Research Topics
Genomes and Genes | Sybil M EngSummaryAffiliation: Pfizer Global Research and Development Country: USA Publications
| Collaborators
|
Detail Information
Publications
Body size changes in relation to postmenopausal breast cancer among women on Long Island, New YorkSybil M Eng
Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY 10017, USA
Am J Epidemiol 162:229-37. 2005..55, 95% CI: 0.32, 0.96). These results add to the literature by focusing on the perimenopausal weight trajectory and support efforts urging women to avoid weight gain as they age...- Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer riskKatherine D Crew
Department of Medicine and the Herbert Irving Comprehensive Cancer Center, Columbia University, 161 Fort Washington Avenue, 10 1072, New York, NY 10032, USA
Carcinogenesis 28:2548-51. 2007..Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in the FAS gene and detectable PAH-DNA adducts... - IGHMBP2 Thr671Ala polymorphism might be a modifier for the effects of cigarette smoking and PAH-DNA adducts to breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
Breast Cancer Res Treat 99:1-7. 2006..Additional studies focused on the biological function of the variant-G allele and interactions with other genetic polymorphisms are necessary to confirm our findings... - MGMT genotype modulates the associations between cigarette smoking, dietary antioxidants and breast cancer riskJing Shen
Department of Environmental Health Sciences, Columbia University, New York, NY 10032, USA
Carcinogenesis 26:2131-7. 2005.... - Polymorphisms in nucleotide excision repair genes, polycyclic aromatic hydrocarbon-DNA adducts, and breast cancer riskKatherine D Crew
Department of Epidemiology, Mailman School of Public Health, Columbia University, 161 Fort Washington Avenue, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 16:2033-41. 2007..Overall, this study suggests that the risk of breast cancer may be elevated among women with polymorphisms in NER pathway genes and detectable PAH-DNA adducts... - Polycyclic aromatic hydrocarbon-DNA adducts and breast cancer: a pooled analysisMarilie D Gammon
Department of Epidemiology, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Arch Environ Health 59:640-9. 2004..These data provide only modest support for an association between PAH-DNA adducts and breast cancer development... 
Estrogen-biosynthesis gene CYP17 and its interactions with reproductive, hormonal and lifestyle factors in breast cancer risk: results from the Long Island Breast Cancer Study ProjectYu Chen
Department of Environmental Medicine and New York University Cancer Institute, New York University School of Medicine, New York, NY 10016, USA
Carcinogenesis 29:766-71. 2008..In conclusion, the findings suggest that the CYP17 variant C allele may increase breast cancer risk in conjunction with long-term HRT use and high BMI in postmenopausal women...- Genetic variation of TP53, polycyclic aromatic hydrocarbon-related exposures, and breast cancer risk among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Breast Cancer Res Treat 108:93-9. 2008..p53 participates in cell cycle control, programmed cell death/apoptosis, and DNA repair, all pathways involved in carcinogenesis. TP53 variants may influence p53 function... 
Polycyclic aromatic hydrocarbon-DNA adducts and survival among women with breast cancerSharon K Sagiv
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Environ Res 109:287-91. 2009..Results from this large population-based study do not provide strong support for an association between detectable PAH-DNA adducts and survival among women with breast cancer, except perhaps among those receiving radiation treatment...- Polymorphisms in XRCC1 modify the association between polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, dietary antioxidants, and breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 14:336-42. 2005..Further understanding of the biological function of XRCC1 variants and their interactions with PAH-DNA adducts, antioxidants, and other genes in the pathway are needed... - MnSOD Val-9Ala genotype, pro- and anti-oxidant environmental modifiers, and breast cancer among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435, Chapel Hill, NC 27599 7435, USA
Cancer Causes Control 16:1225-34. 2005..This study provides little evidence that variation in Val-9Ala polymorphism of MnSOD alone or through substantial interaction with key exposures believed to be pro- or anti-oxidant properties influences breast cancer risk... - OGG1 polymorphisms and breast cancer riskPavel Rossner
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, New York, USA
Cancer Epidemiol Biomarkers Prev 15:811-5. 2006..In addition, data on functionality of these polymorphisms are crucial to understand if these modest differences are important... - The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancerMarilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill 27599 7400, USA
Breast Cancer Res Treat 74:235-54. 2002.... - Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New YorkMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hil, NC 27516, USA
Breast Cancer Res Treat 99:235-40. 2006.... - Xeroderma pigmentosum complementation group C genotypes/diplotypes play no independent or interaction role with polycyclic aromatic hydrocarbons-DNA adducts for breast cancer riskJing Shen
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, 630 West 168th Street, P and S 19 418, New York, NY 10032, USA
Eur J Cancer 44:710-7. 2008..69). These data suggest that XPCs have neither independent effects nor interactions with cigarette smoking and PAH-DNA adducts for breast cancer risk. Further studies with multiple genetic polymorphisms in NER pathway are warranted... - Effects of glutathione S-transferase A1 (GSTA1) genotype and potential modifiers on breast cancer riskJiyoung Ahn
Department of Epidemiology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA
Carcinogenesis 27:1876-82. 2006..These data indicate that GSTA1 genotypes related to reduced GSTA1 expression are associated with increased breast cancer primarily among women with lower consumption of cruciferous vegetables and among current smokers... - Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking, and breast cancer riskMary Beth Terry
Department of Epidemiology, Mailman School of Public Health, Columbia University, PH 18 102, 600 West 168th Street, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 13:2053-8. 2004..Overall, this study suggests that those individuals with this polymorphism in the XPD gene may face an increased risk of breast cancer from PAH-DNA adducts and cigarette smoking... - Weight gain prior to diagnosis and survival from breast cancerRebecca J Cleveland
Department of Epidemiology, University of North Carolina, CB 7435 McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 16:1803-11. 2007.... - Fat or fit: the joint effects of physical activity, weight gain, and body size on breast cancer riskLauren E McCullough
Department of Epidemiology, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA
Cancer 118:4860-8. 2012..These include the minimum duration and intensity necessary for risk reduction and the optimal time period for occurrence, as well as subgroup effects, particularly with regard to tumor heterogeneity and body size... - PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer riskKathleen M McCarty
Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Environ Health Perspect 117:552-8. 2009..Few breast cancer studies have investigated the joint effects of multiple GSTs and a PAH biomarker... - Residential environmental exposures and other characteristics associated with detectable PAH-DNA adducts in peripheral mononuclear cells in a population-based sample of adult femalesSumitra Shantakumar
Department of Epidemiology, CB 7435 McGavran Greenberg Hall, University of North Carolina School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
J Expo Anal Environ Epidemiol 15:482-90. 2005..These data suggest that PAH-DNA adducts detected in a population-based sample of adult women with ambient exposure levels reflect some key residential PAH exposure sources assessed in this study, such as cigarette smoking... - Fruits, vegetables, and micronutrients in relation to breast cancer modified by menopause and hormone receptor statusMia M Gaudet
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 13:1485-94. 2004..Our results support an inverse association for fruit and vegetable intake among postmenopausal but not premenopausal breast cancer, which may be more pronounced among women with ER+ tumors... - Environmental tobacco smoke and breast cancer incidenceMarilie D Gammon
Department of Epidemiology, School of Public Health, University of North Carolina, CB 7435 McGavern Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Environ Res 96:176-85. 2004..42 for ER+ PR+, 95% CI, 1.00, 2.00). Our data suggest that if there is an effect for ETS on breast cancer, that effect is restricted to selected subgroups of women, such as those with long-term exposure from a smoking spouse... - Plasma protein carbonyl levels and breast cancer riskPavel Rossner
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY, USA
J Cell Mol Med 11:1138-48. 2007..8, 95% CI = 1.2-2.6) compared to women with levels below the median for both markers of oxidative stress. In summary, our results suggest that increased plasma protein carbonyl levels may be associated with breast cancer risk... - IGF1 CA repeat polymorphisms, lifestyle factors and breast cancer risk in the Long Island Breast Cancer Study ProjectRebecca J Cleveland
Department of Epidemiology, School of Public Health and Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599 7435, USA
Carcinogenesis 27:758-65. 2006..Our results demonstrate a role for alleles with fewer than (CA)19 repeats as a risk factor for breast cancer and also suggest that several traditional breast cancer risk factors modify the association of the IGF1 (CA)19 repeat genotype... - Environmental toxins and breast cancer on Long Island. II. Organochlorine compound levels in bloodMarilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:686-97. 2002..These findings, based on the largest number of samples analyzed to date among primarily white women, do not support the hypothesis that organochlorines increase breast cancer risk among Long Island women... - Active and passive cigarette smoke and breast cancer survivalSharon K Sagiv
Department of Epidemiology, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Ann Epidemiol 17:385-93. 2007..The association between active and passive cigarette smoking before breast cancer diagnosis and survival was investigated among a cohort of invasive breast cancer cases (n = 1273) participating in a population-based case-control study... - Relationship between urinary 15-F2t-isoprostane and 8-oxodeoxyguanosine levels and breast cancer riskPavel Rossner
Department of Environmental Health Sciences, Mailman School of Public Health, Columbia University, New York, NY 10032, USA
Cancer Epidemiol Biomarkers Prev 15:639-44. 2006..In summary, our results suggest that urinary markers of lipid peroxidation and oxidative DNA damage may be associated with breast cancer risk... - Polymorphisms in oxidative stress genes, physical activity, and breast cancer riskLauren E McCullough
Department of Epidemiology, University of North Carolina, CB 7435, McGavran Greenberg Hall, Chapel Hill, NC 27599 7435, USA
Cancer Causes Control 23:1949-58. 2012..Given the paradoxical effects of physical activity, the oxidative stress pathway is of interest. Genetic variation in CAT or antioxidant-related polymorphisms may mediate the physical activity-breast cancer association... - Associations between polycyclic aromatic hydrocarbon-related exposures and p53 mutations in breast tumorsIrina Mordukhovich
Department of Epidemiology, University of North Carolina, Chapel Hill, North Carolina 27599 7435, USA
Environ Health Perspect 118:511-8. 2010..Objectives: We hypothesized that associations of PAH-related exposures with breast cancer would differ according to tumor p53 mutation status, effect, type, and number... - Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adductsMarilie D Gammon
Department of Epidemiology, University of North Carolina, School of Public Health, Chapel Hill, North Carolina 27599 7435, USA
Cancer Epidemiol Biomarkers Prev 11:677-85. 2002..These data indicate that PAH-DNA adduct formation may influence breast cancer development, although the association does not appear to be dose dependent and may have a threshold effect... - Influence of prediagnostic recreational physical activity on survival from breast cancerRebecca J Cleveland
Department of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599 7280, USA
Eur J Cancer Prev 21:46-54. 2012..no RPA, the HR=0.61; 95% CI=0.39-0.94 and HR=1.00; 95% CI=0.65-1.54, respectively). This study provides support that RPA prior to breast cancer diagnosis improves survival... - Cooked meat and risk of breast cancer--lifetime versus recent dietary intakeSusan E Steck
Department of Nutrition, School of Public Health, University of North Carolina, Chapel Hill, NC, USA
Epidemiology 18:373-82. 2007..Polycyclic aromatic hydrocarbons (PAHs) and heterocyclic amines (HCAs) are carcinogens formed in or on the surface of well-done meat, cooked at high temperature...