Marie Pierre Hellio Le Graverand

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. doi request reprint OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed?
    M P Hellio Le Graverand-Gastineau
    Pfizer Global Research and Development, 50 Pequot Avenue, New London, 06320 CT, USA
    Osteoarthritis Cartilage 17:1393-401. 2009
  2. doi request reprint Considerations when designing a disease-modifying osteoarthritis drug (DMOAD) trial using radiography
    Marie Pierre Hellio Le Graverand
    Pfizer Inc, Primary Care Medicines Development Group, Groton, CT 06340, USA
    Semin Arthritis Rheum 43:1-8. 2013
  3. doi request reprint A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
    Marie Pierre Hellio Le Graverand
    Medicines Development Group, Primary Care Business Unit, Pfizer Inc, 445 Eastern Point Road, Groton, CT 06340, USA
    Ann Rheum Dis 72:187-95. 2013
  4. pmc Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, A5020 Salzburg, Austria
    Arthritis Res Ther 11:R90. 2009
  5. doi request reprint Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees
    M P Hellio le Graverand
    Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Ann Rheum Dis 67:1562-6. 2008
  6. doi request reprint Radiographic-based grading methods and radiographic measurement of joint space width in osteoarthritis
    Marie Pierre Hellio Le Graverand
    Clinical Development and Medical Affairs, Inflammation, Specialty Care Business Unit, Pfizer Inc, 50 Pequot Avenue, New London, CT 06320, USA
    Radiol Clin North Am 47:567-79. 2009
  7. doi request reprint Radiographic grading and measurement of joint space width in osteoarthritis
    Marie Pierre Hellio Le Graverand
    Clinical Development and Medical Affairs, Inflammation, Specialty Care Business Unit, Pfizer Inc, 50 Pequot Avenue, New London, CT 06320, USA
    Rheum Dis Clin North Am 35:485-502. 2009
  8. ncbi request reprint Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets
    Marie Pierre Hellio Le Graverand-Gastineau
    Pfizer Global Research and Development, New London, CT, USA
    Curr Drug Targets 11:528-35. 2010
  9. pmc Superiority of the Lyon schuss view over the standing anteroposterior view for detecting joint space narrowing, especially in the lateral tibiofemoral compartment, in early knee osteoarthritis
    F Merle-Vincent
    Claude Bernard University, Pavillon 2B, Centre Hospitalier Lyon Sud, 69495 Pierre Benite Cedex, France
    Ann Rheum Dis 66:747-53. 2007
  10. ncbi request reprint Influence of the quality of tibial plateau alignment on the reproducibility of computer joint space measurement from Lyon schuss radiographic views of the knee in patients with knee osteoarthritis
    T Conrozier
    Service de Rhumatologie, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Osteoarthritis Cartilage 12:765-70. 2004

Collaborators

Detail Information

Publications11

  1. doi request reprint OA clinical trials: current targets and trials for OA. Choosing molecular targets: what have we learned and where we are headed?
    M P Hellio Le Graverand-Gastineau
    Pfizer Global Research and Development, 50 Pequot Avenue, New London, 06320 CT, USA
    Osteoarthritis Cartilage 17:1393-401. 2009
    ..The purpose of this article is to review the current status of drug development as it relates to both molecular targets and clinical trials for osteoarthritis (OA)...
  2. doi request reprint Considerations when designing a disease-modifying osteoarthritis drug (DMOAD) trial using radiography
    Marie Pierre Hellio Le Graverand
    Pfizer Inc, Primary Care Medicines Development Group, Groton, CT 06340, USA
    Semin Arthritis Rheum 43:1-8. 2013
    ..Using placebo data from a recently completed disease-modifying osteoarthritis (OA) drug trial, we seek to inform study design of future radiographic studies...
  3. doi request reprint A 2-year randomised, double-blind, placebo-controlled, multicentre study of oral selective iNOS inhibitor, cindunistat (SD-6010), in patients with symptomatic osteoarthritis of the knee
    Marie Pierre Hellio Le Graverand
    Medicines Development Group, Primary Care Business Unit, Pfizer Inc, 445 Eastern Point Road, Groton, CT 06340, USA
    Ann Rheum Dis 72:187-95. 2013
    ..Randomisation was stratified by KLG. Radiographs to assess joint space narrowing (JSN) were acquired using the modified Lyon-schuss protocol at baseline, week 48 and 96...
  4. pmc Relationship of compartment-specific structural knee status at baseline with change in cartilage morphology: a prospective observational study using data from the osteoarthritis initiative
    Felix Eckstein
    Institute of Anatomy and Musculoskeletal Research, Paracelsus Medical University, A5020 Salzburg, Austria
    Arthritis Res Ther 11:R90. 2009
    ....
  5. doi request reprint Head-to-head comparison of the Lyon Schuss and fixed flexion radiographic techniques. Long-term reproducibility in normal knees and sensitivity to change in osteoarthritic knees
    M P Hellio le Graverand
    Pfizer Global Research and Development, Ann Arbor, MI 48105, USA
    Ann Rheum Dis 67:1562-6. 2008
    ..Both position the knee identically but only the LS aligns the medial tibial plateau (MTP) with the x-ray beam fluoroscopically. The present study provides the first head-to-head comparison of the LS and FF views...
  6. doi request reprint Radiographic-based grading methods and radiographic measurement of joint space width in osteoarthritis
    Marie Pierre Hellio Le Graverand
    Clinical Development and Medical Affairs, Inflammation, Specialty Care Business Unit, Pfizer Inc, 50 Pequot Avenue, New London, CT 06320, USA
    Radiol Clin North Am 47:567-79. 2009
    ..Semiautomated software has been developed to improve the accuracy of JSW measurement over manual methods. JSW measurements include minimum JSW, mean JSW or joint space area and JSW at fixed locations...
  7. doi request reprint Radiographic grading and measurement of joint space width in osteoarthritis
    Marie Pierre Hellio Le Graverand
    Clinical Development and Medical Affairs, Inflammation, Specialty Care Business Unit, Pfizer Inc, 50 Pequot Avenue, New London, CT 06320, USA
    Rheum Dis Clin North Am 35:485-502. 2009
    ..Semiautomated software has been developed to improve the accuracy of JSW measurement over manual methods. JSW measurements include minimum JSW, mean JSW or joint space area, and JSW at fixed locations...
  8. ncbi request reprint Disease modifying osteoarthritis drugs: facing development challenges and choosing molecular targets
    Marie Pierre Hellio Le Graverand-Gastineau
    Pfizer Global Research and Development, New London, CT, USA
    Curr Drug Targets 11:528-35. 2010
    ..Current research pursues a variety of molecular targets including anti-catabolic agents to slow or halt OA progression and anabolic drugs to induce cartilage re-growth...
  9. pmc Superiority of the Lyon schuss view over the standing anteroposterior view for detecting joint space narrowing, especially in the lateral tibiofemoral compartment, in early knee osteoarthritis
    F Merle-Vincent
    Claude Bernard University, Pavillon 2B, Centre Hospitalier Lyon Sud, 69495 Pierre Benite Cedex, France
    Ann Rheum Dis 66:747-53. 2007
    ..To evaluate the validity of using the conventional anteroposterior (AP) radiograph of the knee in order to identify joint space narrowing (JSN) at an early stage of osteoarthritis (OA)...
  10. ncbi request reprint Influence of the quality of tibial plateau alignment on the reproducibility of computer joint space measurement from Lyon schuss radiographic views of the knee in patients with knee osteoarthritis
    T Conrozier
    Service de Rhumatologie, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Osteoarthritis Cartilage 12:765-70. 2004
    ..The quality of medial tibial plateau (MT-Plateau) alignment is one of the key elements for accuracy and sensitivity to change of knee radiography in knee osteoarthritis (OA)...
  11. ncbi request reprint Epidemiological, clinical, biological and radiological differences between atrophic and hypertrophic patterns of hip osteoarthritis: a case-control study
    Th Conrozier
    Department of Rheumatology, Centre Hospitalier Lyon Sud, Pierre Benite, France
    Clin Exp Rheumatol 22:403-8. 2004
    ..The aim of this study was to determine the epidemiological, radiological and biological differences between the hypertrophic and atrophic forms of hip osteoarthritis...