Affiliation: Pfizer Global Research and Development
Hope H, Anderson G, Burnette B, Compton R, Devraj R, Hirsch J, et al. Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translation. J Pharmacol Exp Ther. 2009;331:882-95 pubmed publisher
..In addition, a direct correspondence between p38 MAP kinase inhibition and anti-inflammatory activity was observed with PH-797804, thus providing confidence in dose projections for further human studies in chronic inflammatory disease. ..