology...
- Global mapping of pharmacological spaceGaia V Paolini
The Department of Knowledge Discovery, Pfizer Global Research and Development, Sandwich, Kent CT13 9NJ, UK
Nat Biotechnol 24:805-15. 2006..The relationships between proteins, chemical structures and drug-like properties provide a framework for developing a probabilistic approach to drug discovery that can be exploited to increase research productivity...