- Assessing the translatability of in vivo cardiotoxicity mechanisms to in vitro models using causal reasoningAhmed E Enayetallah
Compound Safety Prediction, Pfizer Inc, Groton, CT, USA
BMC Pharmacol Toxicol 14:46. 2013..Further assessment and validation of the generated molecular hypotheses would greatly enhance our ability to design predictive in vitro cardiotoxicity assays. ..
- Modeling the mechanism of action of a DGAT1 inhibitor using a causal reasoning platformAhmed E Enayetallah
Compound Safety Prediction Group, Pfizer Inc, Groton, Connecticut, United States of America
PLoS ONE 6:e27009. 2011....
- Assessing statistical significance in causal graphsLeonid Chindelevitch
Computational Sciences Center of Emphasis, Pfizer Worldwide Research and Development, Cambridge, MA, USA
BMC Bioinformatics 13:35. 2012..In this paper we frame and solve two fundamental computational problems that arise in practice when computing appropriate null distributions for hypothesis testing...