Heidi R Hope
Affiliation: Pfizer Global Research and Development
- Anti-inflammatory properties of a novel N-phenyl pyridinone inhibitor of p38 mitogen-activated protein kinase: preclinical-to-clinical translationHeidi R Hope
Discovery Biology, Inflammation Research, Pfizer Global Research and Development, Chesterfield, Missouri 63017, USA
J Pharmacol Exp Ther 331:882-95. 2009..In addition, a direct correspondence between p38 MAP kinase inhibition and anti-inflammatory activity was observed with PH-797804, thus providing confidence in dose projections for further human studies in chronic inflammatory disease...
- Structural bioinformatics-based prediction of exceptional selectivity of p38 MAP kinase inhibitor PH-797804Li Xing
Structural and Computational Chemistry, St Louis Laboratories, Pfizer Global Research and Development, 700 Chesterfield Parkway West, Chesterfield, Missouri 63017, USA
Biochemistry 48:6402-11. 2009..Understanding the rationale for selectivity at the molecular level helps elucidate the biological function and design of specific p38alpha kinase inhibitors...
- Interleukin-1β-induced interleukin-6 production in A549 cells is mediated by both phosphatidylinositol 3-kinase and interleukin-1 receptor-associated kinase-4Hiroyuki Eda
Discovery Biology, Global Research and Development, St Louis Laboratories Pfizer Inc, 700 Chesterfield Parkway West, Chesterfield, MO 63017, USA
Cell Biol Int 35:355-8. 2011..These results indicate that IL-1β-induced IL-6 production in A549 cells is mediated by both PI3K and IRAK4 and suggest that involvement of PI3K in the IL-1-induced IL-6 production is cell type specific...