J T Downs

Summary

Affiliation: Pfizer Global Research and Development
Country: USA

Publications

  1. ncbi request reprint Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA
    J T Downs
    Inflammation Biology, Pfizer Central Research, Pfizer Inc, Groton, CT 06340 8002, USA
    J Immunol Methods 247:25-34. 2001
  2. ncbi request reprint Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody
    I G Otterness
    Department of Cancer, Immunology, and Infectious Diseases, Pfizer Central Research Division, Pfizer Inc, Groton, CT 06340, USA
    Matrix Biol 18:331-41. 1999
  3. ncbi request reprint Inhibition of interleukin 1 synthesis by tenidap: a new drug for arthritis
    I G Otterness
    Department of Immunology and Infectious Diseases, Pfizer Inc, Groton, CT 06340
    Cytokine 3:277-83. 1991

Detail Information

Publications3

  1. ncbi request reprint Analysis of collagenase-cleavage of type II collagen using a neoepitope ELISA
    J T Downs
    Inflammation Biology, Pfizer Central Research, Pfizer Inc, Groton, CT 06340 8002, USA
    J Immunol Methods 247:25-34. 2001
    ..This assay can be used for monitoring type II collagen metabolism in patients with osteoarthritis...
  2. ncbi request reprint Detection of collagenase-induced damage of collagen by 9A4, a monoclonal C-terminal neoepitope antibody
    I G Otterness
    Department of Cancer, Immunology, and Infectious Diseases, Pfizer Central Research Division, Pfizer Inc, Groton, CT 06340, USA
    Matrix Biol 18:331-41. 1999
    ..By contrast, in the group with damaged collagen, the cartilage was fibrillated in all animals and in half of those, the cartilage failed and bony eburnation resulted...
  3. ncbi request reprint Inhibition of interleukin 1 synthesis by tenidap: a new drug for arthritis
    I G Otterness
    Department of Immunology and Infectious Diseases, Pfizer Inc, Groton, CT 06340
    Cytokine 3:277-83. 1991
    ..As the appearance of IL-1 was inhibited both intracellularly and extracellularly, the primary drug effect cannot be on secretion...